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IID00912
 UniprotO15054
ProteinLysine-specific demethylase 6B
GeneKDM6B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1643
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1141-1643 Homo dimer :
 Evidence X-RAY 4ask A Reference
       Region 4ask A 1141-1176 disorder
       Region 4ask A 1177-1292 order
       Region 4ask A 1293-1322 disorder
       Region 4ask A 1323-1591 order
       Region 4ask A 1592-1595 disorder
       Region 4ask A 1596-1638 order
       Region 4ask A 1639-1643 disorder
 Evidence X-RAY 4ask B Reference
       Region 4ask B 1141-1179 disorder
       Region 4ask B 1180-1292 order
       Region 4ask B 1293-1322 disorder
       Region 4ask B 1323-1590 order
       Region 4ask B 1591-1596 disorder
       Region 4ask B 1597-1638 order
       Region 4ask B 1639-1643 disorder
Seq 1141-1643 Hetero dimer : IID00062Complex
 Evidence X-RAY 5oy3 A Reference
       Region 5oy3 A 1141-1156 disorder
       Region 5oy3 A 1157-1291 order
       Region 5oy3 A 1292-1323 disorder
       Region 5oy3 A 1324-1591 order
       Region 5oy3 A 1592-1592 disorder
       Region 5oy3 A 1593-1639 order
       Region 5oy3 A 1640-1643 disorder
 Evidence X-RAY 6f6d A Reference
       Region 6f6d A 1141-1156 disorder
       Region 6f6d A 1157-1291 order
       Region 6f6d A 1292-1323 disorder
       Region 6f6d A 1324-1638 order
       Region 6f6d A 1639-1643 disorder
Seq 1141-1643 Monomer :
 Evidence X-RAY 2xue A Reference
       Region 2xue A 1141-1177 disorder
       Region 2xue A 1178-1292 order
       Region 2xue A 1293-1323 disorder
       Region 2xue A 1324-1592 order
       Region 2xue A 1593-1595 disorder
       Region 2xue A 1596-1638 order
       Region 2xue A 1639-1643 disorder
 Evidence X-RAY 2xue B Reference
       Region 2xue B 1141-1180 disorder
       Region 2xue B 1181-1292 order
       Region 2xue B 1293-1322 disorder
       Region 2xue B 1323-1590 order
       Region 2xue B 1591-1595 disorder
       Region 2xue B 1596-1638 order
       Region 2xue B 1639-1643 disorder
 Evidence X-RAY 5fp3 A Reference
       Region 5fp3 A 1141-1176 disorder
       Region 5fp3 A 1177-1292 order
       Region 5fp3 A 1293-1319 disorder
       Region 5fp3 A 1320-1638 order
       Region 5fp3 A 1639-1643 disorder
 Evidence X-RAY 5fp3 B Reference
       Region 5fp3 B 1141-1179 disorder
       Region 5fp3 B 1180-1292 order
       Region 5fp3 B 1293-1322 disorder
       Region 5fp3 B 1323-1590 order
       Region 5fp3 B 1591-1596 disorder
       Region 5fp3 B 1597-1638 order
       Region 5fp3 B 1639-1643 disorder
Seq 1176-1505 Monomer :
 Evidence X-RAY 2xxz A Reference
       Region 2xxz A 1176-1177 disorder
       Region 2xxz A 1178-1295 order
       Region 2xxz A 1296-1322 disorder
       Region 2xxz A 1323-1496 order
       Region 2xxz A 1497-1505 disorder
 Evidence X-RAY 2xxz B Reference
       Region 2xxz B 1176-1177 disorder
       Region 2xxz B 1178-1293 order
       Region 2xxz B 1294-1322 disorder
       Region 2xxz B 1323-1359 order
       Region 2xxz B 1360-1369 disorder
       Region 2xxz B 1370-1502 order
       Region 2xxz B 1503-1505 disorder
Seqphosphorylation
    224-224 Phosphoserine
 
Prediction
NeProc
Disorder 1-1129,1294-1322,1639-1643
Order 1130-1166,1173-1293,1323-1638
ProS 1-63,68-133,146-159,814-820,830-835,914-918,1015-1040,1103-1109,1116-1121,1294-1300
AlphaFold
Disorder 1-87,156-168,185-253,255-697,712-908,910-910,921-921,923-1127,1152-1152,1302-1322,1592-1595,1640-1643
Order 88-155,169-184,254-254,698-711,909-909,911-920,922-922,1128-1151,1153-1301,1323-1591,1596-1639
SEG 54-74 ,200-227 ,239-268 ,310-327 ,331-344 ,387-412 ,457-483 ,511-520 ,540-575 ,583-611 ,635-655 ,740-764 ,769-809 ,838-877 ,888-906 ,973-988 ,1041-1068 ,1286-1320
Function
Function in SwissProt
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).