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IID00915
 UniprotO60711
ProteinLeupaxin
GeneLPXN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
386
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-20 Hetero trimer : Q14289
 Evidence X-RAY 4xef B Reference
       Region 4xef B 1-15 order
       Region 4xef B 16-20 disorder
 Evidence X-RAY 4xef C Reference
       Region 4xef C 1-13 order
       Region 4xef C 14-20 disorder
 Evidence X-RAY 4xef E Reference
       Region 4xef E 1-15 order
       Region 4xef E 16-20 disorder
 Evidence X-RAY 4xef F Reference
       Region 4xef F 1-1 disorder
       Region 4xef F 2-13 order
       Region 4xef F 14-20 disorder
Seq 86-104 Hetero dimer : Q14289
 Evidence X-RAY 4xek C Reference
       Region 4xek C 86-101 order
       Region 4xek C 102-104 disorder
 Evidence X-RAY 4xev C Reference
       Region 4xev C 86-104 order
 Evidence X-RAY 4xev F Reference
       Region 4xev F 86-103 order
       Region 4xev F 104-104 disorder
Seq 260-326 Monomer :
 Evidence NMR 1x3h A Reference
       Region 1x3h A 260-326 order
       Region 1x3h A 260-264 high_rmsd
Seqphosphorylation
    19-19 Phosphoserine
    22-22 Phosphotyrosine
    54-54 Phosphoserine
    62-62 Phosphotyrosine
    72-72 Phosphotyrosine; by LYN
    81-81 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-143
Order 144-386
ProS 1-21,100-110,133-143
AlphaFold
Disorder 1-1,14-87,89-89,106-127,135-135,139-139,141-148
Order 2-13,88-88,90-105,128-134,136-138,140-140,149-386
Pfam Hmmer
211->267 152-208 270->326
SEG 2-12 ,73-92 ,132-143
Function
Function in SwissProt
Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.