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IID00916
 UniprotO60829
ProteinP antigen family member 4
GenePAGE4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
102
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-102
 Evidence NMR¸ CD The CD and NMR data show that PAGE4 does not have detectable secondary and tertiary structure, consistent with an IDP. Reference
       Region 1-102 disorder
Seq 1-102 Hetero tetramer : O95271
 Evidence X-RAY 6urq C Reference
       Region 6urq C 1-9 disorder
       Region 6urq C 10-17 order
       Region 6urq C 18-102 disorder
 Evidence X-RAY 6urq D Reference
       Region 6urq D 1-9 disorder
       Region 6urq D 10-17 order
       Region 6urq D 18-102 disorder
SeqProS verified 10-17 Hetero tetramer : O95271
       Region 6urq C 10-17 order
       Region 6urq D 10-17 order
       Region 1-102 disorder
Seqphosphorylation
    85-85 Phosphothreonine; by CLK2
    94-94 Phosphothreonine; by CLK2
    79-79 Phosphoserine; by CLK2
    73-73 Phosphoserine; by CLK2
    71-71 Phosphothreonine; by CLK2
    51-51 Phosphothreonine; by HIPK1 and CLK2
    7-7 Phosphoserine; by CLK2
    9-9 Phosphoserine; by HIPK1 and CLK2
 
Prediction
NeProc
Disorder 1-102
ProS 1-16,37-47,52-102
AlphaFold
Disorder 1-3,5-6,8-8,10-10,12-34,36-42,44-51,53-65,71-71,76-76,78-78,81-81,91-94,96-102
Order 4-4,7-7,9-9,11-11,35-35,43-43,52-52,66-70,72-75,77-77,79-80,82-90,95-95
SEG 2-15
Function
Function in SwissProt
Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway (PubMed:21357425, PubMed:25374899, PubMed:30658679).