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IID00919
UniprotO75381
ProteinPeroxisomal membrane protein PEX14
GenePEX14
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
377
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 16-80 Hetero dimer : IID00944Complex
 Evidence NMR 4bxu A Reference
       Region 4bxu A 16-80 order
       Region 4bxu A 16-22 high_rmsd
       Region 4bxu A 73-80 high_rmsd
Seq 16-80 Hetero dimer : IID00944Complex
 Evidence NMR 2w84 A Reference
       Region 2w84 A 16-19 disorder
       Region 2w84 A 20-76 order
       Region 2w84 A 20-21 high_rmsd
       Region 2w84 A 76-76 high_rmsd
       Region 2w84 A 77-80 disorder
Seq 16-80 Hetero dimer : IID00937Complex
 Evidence NMR 2w85 A Reference
       Region 2w85 A 16-19 disorder
       Region 2w85 A 20-76 order
       Region 2w85 A 77-80 disorder
Seqphosphorylation
    232-232 Phosphoserine
    282-282 Phosphoserine
    335-335 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    34-34 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-24,71-95,149-162,198-305,341-377
Order 25-70,101-148,163-197,306-340
ProS 149-162,198-226,239-242,302-305,341-377
AlphaFold
Disorder 1-25,73-104,137-139,225-240,242-377
Order 26-72,105-136,140-224,241-241
SEG 2-15 ,158-187 ,244-262 ,265-275 ,316-341
Function
Function in SwissProt
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:24235149, PubMed:28765278). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035).