IDEAL List

IDEAL

IID00921
UniprotO95166
ProteinGamma-aminobutyric acid receptor-associated protein
GeneGABARAP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

117

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 1-112 Hetero dimer : IID00669Complex

Evidence X-RAY 6hok A Reference

Region 6hok A 1-112 order

Seq 1-112 Hetero hexamer : IID00669Complex

Evidence X-RAY 6hoj A Reference

Region 6hoj A 1-112 order

Evidence X-RAY 6hoj B Reference

Region 6hoj B 1-112 order

Evidence X-RAY 6hoj C Reference

Region 6hoj C 1-112 order

Seq 1-116 Hetero hexamer : IID00922Complex

Evidence X-RAY 7bru A Reference

Region 7bru A 1-116 order

Evidence X-RAY 7bru B Reference

Region 7bru B 1-116 order

Evidence X-RAY 7bru C Reference

Region 7bru C 1-116 order

Seq 1-116 Hetero 23mer : IID01040Complex

Evidence X-RAY 7vec A Reference

Region 7vec A 1-116 order

Evidence X-RAY 7vec B Reference

Region 7vec B 1-116 order

Evidence X-RAY 7vec C Reference

Region 7vec C 1-116 order

Evidence X-RAY 7vec D Reference

Region 7vec D 1-116 order

Evidence X-RAY 7vec E Reference

Region 7vec E 1-116 order

Evidence X-RAY 7vec F Reference

Region 7vec F 1-115 order

Region 7vec F 116-116 disorder

Evidence X-RAY 7vec G Reference

Region 7vec G 1-116 order

Evidence X-RAY 7vec H Reference

Region 7vec H 1-116 order

Evidence X-RAY 7vec I Reference

Region 7vec I 1-116 order

Evidence X-RAY 7vec J Reference

Region 7vec J 1-116 order

Evidence X-RAY 7vec K Reference

Region 7vec K 1-116 order

Evidence X-RAY 7vec L Reference

Region 7vec L 1-116 order

Seq 1-116 Hetero dimer : IID00993Complex

Evidence X-RAY 7yo9 A Reference

Region 7yo9 A 1-116 order

Seq 1-116 Hetero tetramer : IID01010Complex

Evidence X-RAY 7brt A Reference

Region 7brt A 1-116 order

Evidence X-RAY 7brt B Reference

Region 7brt B 1-116 order

Seq 1-116 Hetero dimer : IID01020Complex

Evidence X-RAY 7brq A Reference

Region 7brq A 1-116 order

Seq 1-116 Hetero tetramer : IID01040Complex

Evidence X-RAY 7ved A Reference

Region 7ved A 1-116 order

Evidence X-RAY 7ved B Reference

Region 7ved B 1-116 order

Seq 1-117 Hetero tetramer : IID00980Complex

Evidence X-RAY 6hyl A Reference

Region 6hyl A 1-117 order

Evidence X-RAY 6hyl B Reference

Region 6hyl B 1-117 order

Seq 1-117 Hetero trimer : IID01021Complex

Evidence X-RAY 7ea7 A Reference

Region 7ea7 A 1-116 order

Region 7ea7 A 117-117 disorder

Evidence X-RAY 7ea7 B Reference

Region 7ea7 B 1-114 order

Region 7ea7 B 115-117 disorder

Seq 1-117 Hetero octamer : IID00952Complex

Evidence X-RAY 7bv4 A Reference

Region 7bv4 A 1-112 order

Region 7bv4 A 113-117 disorder

Evidence X-RAY 7bv4 B Reference

Region 7bv4 B 1-112 order

Region 7bv4 B 113-117 disorder

Evidence X-RAY 7bv4 E Reference

Region 7bv4 E 1-117 order

Evidence X-RAY 7bv4 G Reference

Region 7bv4 G 1-117 order

Seq 1-117 Hetero dimer :

Evidence X-RAY 3d32 A Reference

Region 3d32 A 1-116 order

Region 3d32 A 117-117 disorder

Seq 1-117 Monomer :

Evidence X-RAY 1gnu A Reference

Region 1gnu A 1-117 order

Evidence NMR 1klv A Reference

Region 1klv A 1-17 disorder

Region 1klv A 18-117 order

Region 1klv A 113-117 high_rmsd

Evidence NMR 1km7 A Reference

Region 1km7 A 1-17 disorder

Region 1km7 A 18-117 order

Evidence NMR 1kot A Reference

Region 1kot A 1-117 order

Evidence X-RAY 6hb9 A Reference

Region 6hb9 A 3-116 order

Evidence X-RAY 7aa8 C Reference

Region 7aa8 C 1-112 order

Region 7aa8 C 113-117 disorder

Evidence X-RAY 7zkr A Reference

Region 7zkr A 1-115 order

Region 7zkr A 116-117 disorder

Seq 1-117 Hetero dimer :

Evidence X-RAY 3d32 B Reference

Region 3d32 B 1-116 order

Region 3d32 B 117-117 disorder

Seq 1-117 Hetero dimer : IID00994Complex

Evidence X-RAY 3wim A Reference

Region 3wim A 1-117 order

Seq 1-117 Hetero dimer : IID00917Complex

Evidence X-RAY 6hyn A Reference

Region 6hyn A 1-117 order

Seq 1-117 Hetero dodecamer : IID01026Complex

Evidence X-RAY 7lsw A Reference

Region 7lsw A 1-117 order

Evidence X-RAY 7lsw B Reference

Region 7lsw B 1-117 order

Evidence X-RAY 7lsw C Reference

Region 7lsw C 1-117 order

Evidence X-RAY 7lsw D Reference

Region 7lsw D 1-117 order

Evidence X-RAY 7lsw E Reference

Region 7lsw E 1-115 order

Region 7lsw E 116-117 disorder

Evidence X-RAY 7lsw F Reference

Region 7lsw F 1-115 order

Region 7lsw F 116-117 disorder

Seq 1-117 Hetero dimer : P27797

Evidence X-RAY 3dow A Reference

Region 3dow A 1-117 order

Seq 1-117 Hetero dimer : IID00920Complex

Evidence X-RAY 6hyo A Reference

Region 6hyo A 1-117 order

Seq 1-117 Hetero hexamer : IID01026Complex

Evidence X-RAY 7lt6 A Reference

Region 7lt6 A 1-117 order

Evidence X-RAY 7lt6 B Reference

Region 7lt6 B 1-117 order

Evidence X-RAY 7lt6 C Reference

Region 7lt6 C 1-117 order

Seq 1-117 Hetero dimer : IID01036Complex

Evidence X-RAY 6yop A Reference

Region 6yop A 1-117 order

Seq 1-117 Homo dimer :

Evidence X-RAY 7zl7 A Reference

Region 7zl7 A 1-117 order

Evidence X-RAY 7zl7 C Reference

Region 7zl7 C 1-117 order

Seq 1-117 Hetero tetramer : IID00980Complex

Evidence X-RAY 6hym A Reference

Region 6hym A 1-117 order

Evidence X-RAY 6hym B Reference

Region 6hym B 1-117 order

Seq 2-112 Hetero octamer : IID00996Complex

Evidence X-RAY 6hoh A Reference

Region 6hoh A 2-112 order

Evidence X-RAY 6hoh B Reference

Region 6hoh B 2-112 order

Evidence X-RAY 6hoh C Reference

Region 6hoh C 2-112 order

Evidence X-RAY 6hoh D Reference

Region 6hoh D 2-112 order

Seq 2-112 Hetero dimer : IID00996Complex

Evidence X-RAY 6hog A Reference

Region 6hog A 2-112 order

Seq 2-116 Hetero hexadecamer : IID01023Complex

Evidence X-RAY 8afi A Reference

Region 8afi A 2-116 order

Evidence X-RAY 8afi C Reference

Region 8afi C 2-2 disorder

Region 8afi C 3-116 order

Evidence X-RAY 8afi E Reference

Region 8afi E 2-116 order

Evidence X-RAY 8afi G Reference

Region 8afi G 2-2 disorder

Region 8afi G 3-116 order

Evidence X-RAY 8afi I Reference

Region 8afi I 2-116 order

Evidence X-RAY 8afi K Reference

Region 8afi K 2-116 order

Evidence X-RAY 8afi M Reference

Region 8afi M 2-2 disorder

Region 8afi M 3-115 order

Region 8afi M 116-116 disorder

Evidence X-RAY 8afi O Reference

Region 8afi O 2-116 order

Seq 2-117 Hetero dimer : IID01034Complex

Evidence X-RAY 5dps B Reference

Region 5dps B 2-114 order

Region 5dps B 115-117 disorder

Seq 2-117 Hetero dimer : IID01034Complex

Evidence X-RAY 5dps A Reference

Region 5dps A 2-115 order

Region 5dps A 116-117 disorder

Seq 2-117 Hetero dimer : IID01034Complex

Evidence X-RAY 5dps C Reference

Region 5dps C 2-114 order

Region 5dps C 115-117 disorder

Seq 3-116 Hetero dimer : IID00990Complex

Evidence X-RAY 4xc2 A Reference

Region 4xc2 A 3-116 order

Evidence X-RAY 4xc2 B Reference

Region 4xc2 B 3-116 order

Evidence X-RAY 4xc2 C Reference

Region 4xc2 C 3-116 order

Evidence X-RAY 4xc2 D Reference

Region 4xc2 D 3-116 order

Prediction

NeProc

Order 1-86,92-117

AlphaFold

Disorder 115-117

Order 1-114

Function

Function in SwissProt

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:9892355). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15169837, PubMed:20562859, PubMed:22948227). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (PubMed:25684205). Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (PubMed:25684205). Involved in apoptosis (PubMed:15977068).

Biological Process

See also
Diagram with PDB data
KBTBD6/GABARAP	Crystal structure of GABARAP in complex with KBTBD6 LIR peptide
TX264/GABARAP	Crystal structure of GABARAP complexed with the TEX264 LIR phosphorylated at Ser271 and Ser272