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IID00922
 UniprotO95197
ProteinReticulon-3
GeneRTN3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1032
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 244-264 Hetero hexamer : IID00921Complex
 Evidence X-RAY 7bru A Reference
       Region 7bru A 244-264 order
 Evidence X-RAY 7bru B Reference
       Region 7bru B 244-245 disorder
       Region 7bru B 246-264 order
 Evidence X-RAY 7bru C Reference
       Region 7bru C 244-264 order
Seqphosphorylation
    30-30 Phosphoserine
    229-229 Phosphoserine
    243-243 Phosphoserine
    246-246 Phosphoserine
    283-283 Phosphoserine
    316-316 Phosphoserine
    453-453 Phosphoserine
    649-649 Phosphoserine
    650-650 Phosphoserine
    735-735 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-246,269-317,325-330,347-832,860-864,1025-1032
Order 247-268,318-324,331-346,833-859,865-1024
ProS 10-14,38-53,58-63,89-102,107-126,137-143,150-209,218-226,236-242,269-317,325-330,347-350,356-407,413-438,455-461,474-484,501-523,534-545,708-713,737-751,860-864,1025-1028
AlphaFold
Disorder 1-254,262-318,340-736,756-829,831-843,906-909,919-922,1024-1032
Order 255-261,319-339,737-755,830-830,844-905,910-918,923-1023
SEG 5-38 ,41-66
Function
Function in SwissProt
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.
(Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses.