Search Keyword:


Search option:


IID00923
 UniprotO95239
ProteinChromosome-associated kinesin KIF4A
GeneKIF4A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1232
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1192-1232 Hetero dimer : IID00975Complex
 Evidence X-RAY 6oyl B Reference
       Region 6oyl B 1192-1220 disorder
       Region 6oyl B 1221-1232 order
SeqProS predicted 1221-1232 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00975Complex
       Region 6oyl B 1221-1232 order
Seqphosphorylation
    995-995 Phosphothreonine
    394-394 Phosphoserine
    1001-1001 Phosphoserine
    1013-1013 Phosphoserine
    1017-1017 Phosphoserine
    1028-1028 Phosphoserine
    951-951 Phosphoserine
    815-815 Phosphoserine
    810-810 Phosphoserine
    801-801 Phosphoserine
    799-799 Phosphothreonine
    1225-1225 Phosphoserine
    1126-1126 Phosphoserine
    1186-1186 Phosphoserine
    1181-1181 Phosphothreonine
 
Prediction
NeProc
Disorder 1-6,372-382,458-518,547-553,679-685,735-740,785-812,926-930,938-952,1001-1089,1113-1232
Order 7-371,383-457,519-546,554-678,686-734,741-784,813-925,931-937,953-1000,1090-1112
ProS 458-480,512-518,547-553,679-685,796-812,926-930,1001-1001,1018-1030,1067-1089,1113-1121,1143-1175,1212-1229
AlphaFold
Disorder 1-6,156-159,168-169,199-208,228-229,247-252,280-283,368-385,438-439,442-447,474-511,585-592,594-594,725-737,788-813,846-848,940-956,998-1084,1122-1232
Order 7-155,160-167,170-198,209-227,230-246,253-279,284-367,386-437,440-441,448-473,512-584,593-593,595-724,738-787,814-845,849-939,957-997,1085-1121
SEG 356-367 ,524-542 ,571-583 ,932-942 ,1056-1069
Function
Function in SwissProt
Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).