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IID00926
 UniprotP16035
ProteinMetalloproteinase inhibitor 2
GeneTIMP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
220
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 27-153 Monomer :
 Evidence NMR 2tmp A Reference
       Region 2tmp A 27-153 order
Seq 27-220 Hetero dimer : P09238
 Evidence X-RAY 4ilw A Reference
       Region 4ilw A 27-208 order
       Region 4ilw A 209-220 disorder
 Evidence X-RAY 4ilw B Reference
       Region 4ilw B 27-208 order
       Region 4ilw B 209-220 disorder
Seq 27-220 Hetero dimer : IID00296Complex
 Evidence X-RAY 1gxd C Reference
       Region 1gxd C 27-218 order
       Region 1gxd C 219-220 disorder
 Evidence X-RAY 1gxd D Reference
       Region 1gxd D 27-218 order
       Region 1gxd D 219-220 disorder
Seq 27-220 Monomer :
 Evidence X-RAY 1br9 A Reference
       Region 1br9 A 27-208 order
       Region 1br9 A 209-220 disorder
SeqProS verified 209-218 Hetero dimer : IID00296Complex
       Region 1gxd C 27-218 order
       Region 1gxd D 27-218 order
       Region 1br9 A 209-220 disorder
 
Prediction
NeProc
Disorder 1-25,217-220
Order 26-216
ProS 9-25,217-220
AlphaFold
Disorder 1-2,20-25,218-220
Order 3-19,26-217
SEG 2-21
Function
Function in SwissProt
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.