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IID00927
 UniprotP16298
ProteinSerine/threonine-protein phosphatase 2B catalytic subunit beta isoform
GenePPP3CB
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
524
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-524 Hetero dimer : IID00060Complex
 Evidence X-RAY 4or9 A Reference
       Region 4or9 A 1-14 disorder
       Region 4or9 A 15-387 order
       Region 4or9 A 388-415 disorder
       Region 4or9 A 416-423 order
       Region 4or9 A 424-477 disorder
       Region 4or9 A 478-495 order
       Region 4or9 A 496-524 disorder
 Evidence X-RAY 4ora A Reference
       Region 4ora A 1-14 disorder
       Region 4ora A 15-386 order
       Region 4ora A 387-415 disorder
       Region 4ora A 416-422 order
       Region 4ora A 423-477 disorder
       Region 4ora A 478-495 order
       Region 4ora A 496-524 disorder
 Evidence X-RAY 4orc A Reference
       Region 4orc A 1-12 disorder
       Region 4orc A 13-386 order
       Region 4orc A 387-417 disorder
       Region 4orc A 418-421 order
       Region 4orc A 422-524 disorder
SeqProS possible 416-423 Same region of the homolog (Q08209, IID00069, 84% identity) is disordered in the free state. Hetero dimer : IID00060Complex
       Region 4or9 A 416-423 order
       Region 4ora A 416-422 order
Seqphosphorylation
    478-478 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-17,385-463,466-477,492-524
Order 18-384,464-465,478-491
ProS 398-451,455-456,466-477,492-497,517-520
AlphaFold
Disorder 1-9,19-21,381-398,428-450,453-457,459-475,496-524
Order 10-18,22-380,399-427,451-452,458-458,476-495
SEG 2-21
Function
Function in SwissProt
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:32753672, PubMed:26794871). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity).