Search Keyword:


Search option:


IID00928
 UniprotP18206
ProteinVinculin
GeneVCL
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1134
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-252 Hetero dimer : IID50205Complex
 Evidence X-RAY 3s90 A Reference
       Region 3s90 A 1-2 disorder
       Region 3s90 A 3-250 order
       Region 3s90 A 251-252 disorder
 Evidence X-RAY 3s90 B Reference
       Region 3s90 B 1-1 disorder
       Region 3s90 B 2-252 order
Seq 1-252 Hetero dimer : IID00797Complex
 Evidence X-RAY 4ehp A Reference
       Region 4ehp A 1-1 disorder
       Region 4ehp A 2-219 order
       Region 4ehp A 220-222 disorder
       Region 4ehp A 223-252 order
Seq 1-255 Hetero dimer : B0BXR4
 Evidence X-RAY 3tj5 A Reference
       Region 3tj5 A 1-1 disorder
       Region 3tj5 A 2-255 order
Seq 1-257 Hetero dimer : B0BXR4
 Evidence X-RAY 3tj6 A Reference
       Region 3tj6 A 1-29 order
       Region 3tj6 A 30-33 disorder
       Region 3tj6 A 34-257 order
Seq 1-258 Hetero dimer : IID00129Complex
 Evidence X-RAY 1ydi A Reference
       Region 1ydi A 1-28 order
       Region 1ydi A 29-35 disorder
       Region 1ydi A 36-258 order
Seq 1-258 Hetero dimer : Q9Y490
 Evidence X-RAY 1syq A Reference
       Region 1syq A 1-258 order
Seq 1-258 Hetero dimer : Q9Y490
 Evidence X-RAY 4dj9 A Reference
       Region 4dj9 A 1-2 disorder
       Region 4dj9 A 3-30 order
       Region 4dj9 A 31-34 disorder
       Region 4dj9 A 35-215 order
       Region 4dj9 A 216-220 disorder
       Region 4dj9 A 221-254 order
       Region 4dj9 A 255-258 disorder
Seq 1-258 Hetero dimer : P18010
 Evidence X-RAY 2gww A Reference
       Region 2gww A 1-258 order
Seq 1-258 Hetero trimer : P18010
 Evidence X-RAY 2ibf A Reference
       Region 2ibf A 1-258 order
Seq 1-258 Hetero dimer : P18010
 Evidence X-RAY 2hsq A Reference
       Region 2hsq A 1-29 order
       Region 2hsq A 30-34 disorder
       Region 2hsq A 35-258 order
Seq 1-258 Hetero dimer : P18010
 Evidence X-RAY 3rf3 A Reference
       Region 3rf3 A 1-1 disorder
       Region 3rf3 A 2-258 order
 Evidence X-RAY 3rf3 B Reference
       Region 3rf3 B 1-258 order
Seq 1-258 Hetero dimer : IID50213Complex
 Evidence X-RAY 1rkc A Reference
       Region 1rkc A 1-258 order
Seq 1-915,984-1134 Monomer :
 Evidence X-RAY 1tr2 A Reference
       Region 1tr2 A 1-843 order
       Region 1tr2 A 844-876 disorder
       Region 1tr2 A 877-915 order
       Region 1tr2 A 984-1129 order
       Region 1tr2 A 1130-1134 disorder
 Evidence X-RAY 1tr2 B Reference
       Region 1tr2 B 1-843 order
       Region 1tr2 B 844-876 disorder
       Region 1tr2 B 877-915 order
       Region 1tr2 B 984-1130 order
       Region 1tr2 B 1131-1134 disorder
 Evidence X-RAY 6fuy A Reference
       Region 6fuy A 1-397 order
       Region 6fuy A 398-401 disorder
       Region 6fuy A 402-415 order
       Region 6fuy A 416-462 disorder
       Region 6fuy A 463-835 order
       Region 6fuy A 836-879 disorder
       Region 6fuy A 880-890 order
       Region 6fuy A 891-894 disorder
       Region 6fuy A 895-915 order
       Region 6fuy A 984-1115 order
       Region 6fuy A 1116-1121 disorder
       Region 6fuy A 1122-1134 order
Seq 1-258,882-915,984-1134 Hetero dimer :
 Evidence X-RAY 1rke A Reference
       Region 1rke A 1-258 order
 Evidence X-RAY 1rke B Reference
       Region 1rke B 882-915 order
       Region 1rke B 984-1074 order
       Region 1rke B 1075-1080 disorder
       Region 1rke B 1081-1131 order
       Region 1rke B 1132-1134 disorder
Seq 854-870 Hetero dimer : P56945
 Evidence NMR 5o2q A Reference
       Region 5o2q A 854-870 order
       Region 5o2q A 854-854 high_rmsd
       Region 5o2q A 868-870 high_rmsd
Seq 856-1134 Hetero dimer : Q8IY67
 Evidence X-RAY 3h2u A Reference
       Region 3h2u A 879-881 disorder
       Region 3h2u A 882-915 order
       Region 3h2u A 984-1131 order
       Region 3h2u A 1132-1134 disorder
 Evidence X-RAY 3h2u C Reference
       Region 3h2u C 879-882 disorder
       Region 3h2u C 883-888 order
       Region 3h2u C 889-891 disorder
       Region 3h2u C 892-915 order
       Region 3h2u C 984-1117 order
       Region 3h2u C 1118-1121 disorder
       Region 3h2u C 1122-1131 order
       Region 3h2u C 1132-1134 disorder
 Evidence X-RAY 3vf0 A Reference
       Region 3vf0 A 856-956 disorder
       Region 3vf0 A 957-1134 order
Seq 857-867 Hetero dimer : Q9BX66
 Evidence X-RAY 4ln2 B Reference
       Region 4ln2 B 857-857 disorder
       Region 4ln2 B 858-867 order
Seq 870-879 Hetero dimer : Q9BX66
 Evidence X-RAY 4lnp B Reference
       Region 4lnp B 870-879 order
Seq 879-915,984-1134 Hetero dimer : Q8IY67
 Evidence X-RAY 3h2v A Reference
       Region 3h2v A 879-883 disorder
       Region 3h2v A 884-888 order
       Region 3h2v A 889-892 disorder
       Region 3h2v A 893-915 order
       Region 3h2v A 984-1129 order
       Region 3h2v A 1130-1134 disorder
 Evidence X-RAY 3h2v B Reference
       Region 3h2v B 879-883 disorder
       Region 3h2v B 884-887 order
       Region 3h2v B 888-891 disorder
       Region 3h2v B 892-915 order
       Region 3h2v B 984-1113 order
       Region 3h2v B 1114-1122 disorder
       Region 3h2v B 1123-1131 order
       Region 3h2v B 1132-1134 disorder
 Evidence X-RAY 3h2v C Reference
       Region 3h2v C 879-883 disorder
       Region 3h2v C 884-887 order
       Region 3h2v C 888-892 disorder
       Region 3h2v C 893-915 order
       Region 3h2v C 984-1114 order
       Region 3h2v C 1115-1122 disorder
       Region 3h2v C 1123-1131 order
       Region 3h2v C 1132-1134 disorder
 Evidence X-RAY 3h2v D Reference
       Region 3h2v D 879-883 disorder
       Region 3h2v D 884-887 order
       Region 3h2v D 888-892 disorder
       Region 3h2v D 893-915 order
       Region 3h2v D 984-1131 order
       Region 3h2v D 1132-1134 disorder
Seq 959-1134 Homo dimer :
 Evidence X-RAY 4pr9 A Reference
       Region 4pr9 A 959-1133 order
       Region 4pr9 A 1134-1134 disorder
 Evidence X-RAY 4pr9 B Reference
       Region 4pr9 B 959-1134 order
 Evidence X-RAY 4pr9 C Reference
       Region 4pr9 C 959-1132 order
       Region 4pr9 C 1133-1134 disorder
 Evidence X-RAY 4pr9 D Reference
       Region 4pr9 D 959-1134 order
 Evidence X-RAY 4pr9 E Reference
       Region 4pr9 E 959-960 disorder
       Region 4pr9 E 961-1132 order
       Region 4pr9 E 1133-1134 disorder
 Evidence X-RAY 4pr9 F Reference
       Region 4pr9 F 959-961 disorder
       Region 4pr9 F 962-1112 order
       Region 4pr9 F 1113-1119 disorder
       Region 4pr9 F 1120-1126 order
       Region 4pr9 F 1127-1130 disorder
       Region 4pr9 F 1131-1132 order
       Region 4pr9 F 1133-1134 disorder
 Evidence X-RAY 5l0c A Reference
       Region 5l0c A 959-1134 order
 Evidence X-RAY 5l0c B Reference
       Region 5l0c B 959-1133 order
       Region 5l0c B 1134-1134 disorder
 Evidence X-RAY 5l0c C Reference
       Region 5l0c C 959-1133 order
       Region 5l0c C 1134-1134 disorder
 Evidence X-RAY 5l0c D Reference
       Region 5l0c D 959-1112 order
       Region 5l0c D 1113-1122 disorder
       Region 5l0c D 1123-1134 order
 Evidence X-RAY 5l0d A Reference
       Region 5l0d A 959-959 disorder
       Region 5l0d A 960-1119 order
       Region 5l0d A 1120-1122 disorder
       Region 5l0d A 1123-1130 order
 Evidence X-RAY 5l0d B Reference
       Region 5l0d B 959-959 disorder
       Region 5l0d B 960-1119 order
       Region 5l0d B 1120-1120 disorder
       Region 5l0d B 1121-1130 order
 Evidence X-RAY 5l0d C Reference
       Region 5l0d C 959-1115 order
       Region 5l0d C 1116-1119 disorder
       Region 5l0d C 1120-1130 order
 Evidence X-RAY 5l0d D Reference
       Region 5l0d D 959-961 disorder
       Region 5l0d D 962-1114 order
       Region 5l0d D 1115-1117 disorder
       Region 5l0d D 1118-1130 order
 Evidence X-RAY 5l0g A Reference
       Region 5l0g A 959-959 disorder
       Region 5l0g A 960-1075 order
       Region 5l0g A 1076-1076 disorder
       Region 5l0g A 1077-1132 order
       Region 5l0g A 1133-1134 disorder
 Evidence X-RAY 5l0g B Reference
       Region 5l0g B 959-1118 order
       Region 5l0g B 1119-1120 disorder
       Region 5l0g B 1121-1132 order
       Region 5l0g B 1133-1134 disorder
 Evidence X-RAY 5l0g C Reference
       Region 5l0g C 959-1118 order
       Region 5l0g C 1119-1121 disorder
       Region 5l0g C 1122-1132 order
       Region 5l0g C 1133-1134 disorder
 Evidence X-RAY 5l0g D Reference
       Region 5l0g D 959-1075 order
       Region 5l0g D 1076-1077 disorder
       Region 5l0g D 1078-1118 order
       Region 5l0g D 1119-1121 disorder
       Region 5l0g D 1122-1133 order
       Region 5l0g D 1134-1134 disorder
 Evidence X-RAY 5l0j A Reference
       Region 5l0j A 969-1074 order
       Region 5l0j A 1075-1080 disorder
       Region 5l0j A 1081-1115 order
       Region 5l0j A 1116-1117 disorder
       Region 5l0j A 1118-1131 order
       Region 5l0j A 1132-1134 disorder
 Evidence X-RAY 5l0j B Reference
       Region 5l0j B 969-1074 order
       Region 5l0j B 1075-1080 disorder
       Region 5l0j B 1081-1132 order
       Region 5l0j B 1133-1134 disorder
Seq 959-1134 Monomer :
 Evidence X-RAY 3myi A Reference
       Region 3myi A 959-960 disorder
       Region 3myi A 961-1116 order
       Region 3myi A 1117-1122 disorder
       Region 3myi A 1123-1129 order
       Region 3myi A 1130-1130 disorder
 Evidence X-RAY 5l0f A Reference
       Region 5l0f A 959-1134 order
 Evidence X-RAY 5l0f B Reference
       Region 5l0f B 959-1134 order
 Evidence X-RAY 5l0h A Reference
       Region 5l0h A 959-959 disorder
       Region 5l0h A 960-1132 order
       Region 5l0h A 1133-1134 disorder
 Evidence X-RAY 5l0i A Reference
       Region 5l0i A 959-959 disorder
       Region 5l0i A 960-1134 order
SeqProS verified 855-867 The residues with high_rmsd are excluded from the ProS. Hetero dimer : P56945
       Region 5o2q A 854-870 order
       Region 1tr2 A 844-876 disorder
SeqProS verified 857-867 Hetero dimer : Q9BX66
       Region 4ln2 B 858-867 order
       Region 1tr2 A 844-876 disorder
SeqProS verified 870-876 Hetero dimer : Q9BX66
       Region 4lnp B 870-879 order
       Region 1tr2 A 844-876 disorder
Seqphosphorylation
    1133-1133 Phosphotyrosine; by SRC-type Tyr-kinases
    822-822 Phosphotyrosine
    809-809 Phosphoserine
    795-795 Phosphoserine
    721-721 Phosphoserine
    672-672 Phosphothreonine
    604-604 Phosphothreonine
    600-600 Phosphoserine
    579-579 Phosphoserine
    574-574 Phosphoserine
    537-537 Phosphotyrosine
    434-434 Phosphoserine
    346-346 Phosphoserine
    290-290 Phosphoserine
    288-288 Phosphoserine
    275-275 Phosphoserine
    272-272 Phosphoserine
    260-260 Phosphoserine
    97-97 Phosphoserine
Seqacetylation
    496-496 N6-acetyllysine
    173-173 N6-acetyllysine
 
Prediction
NeProc
Disorder 288-291,844-901,918-981,1078-1083,1130-1134
Order 1-287,292-843,902-917,982-1072,1084-1129
ProS 288-291,844-860,865-901,918-918,971-981,1130-1134
AlphaFold
Disorder 1-1,255-257,838-871,874-874,876-883,886-899,911-960,1008-1009,1134-1134
Order 2-254,258-837,872-873,875-875,884-885,900-910,961-1007,1010-1133
SEG 549-560 ,638-655 ,835-852 ,860-887 ,917-943
Function
Function in SwissProt
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.