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IID00929
 UniprotP18827
ProteinSyndecan-1
GeneSDC1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
310
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 201-212 Hetero dimer : Q86Y38
 Evidence X-RAY 6eje B Reference
       Region 6eje B 201-201 disorder
       Region 6eje B 202-210 order
       Region 6eje B 211-212 disorder
Seq 303-310 Hetero dimer : IID00971Complex
 Evidence X-RAY 4gvc B Reference
       Region 4gvc B 303-310 order
 Evidence X-RAY 4gvd D Reference
       Region 4gvd D 303-310 order
 Evidence X-RAY 4gvd C Reference
       Region 4gvd C 303-310 order
SeqProS predicted 202-210 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : Q86Y38
       Region 6eje B 202-210 order
SeqProS possible 303-310 Same region of the homolog (P31431) is disordered in the free state. Hetero dimer : IID00971Complex
       Region 4gvd C 303-310 order
       Region 4gvd D 303-310 order
       Region 4gvc B 303-310 order
Seqphosphorylation
    285-285 Phosphoserine
 
Prediction
NeProc
Disorder 1-247,282-310
Order 248-281
ProS 1-58,106-110,129-134,153-159,188-236,244-247,282-290,297-310
AlphaFold
Disorder 1-1,17-29,34-244,281-310
Order 2-16,30-33,245-280
SEG 4-23 ,33-50 ,128-151 ,252-265
Function
Function in SwissProt
Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity).