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IID00930
 UniprotP19544
ProteinWilms tumor protein
GeneWT1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
449
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 126-134 Hetero decamer : P04439
 Evidence X-RAY 6rsy C Reference
       Region 6rsy C 126-134 order
 Evidence X-RAY 6rsy H Reference
       Region 6rsy H 126-134 order
Seq 126-134 Hetero pentamer : P04439
 Evidence X-RAY 4wuu C Reference
       Region 4wuu C 126-134 order
Seq 126-134 Hetero pentamer : A0A140T913
 Evidence X-RAY 7bbg C Reference
       Region 7bbg C 126-134 order
Seq 126-134 Hetero trimer : P04439
 Evidence X-RAY 3hpj C Reference
       Region 3hpj C 126-134 order
 Evidence X-RAY 3hpj F Reference
       Region 3hpj F 126-134 order
 Evidence X-RAY 3myj C Reference
       Region 3myj C 126-134 order
 Evidence X-RAY 3myj F Reference
       Region 3myj F 126-134 order
Seq 318-440 Monomer :
 Evidence NMR 2jp9 A Reference
       Region 2jp9 A 318-407 order
       Region 2jp9 A 318-341 high_rmsd
       Region 2jp9 A 349-349 high_rmsd
       Region 2jp9 A 411-438 order
 Evidence NMR 2jpa A Reference
       Region 2jpa A 318-407 order
       Region 2jpa A 318-321 high_rmsd
       Region 2jpa A 411-438 order
 Evidence X-RAY 2prt A Reference
       Region 2prt A 318-320 disorder
       Region 2prt A 321-407 order
       Region 2prt A 411-438 order
 Evidence X-RAY 4r2e A Reference
       Region 4r2e A 350-407 order
       Region 4r2e A 411-440 order
 Evidence X-RAY 4r2p A Reference
       Region 4r2p A 350-407 order
       Region 4r2p A 411-440 order
 Evidence X-RAY 4r2q A Reference
       Region 4r2q A 350-407 order
       Region 4r2q A 411-439 order
       Region 4r2q A 440-440 disorder
 Evidence X-RAY 4r2r A Reference
       Region 4r2r A 350-407 order
       Region 4r2r A 411-439 order
       Region 4r2r A 440-440 disorder
 Evidence X-RAY 4r2s A Reference
       Region 4r2s A 350-407 order
       Region 4r2s A 411-440 order
 Evidence X-RAY 5kl2 A Reference
       Region 5kl2 A 350-407 order
       Region 5kl2 A 411-440 order
 Evidence X-RAY 5kl3 A Reference
       Region 5kl3 A 350-350 disorder
       Region 5kl3 A 351-407 order
       Region 5kl3 A 411-440 order
 Evidence X-RAY 5kl4 A Reference
       Region 5kl4 A 350-407 order
       Region 5kl4 A 411-440 order
 Evidence X-RAY 5kl4 D Reference
       Region 5kl4 D 350-350 disorder
       Region 5kl4 D 351-407 order
       Region 5kl4 D 411-439 order
       Region 5kl4 D 440-440 disorder
 Evidence X-RAY 5kl5 A Reference
       Region 5kl5 A 350-407 order
       Region 5kl5 A 411-439 order
       Region 5kl5 A 440-440 disorder
 Evidence X-RAY 5kl6 A Reference
       Region 5kl6 A 350-350 disorder
       Region 5kl6 A 351-407 order
       Region 5kl6 A 411-440 order
 Evidence X-RAY 5kl7 A Reference
       Region 5kl7 A 350-407 order
       Region 5kl7 A 411-439 order
       Region 5kl7 A 440-440 disorder
 Evidence X-RAY 6b0o A Reference
       Region 6b0o A 321-407 order
       Region 6b0o A 411-440 order
 Evidence X-RAY 6b0o D Reference
       Region 6b0o D 321-407 order
       Region 6b0o D 411-439 order
       Region 6b0o D 440-440 disorder
 Evidence X-RAY 6b0p D Reference
       Region 6b0p D 321-407 order
       Region 6b0p D 411-439 order
       Region 6b0p D 440-440 disorder
 Evidence X-RAY 6b0p A Reference
       Region 6b0p A 321-407 order
       Region 6b0p A 411-439 order
       Region 6b0p A 440-440 disorder
 Evidence X-RAY 6b0q D Reference
       Region 6b0q D 321-407 order
       Region 6b0q D 411-439 order
       Region 6b0q D 440-440 disorder
 Evidence X-RAY 6b0q A Reference
       Region 6b0q A 321-407 order
       Region 6b0q A 411-440 order
 Evidence X-RAY 6b0r D Reference
       Region 6b0r D 321-407 order
       Region 6b0r D 411-439 order
       Region 6b0r D 440-440 disorder
 Evidence X-RAY 6b0r A Reference
       Region 6b0r A 321-407 order
       Region 6b0r A 411-439 order
       Region 6b0r A 440-440 disorder
 Evidence X-RAY 6blw A Reference
       Region 6blw A 319-408 order
       Region 6blw A 409-414 disorder
       Region 6blw A 415-422 order
       Region 6blw A 423-430 disorder
       Region 6blw A 431-439 order
       Region 6blw A 440-440 disorder
 Evidence NMR 6wlh A Reference
       Region 6wlh A 318-407 order
       Region 6wlh A 318-321 high_rmsd
       Region 6wlh A 411-438 order
Seq 381-407 Monomer :
 Evidence NMR 1xf7 A Reference
       Region 1xf7 A 381-407 order
 
Prediction
NeProc
Disorder 1-92,99-278,434-449
Order 93-98,279-433
ProS 1-13,32-42,51-56,68-92,99-112,128-138,149-160,172-182,188-275,434-449
AlphaFold
Disorder 1-55,64-319,407-412,445-446,448-449
Order 56-63,320-406,413-444,447-447
Pfam Hmmer
323->347 1-321 353->377
SEG 41-68 ,110-125
Function
Function in SwissProt
Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).