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IID00934
 UniprotP29374
ProteinAT-rich interactive domain-containing protein 4A
GeneARID4A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1257
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-121 Monomer :
 Evidence NMR 2mam A Reference
       Region 2mam A 4-121 order
       Region 2mam A 4-29 high_rmsd
       Region 2mam A 91-121 high_rmsd
Seq 169-417 Homo dimer :
 Evidence X-RAY 7v8n A Reference
       Region 7v8n A 169-272 order
       Region 7v8n A 273-302 disorder
       Region 7v8n A 303-417 order
 Evidence X-RAY 7v8n B Reference
       Region 7v8n B 169-238 order
       Region 7v8n B 239-246 disorder
       Region 7v8n B 247-272 order
       Region 7v8n B 273-304 disorder
       Region 7v8n B 305-415 order
       Region 7v8n B 416-417 disorder
Seq 170-273 Monomer :
 Evidence NMR 2yrv A Reference
       Region 2yrv A 170-273 order
       Region 2yrv A 170-170 high_rmsd
       Region 2yrv A 269-273 high_rmsd
Seq 171-283,304-414 Monomer :
 Evidence NMR 6l87 A Reference
       Region 6l87 A 171-280 order
       Region 6l87 A 277-283 high_rmsd
       Region 6l87 A 304-414 order
       Region 6l87 A 388-391 high_rmsd
Seq 568-635 Monomer :
 Evidence NMR 2lcc A Reference
       Region 2lcc A 568-635 order
       Region 2lcc A 568-572 high_rmsd
       Region 2lcc A 614-616 high_rmsd
       Region 2lcc A 635-635 high_rmsd
 Evidence X-RAY 6bph A Reference
       Region 6bph A 568-569 disorder
       Region 6bph A 570-635 order
Seq 953-967 Hetero tetramer : IID00130Complex
 Evidence X-RAY 7smc B Reference
       Region 7smc B 953-956 disorder
       Region 7smc B 957-967 order
 Evidence X-RAY 7smc D Reference
       Region 7smc D 953-955 disorder
       Region 7smc D 956-962 order
       Region 7smc D 963-967 disorder
SeqProS predicted 956-967 LXCXE motif; this region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero tetramer : IID00130Complex
       Region 7smc B 957-967 order
       Region 7smc D 956-962 order
Seqphosphorylation
    676-676 Phosphoserine
    1109-1109 Phosphoserine
    1145-1145 Phosphoserine
    716-716 Phosphoserine
    864-864 Phosphoserine
 
Prediction
NeProc
Disorder 1-4,116-168,269-310,407-416,445-485,514-637,666-702,735-1178,1221-1257
Order 5-115,169-268,311-375,382-406,417-444,486-513,638-665,703-734,1179-1220
ProS 1-4,116-142,269-272,407-414,469-474,552-558,567-576,1167-1178,1252-1257
AlphaFold
Disorder 1-6,110-171,274-307,408-573,633-1168,1226-1257
Order 7-109,172-273,308-407,574-632,1169-1225
SEG 28-43 ,152-167 ,267-313 ,410-430 ,480-506 ,526-558 ,560-571 ,638-666 ,689-704 ,775-788 ,961-972 ,1211-1222 ,1225-1248
Function
Function in SwissProt
DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).