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IID00937
 UniprotP40855
ProteinPeroxisomal biogenesis factor 19
GenePEX19
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
299
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-44
 Evidence CD Reference
       Region 1-44 disorder
Seq 1-44 Hetero dimer : P56589
 Evidence X-RAY 3ajb B Reference
       Region 3ajb B 1-14 disorder
       Region 3ajb B 15-40 order
       Region 3ajb B 41-44 disorder
Seqdisorder 1-156
 Evidence CD Reference
       Region 1-156 disorder
Seq 14-33 Hetero dimer : P56589
 Evidence X-RAY 3mk4 B Reference
       Region 3mk4 B 14-30 order
       Region 3mk4 B 31-33 disorder
Seq 66-77 Hetero dimer : IID00919Complex
 Evidence NMR 2w85 B Reference
       Region 2w85 B 66-77 order
Seq 161-299 Monomer :
 Evidence X-RAY 2wl8 A Reference
       Region 2wl8 A 161-170 disorder
       Region 2wl8 A 171-280 order
       Region 2wl8 A 281-283 disorder
 Evidence X-RAY 2wl8 B Reference
       Region 2wl8 B 161-170 disorder
       Region 2wl8 B 171-274 order
       Region 2wl8 B 275-283 disorder
 Evidence X-RAY 2wl8 C Reference
       Region 2wl8 C 161-170 disorder
       Region 2wl8 C 171-279 order
       Region 2wl8 C 280-283 disorder
 Evidence X-RAY 2wl8 D Reference
       Region 2wl8 D 161-170 disorder
       Region 2wl8 D 171-279 order
       Region 2wl8 D 280-283 disorder
 Evidence NMR 5lnf A Reference
       Region 5lnf A 161-299 order
       Region 5lnf A 161-167 high_rmsd
       Region 5lnf A 289-289 high_rmsd
Seqdisorder 290-299
 Evidence NMR Low {1H}-15N heteronuclear NOE values and large solvent paramagnetic relaxation enhancements (solvent PREs) for the C-terminal ten residues in the non-farnesylated PEX19 CTD indicate that they are highly flexible in solution and solvent exposed, respectively. Reference
       Region 290-299 disorder
SeqProS verified 14-30 Hetero dimer : P56589
       Region 3mk4 B 14-30 order
       Region 1-44 disorder
SeqProS verified 15-33 The residues (Pro34-Ser40) in 3ajb, fixed by molecular contacts with an adjacent Pex3p molecule in the crystal packing arrangement (PMID: 21102411), are excluded from the ProS. Hetero dimer : P56589
       Region 3ajb B 15-40 order
       Region 1-44 disorder
SeqProS verified 66-77 Hetero dimer : IID00919Complex
       Region 2w85 B 66-77 order
       Region 1-156 disorder
SeqProS verified 290-299 Cys296-farnesylation induces a substantial rigidification and compaction of the PEX19 CTD (PMID: 28281558). :
       Region 5lnf A 161-299 order
       Region 290-299 disorder
Seqphosphorylation
    54-54 Phosphoserine
    35-35 Phosphoserine
    66-66 Phosphoserine
    236-236 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-178,272-299
Order 179-271
ProS 14-31,85-90,125-136,272-283,294-299
AlphaFold
Disorder 1-13,32-78,80-80,115-117,138-154,156-171,270-299
Order 14-31,79-79,81-114,118-137,155-155,172-269
SEG 12-48 ,157-169 ,252-261
Function
Function in SwissProt
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.