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IID00939
 UniprotP46108
ProteinAdapter molecule crk
GeneCRK
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
304
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-304 Monomer :
 Evidence NMR 2dvj A Reference
       Region 2dvj A 1-228 order
 Evidence NMR 2eyy A Reference
       Region 2eyy A 1-204 order
 Evidence NMR 2eyz A Reference
       Region 2eyz A 1-304 order
Seq 6-124 Monomer :
 Evidence NMR 2eyv A Reference
       Region 2eyv A 6-124 order
Seq 12-120 Hetero trimer : IID00645Complex,Q64010
 Evidence NMR 1ju5 A Reference
       Region 1ju5 A 12-120 order
Seq 125-198 Monomer :
 Evidence NMR 2eyw A Reference
       Region 2eyw A 125-198 order
Seq 134-191 Hetero dimer : Q99AU3
 Evidence X-RAY 5ul6 A Reference
       Region 5ul6 A 134-191 order
 Evidence X-RAY 6atv A Reference
       Region 6atv A 134-191 order
Seqdisorder 192-223
 Evidence NMR The other region in the nSH3-cSH3 linker (residues 192-237), aside from the ISC (inter-SH3 core, residues 224-237) , is flexible. Reference
       Region 192-223 disorder
Seq 216-224 Hetero dimer : P62937
 Evidence NMR 2ms4 B Reference
       Region 2ms4 B 216-224 order
Seq 232-298 Monomer :
 Evidence NMR 2eyx A Reference
       Region 2eyx A 232-298 order
SeqProS verified 192-223 pY221 induced intramolecular interaction :
       Region 2dvj A 1-228 order
       Region 192-223 disorder
SeqProS verified 216-223 Hetero dimer : P62937
       Region 2ms4 B 216-224 order
       Region 192-223 disorder
Seqphosphorylation
    41-41 Phosphoserine
    194-194 Phosphoserine
    40-40 Phosphoserine
    74-74 Phosphoserine
    83-83 Phosphoserine
    108-108 Phosphotyrosine
    125-125 Phosphoserine
    221-221 Phosphotyrosine; by ABL1
    239-239 Phosphotyrosine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-3,74-81,110-132,195-236,296-304
Order 4-73,82-109,133-194,237-295
ProS 1-3,110-121,199-211,217-231,300-304
AlphaFold
Disorder 1-4,65-85,120-134,191-237,248-253,270-272,295-304
Order 5-64,86-119,135-190,238-247,254-269,273-294
Pfam Hmmer
135->190 13-104 239->294
SEG 64-86
Function
Function in SwissProt
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.
Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity).
Biological Process
Diagram with PDB data
CRKphosphorylated Crk-II