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IID00941
 UniprotP49023
ProteinPaxillin
GenePXN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
591
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-10 Hetero trimer : IID90020Complex,P06931
 Evidence X-RAY 3py7 A Reference
       Region 3py7 A 1-10 order
Seq 1-20 Hetero dimer : Q9NVD7
 Evidence X-RAY 2vzd C Reference
       Region 2vzd C 1-1 disorder
       Region 2vzd C 2-13 order
       Region 2vzd C 14-20 disorder
 Evidence X-RAY 2vzd D Reference
       Region 2vzd D 1-14 order
       Region 2vzd D 15-20 disorder
 Evidence NMR 2k2r B Reference
       Region 2k2r B 3-12 order
Seq 1-20 Hetero heptadecamer : Q9HBI1
 Evidence X-RAY 4edn K Reference
       Region 4edn K 1-1 disorder
       Region 4edn K 2-13 order
       Region 4edn K 14-20 disorder
 Evidence X-RAY 4edn L Reference
       Region 4edn L 1-19 order
       Region 4edn L 20-20 disorder
 Evidence X-RAY 4edn M Reference
       Region 4edn M 1-2 disorder
       Region 4edn M 3-12 order
       Region 4edn M 13-20 disorder
 Evidence X-RAY 4edn N Reference
       Region 4edn N 1-1 disorder
       Region 4edn N 2-13 order
       Region 4edn N 14-20 disorder
 Evidence X-RAY 4edn O Reference
       Region 4edn O 1-12 order
       Region 4edn O 13-20 disorder
 Evidence X-RAY 4edn P Reference
       Region 4edn P 1-1 disorder
       Region 4edn P 2-12 order
       Region 4edn P 13-20 disorder
 Evidence X-RAY 4edn Q Reference
       Region 4edn Q 1-14 order
       Region 4edn Q 15-20 disorder
Seqdisorder 1-20
 Evidence CD CD spectra of LD1, LD3 and LD5 peptides showed characteristics of random coil. Reference
       Region 1-20 disorder
Seq 2-15 Hetero pentamer : Q9BUL8
 Evidence X-RAY 3rqe E Reference
       Region 3rqe E 2-4 disorder
       Region 3rqe E 5-14 order
       Region 3rqe E 15-15 disorder
Seq 45-54 Hetero dimer : Q9BX66
 Evidence X-RAY 2o9v B Reference
       Region 2o9v B 45-54 order
Seq 139-160 Hetero trimer : Q14289
 Evidence X-RAY 4r32 B Reference
       Region 4r32 B 139-142 disorder
       Region 4r32 B 143-153 order
       Region 4r32 B 154-160 disorder
 Evidence X-RAY 4r32 C Reference
       Region 4r32 C 139-139 disorder
       Region 4r32 C 140-154 order
       Region 4r32 C 155-160 disorder
Seq 141-153 Hetero pentamer : Q9BUL8
 Evidence X-RAY 3rqf E Reference
       Region 3rqf E 141-142 disorder
       Region 3rqf E 143-153 order
Seq 141-153 Hetero dimer : Q05397
 Evidence X-RAY 6pw8 B Reference
       Region 6pw8 B 141-149 order
       Region 6pw8 B 150-150 disorder
       Region 6pw8 B 151-153 order
Seq 141-153 Hetero pentamer : Q05397
 Evidence X-RAY 1ow8 D Reference
       Region 1ow8 D 141-141 disorder
       Region 1ow8 D 142-153 order
 Evidence X-RAY 1ow8 F Reference
       Region 1ow8 F 141-141 disorder
       Region 1ow8 F 142-153 order
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz w Reference
       Region 4xgz w 141-152 order
       Region 4xgz w 153-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz m Reference
       Region 4xgz m 141-153 order
       Region 4xgz m 154-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz a Reference
       Region 4xgz a 141-152 order
       Region 4xgz a 153-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz e Reference
       Region 4xgz e 141-153 order
       Region 4xgz e 154-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz q Reference
       Region 4xgz q 141-159 order
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz g Reference
       Region 4xgz g 141-153 order
       Region 4xgz g 154-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz o Reference
       Region 4xgz o 141-152 order
       Region 4xgz o 153-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz s Reference
       Region 4xgz s 141-152 order
       Region 4xgz s 153-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz c Reference
       Region 4xgz c 141-156 order
       Region 4xgz c 157-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz u Reference
       Region 4xgz u 141-153 order
       Region 4xgz u 154-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz h Reference
       Region 4xgz h 141-152 order
       Region 4xgz h 153-159 disorder
Seq 141-159 Hetero trimer :
 Evidence X-RAY 4xgz j Reference
       Region 4xgz j 141-159 order
Seq 141-160 Hetero dimer : Q9NVD7
 Evidence X-RAY 2vzg A Reference
       Region 2vzg A 141-155 order
       Region 2vzg A 156-160 disorder
Seqdisorder 213-232
 Evidence CD CD spectra of LD1, LD3 and LD5 peptides showed characteristics of random coil. Reference
       Region 213-232 disorder
Seq 261-275 Hetero trimer :
 Evidence X-RAY 4xh2 g Reference
       Region 4xh2 g 261-274 order
       Region 4xh2 g 275-275 disorder
Seq 261-275 Hetero trimer :
 Evidence X-RAY 4xh2 a Reference
       Region 4xh2 a 261-275 order
Seq 261-275 Hetero trimer :
 Evidence X-RAY 4xh2 c Reference
       Region 4xh2 c 261-261 disorder
       Region 4xh2 c 262-272 order
       Region 4xh2 c 273-275 disorder
Seq 261-275 Hetero trimer :
 Evidence X-RAY 4xh2 j Reference
       Region 4xh2 j 261-261 disorder
       Region 4xh2 j 262-273 order
       Region 4xh2 j 274-275 disorder
Seq 261-275 Hetero trimer :
 Evidence X-RAY 4xh2 e Reference
       Region 4xh2 e 261-275 order
Seq 261-275 Hetero trimer :
 Evidence X-RAY 4xh2 h Reference
       Region 4xh2 h 261-272 order
       Region 4xh2 h 273-275 disorder
Seq 261-277 Hetero dimer : Q14289
 Evidence X-RAY 3u3f G Reference
       Region 3u3f G 261-272 order
       Region 3u3f G 273-277 disorder
 Evidence X-RAY 3u3f H Reference
       Region 3u3f H 261-274 order
       Region 3u3f H 275-277 disorder
Seq 261-277 Hetero trimer : Q14289
 Evidence X-RAY 3gm1 E Reference
       Region 3gm1 E 262-263 disorder
       Region 3gm1 E 264-274 order
 Evidence X-RAY 3gm1 F Reference
       Region 3gm1 F 262-274 order
 Evidence X-RAY 3gm1 C Reference
       Region 3gm1 C 262-263 disorder
       Region 3gm1 C 264-274 order
 Evidence X-RAY 3gm1 D Reference
       Region 3gm1 D 262-262 disorder
       Region 3gm1 D 263-274 order
 Evidence X-RAY 3u3f E Reference
       Region 3u3f E 261-273 order
       Region 3u3f E 274-277 disorder
 Evidence X-RAY 3u3f I Reference
       Region 3u3f I 261-264 disorder
       Region 3u3f I 265-274 order
       Region 3u3f I 275-277 disorder
 Evidence X-RAY 3u3f F Reference
       Region 3u3f F 261-273 order
       Region 3u3f F 274-277 disorder
 Evidence X-RAY 3u3f J Reference
       Region 3u3f J 261-264 disorder
       Region 3u3f J 265-274 order
       Region 3u3f J 275-277 disorder
Seq 261-280 Hetero tetramer : Q9Z272
 Evidence X-RAY 6iui C Reference
       Region 6iui C 261-280 order
 Evidence X-RAY 6iui D Reference
       Region 6iui D 261-280 order
Seq 262-274 Hetero hexamer : Q05397
 Evidence X-RAY 1ow6 D Reference
       Region 1ow6 D 262-262 disorder
       Region 1ow6 D 263-274 order
 Evidence X-RAY 1ow6 F Reference
       Region 1ow6 F 262-262 disorder
       Region 1ow6 F 263-273 order
       Region 1ow6 F 274-274 disorder
Seq 262-274 Hetero pentamer : Q9BUL8
 Evidence X-RAY 3rqg E Reference
       Region 3rqg E 262-273 order
       Region 3rqg E 274-274 disorder
Seq 262-274 Hetero hexamer : Q05397
 Evidence X-RAY 1ow7 D Reference
       Region 1ow7 D 262-262 disorder
       Region 1ow7 D 263-274 order
 Evidence X-RAY 1ow7 E Reference
       Region 1ow7 E 262-262 disorder
       Region 1ow7 E 263-274 order
 Evidence X-RAY 1ow7 F Reference
       Region 1ow7 F 262-262 disorder
       Region 1ow7 F 263-274 order
Seq 262-277 Hetero dimer : Q9NVD7
 Evidence X-RAY 2vzi A Reference
       Region 2vzi A 262-274 order
       Region 2vzi A 275-277 disorder
Seq 264-277 Hetero tetramer : IID50169Complex
 Evidence X-RAY 5uwh D Reference
       Region 5uwh D 264-264 disorder
       Region 5uwh D 265-277 order
Seqdisorder 330-349
 Evidence CD CD spectra of LD1, LD3 and LD5 peptides showed characteristics of random coil. Reference
       Region 330-349 disorder
Seq 414-533 Monomer :
 Evidence NMR 7qb0 A Reference
       Region 7qb0 A 414-533 order
       Region 7qb0 A 414-416 high_rmsd
       Region 7qb0 A 421-427 high_rmsd
       Region 7qb0 A 450-452 high_rmsd
       Region 7qb0 A 511-512 high_rmsd
       Region 7qb0 A 532-533 high_rmsd
Seq 527-591 Monomer :
 Evidence NMR 6u4m A Reference
       Region 6u4m A 527-591 order
       Region 6u4m A 527-529 high_rmsd
Seq 527-591 Hetero dimer : Q96AC1
 Evidence NMR 6u4n B Reference
       Region 6u4n B 527-591 order
       Region 6u4n B 527-529 high_rmsd
SeqProS verified 1-19 Hetero dimer : Q9NVD7
       Region 2k2r B 3-12 order
       Region 2vzd C 2-13 order
       Region 2vzd D 1-14 order
       Region 1-20 disorder
SeqProS verified 1-19 Hetero trimer : IID90020Complex,P06931
       Region 3py7 A 1-10 order
       Region 1-20 disorder
SeqProS verified 1-19 Hetero heptadecamer : Q9HBI1
       Region 4edn K 2-13 order
       Region 4edn L 1-19 order
       Region 4edn M 3-12 order
       Region 4edn N 2-13 order
       Region 4edn O 1-12 order
       Region 4edn P 2-12 order
       Region 4edn Q 1-14 order
       Region 1-20 disorder
SeqProS verified 1-19 Hetero pentamer : Q9BUL8
       Region 3rqe E 5-14 order
       Region 1-20 disorder
SeqProS predicted 45-54 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : Q9BX66
       Region 2o9v B 45-54 order
SeqProS possible 140-155 The LD2 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero trimer : Q14289
       Region 4r32 B 143-153 order
       Region 4r32 C 140-154 order
SeqProS possible 140-155 The LD2 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero pentamer : Q9BUL8
       Region 3rqf E 143-153 order
SeqProS possible 140-155 The LD2 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero pentamer : Q05397
       Region 1ow8 D 142-153 order
       Region 1ow8 F 142-153 order
SeqProS possible 140-155 The LD2 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero dimer : Q9NVD7
       Region 2vzg A 141-155 order
SeqProS possible 261-280 The LD4 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero tetramer : Q9Z272
       Region 6iui C 261-280 order
       Region 6iui D 261-280 order
SeqProS possible 261-280 The LD4 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero trimer : Q14289
       Region 3u3f E 261-273 order
       Region 3u3f F 261-273 order
       Region 3u3f I 265-274 order
       Region 3u3f J 265-274 order
       Region 3gm1 C 264-274 order
       Region 3gm1 D 263-274 order
       Region 3gm1 E 264-274 order
       Region 3gm1 F 262-274 order
SeqProS possible 261-280 The LD4 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero dimer : Q9NVD7
       Region 2vzi A 262-274 order
SeqProS possible 261-280 The LD4 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero hexamer : Q05397
       Region 1ow6 D 263-274 order
       Region 1ow6 F 263-273 order
SeqProS possible 261-280 The LD4 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero pentamer : Q9BUL8
       Region 3rqg E 262-273 order
SeqProS possible 261-280 The LD4 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero dimer : Q14289
       Region 3u3f G 261-272 order
       Region 3u3f H 261-274 order
SeqProS possible 261-280 The LD4 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero hexamer : Q05397
       Region 1ow7 D 263-274 order
       Region 1ow7 E 263-274 order
       Region 1ow7 F 263-274 order
SeqProS possible 261-280 The LD4 motif region of chicken paxillin (P49024) is shown to be verified ProS. Hetero tetramer : IID50169Complex
       Region 5uwh D 265-277 order
Seqphosphorylation
    303-303 Phosphoserine
    31-31 Phosphotyrosine; by PTK6
    83-83 Phosphoserine
    85-85 Phosphoserine
    88-88 Phosphotyrosine
    106-106 Phosphoserine
    258-258 Phosphoserine
    533-533 Phosphoserine
    340-340 Phosphoserine
    332-332 Phosphoserine
    322-322 Phosphoserine
    272-272 Phosphoserine
    261-261 Phosphoserine
    118-118 Phosphotyrosine; by PTK6
    250-250 Phosphoserine; by SLK
    230-230 Phosphoserine
    244-244 Phosphoserine; by CDK5
    143-143 Phosphoserine
    181-181 Phosphotyrosine
    140-140 Phosphoserine
    137-137 Phosphoserine
    132-132 Phosphothreonine
    130-130 Phosphoserine
    126-126 Phosphoserine
    119-119 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-341
Order 342-591
ProS 1-34,57-65,140-154,212-223,275-281,297-302,324-341
AlphaFold
Disorder 1-2,11-142,155-216,220-220,226-262,273-273,275-333,345-345,348-353
Order 3-10,143-154,217-219,221-225,263-272,274-274,334-344,346-347,354-591
Pfam Hmmer
358->414 44-253 417->473
SEG 2-11 ,45-53 ,138-153 ,169-180 ,215-231 ,316-332
Function
Function in SwissProt
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion.