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IID00942
 UniprotP49418
ProteinAmphiphysin
GeneAMPH
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
695
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-242 Homo dimer :
 Evidence X-RAY 4atm A Reference
       Region 4atm A 1-18 disorder
       Region 4atm A 19-239 order
       Region 4atm A 240-242 disorder
 Evidence X-RAY 3sog A Reference
       Region 3sog A 34-35 disorder
       Region 3sog A 36-157 order
       Region 3sog A 158-160 disorder
       Region 3sog A 161-235 order
       Region 3sog A 236-236 disorder
Seq 322-330 Hetero dimer : P17427
 Evidence X-RAY 1ky7 P Reference
       Region 1ky7 P 322-330 order
Seq 349-360 Hetero trimer : P49951
 Evidence X-RAY 5m5s E Reference
       Region 5m5s E 349-355 order
       Region 5m5s E 356-358 disorder
 Evidence X-RAY 5m5s G Reference
       Region 5m5s G 349-358 order
 Evidence X-RAY 5m5s F Reference
       Region 5m5s F 349-355 order
       Region 5m5s F 356-358 disorder
 Evidence X-RAY 5m5s H Reference
       Region 5m5s H 349-358 order
 Evidence X-RAY 5m61 E Reference
       Region 5m61 E 349-357 order
       Region 5m61 E 358-360 disorder
 Evidence X-RAY 5m61 G Reference
       Region 5m61 G 349-360 order
 Evidence X-RAY 5m61 F Reference
       Region 5m61 F 349-357 order
       Region 5m61 F 358-360 disorder
 Evidence X-RAY 5m61 H Reference
       Region 5m61 H 349-360 order
Seq 379-387 Hetero dimer : P49951
 Evidence X-RAY 1utc P Reference
       Region 1utc P 379-385 order
       Region 1utc P 386-387 disorder
 Evidence X-RAY 1utc Q Reference
       Region 1utc Q 379-385 order
       Region 1utc Q 386-387 disorder
Seqdisorder 381-385
 Evidence X-RAY Reference
       Region 381-385 disorder
SeqProS verified 381-385 Hetero dimer : P49951
       Region 1utc P 379-385 order
       Region 1utc Q 379-385 order
       Region 381-385 disorder
Seqphosphorylation
    252-252 Phosphoserine
    260-260 Phosphothreonine
    262-262 Phosphoserine
    268-268 Phosphoserine
    272-272 Phosphoserine
    276-276 Phosphoserine
    280-280 Phosphothreonine
    506-506 Phosphoserine
    638-638 Phosphoserine
 
Prediction
NeProc
Disorder 1-9,240-618
Order 10-239,619-695
ProS 1-9,240-246,351-358,380-386,405-422,452-456,463-491,502-505,512-559,567-570,588-595
AlphaFold
Disorder 1-7,9-9,31-31,241-617
Order 8-8,10-30,32-240,618-695
SEG 260-277 ,282-295 ,301-315 ,483-495
Function
Function in SwissProt
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.