Search Keyword:


Search option:


IID00944
 UniprotP50542
ProteinPeroxisomal targeting signal 1 receptor
GenePEX5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
639
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-110
 Evidence NMR NMR fingerprint spectra of 15N-labeled Pex5-(1-110) show very little dispersion, characteristic of an unstructured protein. However, upon addition of unlabeled Pex14-NTD, the spectrum changes significantly, indicating a strong interaction between Pex5-(1-110) and Pex14-NTD (Fig. 2A). Reference
       Region 1-110 disorder
Seq 57-71 Hetero dimer : IID00919Complex
 Evidence NMR 4bxu B Reference
       Region 4bxu B 57-71 order
Seq 108-127 Hetero dimer : IID00919Complex
 Evidence NMR 2w84 B Reference
       Region 2w84 B 108-127 order
Seqdisorder 179-192
 Evidence X-RAY 7z0k B Reference
       Region 7z0k B 179-192 disorder
Seq 179-192 Hetero tetramer : IID01002Complex
 Evidence X-RAY 7z0k A Reference
       Region 7z0k A 179-180 disorder
       Region 7z0k A 181-190 order
       Region 7z0k A 191-192 disorder
Seq 272-639 Hetero dimer :
 Evidence X-RAY 1fch A Reference
       Region 1fch A 272-316 disorder
       Region 1fch A 317-441 order
       Region 1fch A 442-456 disorder
       Region 1fch A 457-589 order
       Region 1fch A 590-595 disorder
       Region 1fch A 596-639 order
Seq 272-639 Hetero dimer :
 Evidence X-RAY 1fch B Reference
       Region 1fch B 272-321 disorder
       Region 1fch B 322-442 order
       Region 1fch B 443-456 disorder
       Region 1fch B 457-589 order
       Region 1fch B 590-596 disorder
       Region 1fch B 597-639 order
Seq 315-639 Homo dimer :
 Evidence X-RAY 2j9q A Reference
       Region 2j9q A 315-442 order
       Region 2j9q A 443-465 disorder
       Region 2j9q A 466-591 order
       Region 2j9q A 592-596 disorder
       Region 2j9q A 597-639 order
 Evidence X-RAY 2j9q B Reference
       Region 2j9q B 315-352 disorder
       Region 2j9q B 353-442 order
       Region 2j9q B 443-460 disorder
       Region 2j9q B 461-639 order
Seq 315-639 Hetero tetramer : P21549
 Evidence X-RAY 3r9a B Reference
       Region 3r9a B 315-324 disorder
       Region 3r9a B 325-440 order
       Region 3r9a B 441-464 disorder
       Region 3r9a B 465-590 order
       Region 3r9a B 591-592 disorder
       Region 3r9a B 593-639 order
 Evidence X-RAY 3r9a D Reference
       Region 3r9a D 315-323 disorder
       Region 3r9a D 324-443 order
       Region 3r9a D 444-460 disorder
       Region 3r9a D 461-589 order
       Region 3r9a D 590-596 disorder
       Region 3r9a D 597-639 order
 Evidence X-RAY 4kxk B Reference
       Region 4kxk B 315-324 disorder
       Region 4kxk B 325-440 order
       Region 4kxk B 441-464 disorder
       Region 4kxk B 465-589 order
       Region 4kxk B 590-592 disorder
       Region 4kxk B 593-639 order
 Evidence X-RAY 4kxk D Reference
       Region 4kxk D 315-324 disorder
       Region 4kxk D 325-440 order
       Region 4kxk D 441-464 disorder
       Region 4kxk D 465-589 order
       Region 4kxk D 590-592 disorder
       Region 4kxk D 593-639 order
 Evidence X-RAY 4kyo B Reference
       Region 4kyo B 315-324 disorder
       Region 4kyo B 325-440 order
       Region 4kyo B 441-464 disorder
       Region 4kyo B 465-589 order
       Region 4kyo B 590-594 disorder
       Region 4kyo B 595-639 order
 Evidence X-RAY 4kyo D Reference
       Region 4kyo D 315-324 disorder
       Region 4kyo D 325-440 order
       Region 4kyo D 441-464 disorder
       Region 4kyo D 465-589 order
       Region 4kyo D 590-595 disorder
       Region 4kyo D 596-639 order
Seq 321-639 Monomer :
 Evidence X-RAY 2c0m A Reference
       Region 2c0m A 321-442 order
       Region 2c0m A 443-464 disorder
       Region 2c0m A 465-639 order
 Evidence X-RAY 2c0m B Reference
       Region 2c0m B 321-442 order
       Region 2c0m B 443-464 disorder
       Region 2c0m B 465-639 order
 Evidence X-RAY 2c0m C Reference
       Region 2c0m C 321-321 disorder
       Region 2c0m C 322-440 order
       Region 2c0m C 441-456 disorder
       Region 2c0m C 457-639 order
 Evidence X-RAY 2c0m F Reference
       Region 2c0m F 321-321 disorder
       Region 2c0m F 322-440 order
       Region 2c0m F 441-456 disorder
       Region 2c0m F 457-639 order
Seq 335-639 Hetero dimer : P22307
 Evidence X-RAY 2c0l A Reference
       Region 2c0l A 335-440 order
       Region 2c0l A 441-453 disorder
       Region 2c0l A 454-639 order
SeqProS verified 57-71 Hetero dimer : IID00919Complex
       Region 4bxu B 57-71 order
       Region 1-110 disorder
SeqProS predicted 108-127 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : IID00919Complex
       Region 2w84 B 108-127 order
SeqProS verified 181-190 Hetero tetramer : IID01002Complex
       Region 7z0k A 181-190 order
       Region 7z0k B 179-192 disorder
Seqphosphorylation
    115-115 Phosphoserine
    141-141 Phosphoserine; by ATM
    153-153 Phosphoserine
    279-279 Phosphoserine
    167-167 Phosphoserine
    155-155 Phosphoserine
 
Prediction
NeProc
Disorder 1-12,19-295,303-311,448-454
Order 13-18,296-302,312-447,455-594,600-639
ProS 1-12,19-37,60-68,80-93,115-121,140-146,158-163,208-231,240-295,303-311,448-454
AlphaFold
Disorder 1-56,62-63,65-88,90-192,227-244,246-282,295-295,297-319,442-463,589-598
Order 57-61,64-64,89-89,193-226,245-245,283-294,296-296,320-441,464-588,599-639
SEG 443-453
Function
Function in SwissProt
Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:7706321, PubMed:7719337, PubMed:7790377, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:21976670, PubMed:26344566, PubMed:11101887, PubMed:17157249, PubMed:17428317). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:21976670, PubMed:26344566, PubMed:17157249). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292).
In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:9668159, PubMed:11336669, PubMed:11546814, PubMed:25538232, PubMed:33389129). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed:25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed:25538232).
Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal.