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IID00946
 UniprotP52597
ProteinHeterogeneous nuclear ribonucleoprotein F
GeneHNRNPF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
415
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-102 Monomer :
 Evidence NMR 2hgl A Reference
       Region 2hgl A 1-102 order
       Region 2hgl A 1-8 disorder
       Region 2hgl A 1-8 high_rmsd
       Region 2hgl A 9-102 order
       Region 2hgl A 101-102 high_rmsd
 Evidence NMR 2kfy A Reference
       Region 2kfy A 1-102 order
       Region 2kfy A 1-8 disorder
       Region 2kfy A 1-8 high_rmsd
       Region 2kfy A 9-102 order
       Region 2kfy A 49-49 high_rmsd
       Region 2kfy A 54-54 high_rmsd
       Region 2kfy A 102-102 high_rmsd
Seq 2-10 Hetero dimer : Q9GZZ1
 Evidence X-RAY 3tfy D Reference
       Region 3tfy D 2-5 order
       Region 3tfy D 6-10 disorder
 Evidence X-RAY 3tfy E Reference
       Region 3tfy E 2-5 order
       Region 3tfy E 6-10 disorder
 Evidence X-RAY 3tfy F Reference
       Region 3tfy F 2-5 order
       Region 3tfy F 6-10 disorder
Seq 103-194 Monomer :
 Evidence NMR 2hgm A Reference
       Region 2hgm A 103-194 order
       Region 2hgm A 103-104 high_rmsd
 Evidence NMR 2kg0 A Reference
       Region 2kg0 A 103-194 order
       Region 2kg0 A 103-106 high_rmsd
Seq 277-381 Monomer :
 Evidence NMR 2kg1 A Reference
       Region 2kg1 A 277-381 order
       Region 2kg1 A 277-287 high_rmsd
       Region 2kg1 A 323-324 high_rmsd
       Region 2kg1 A 369-381 high_rmsd
 Evidence NMR 2hgn A Reference
       Region 2hgn A 277-286 disorder
       Region 2hgn A 287-367 order
       Region 2hgn A 368-381 disorder
SeqProS verified 2-5 Hetero dimer : Q9GZZ1
       Region 3tfy D 2-5 order
       Region 3tfy E 2-5 order
       Region 3tfy F 2-5 order
       Region 2hgl A 1-8 disorder
Seqphosphorylation
    265-265 Phosphoserine
    215-215 Phosphothreonine
    195-195 Phosphoserine
    193-193 Phosphoserine
    187-187 Phosphoserine
    161-161 Phosphoserine
    107-107 Phosphoserine
    104-104 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein F; alternate
    224-224 N6-acetyllysine; alternate
    200-200 N6-acetyllysine; alternate
    2-2 N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein F
 
Prediction
NeProc
Disorder 1-7,100-105,198-284,366-415
Order 8-99,106-197,285-365
ProS 100-105,198-270,275-284,366-375,388-415
AlphaFold
Disorder 1-10,49-49,99-110,138-139,147-148,188-287,364-415
Order 11-48,50-98,111-137,140-146,149-187,288-363
Pfam Hmmer
255->290 113-183 291->359
SEG 234-254
Function
Function in SwissProt
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.