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IID00948
 UniprotP52948
ProteinNuclear pore complex protein Nup98-Nup96
GeneNUP98
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1817
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-1817 Hetero hexamer : P78406
 Evidence X-RAY 7f90 B Reference
       Region 7f90 B 1-157 disorder
       Region 7f90 B 158-171 order
       Region 7f90 B 172-182 disorder
       Region 7f90 B 183-213 order
       Region 7f90 B 214-1817 disorder
 Evidence X-RAY 7f90 D Reference
       Region 7f90 D 1-157 disorder
       Region 7f90 D 158-172 order
       Region 7f90 D 173-182 disorder
       Region 7f90 D 183-213 order
       Region 7f90 D 214-1817 disorder
Seq 1-1817 Hetero hexamer : P0DTC6,P78406
 Evidence X-RAY 7f60 C Reference
       Region 7f60 C 1-157 disorder
       Region 7f60 C 158-171 order
       Region 7f60 C 172-179 disorder
       Region 7f60 C 180-213 order
       Region 7f60 C 214-1817 disorder
 Evidence X-RAY 7f60 D Reference
       Region 7f60 D 1-157 disorder
       Region 7f60 D 158-173 order
       Region 7f60 D 174-177 disorder
       Region 7f60 D 178-213 order
       Region 7f60 D 214-1817 disorder
Seq 157-213 Hetero trimer : P78406,Q8B0H7
 Evidence X-RAY 4owr B Reference
       Region 4owr B 157-157 disorder
       Region 4owr B 158-174 order
       Region 4owr B 175-176 disorder
       Region 4owr B 177-213 order
Seq 158-213 Hetero dimer : P78406
 Evidence X-RAY 3mmy B Reference
       Region 3mmy B 158-173 order
       Region 3mmy B 174-178 disorder
       Region 3mmy B 179-213 order
 Evidence X-RAY 3mmy D Reference
       Region 3mmy D 158-173 order
       Region 3mmy D 174-178 disorder
       Region 3mmy D 179-213 order
 Evidence X-RAY 3mmy F Reference
       Region 3mmy F 158-173 order
       Region 3mmy F 174-178 disorder
       Region 3mmy F 179-213 order
 Evidence X-RAY 3mmy H Reference
       Region 3mmy H 158-158 disorder
       Region 3mmy H 159-173 order
       Region 3mmy H 174-178 disorder
       Region 3mmy H 179-213 order
Seq 158-213 Hetero dodecamer : P0DTC6,P78406
 Evidence X-RAY 7vph B Reference
       Region 7vph B 158-173 order
       Region 7vph B 174-178 disorder
       Region 7vph B 179-213 order
 Evidence X-RAY 7vph D Reference
       Region 7vph D 158-170 order
       Region 7vph D 171-182 disorder
       Region 7vph D 183-213 order
 Evidence X-RAY 7vph F Reference
       Region 7vph F 158-174 order
       Region 7vph F 175-176 disorder
       Region 7vph F 177-213 order
 Evidence X-RAY 7vph H Reference
       Region 7vph H 158-169 order
       Region 7vph H 170-179 disorder
       Region 7vph H 180-213 order
Seq 158-213 Hetero dodecamer : P59634,P78406
 Evidence X-RAY 7vpg B Reference
       Region 7vpg B 158-174 order
       Region 7vpg B 175-178 disorder
       Region 7vpg B 179-213 order
 Evidence X-RAY 7vpg D Reference
       Region 7vpg D 158-172 order
       Region 7vpg D 173-180 disorder
       Region 7vpg D 181-213 order
 Evidence X-RAY 7vpg F Reference
       Region 7vpg F 158-174 order
       Region 7vpg F 175-176 disorder
       Region 7vpg F 177-213 order
 Evidence X-RAY 7vpg H Reference
       Region 7vpg H 158-173 order
       Region 7vpg H 174-178 disorder
       Region 7vpg H 179-213 order
Seq 695-931,937-941 Hetero tetramer :
 Evidence X-RAY 1ko6 A Reference
       Region 1ko6 A 695-728 disorder
       Region 1ko6 A 729-880 order
 Evidence X-RAY 1ko6 C Reference
       Region 1ko6 C 695-729 disorder
       Region 1ko6 C 730-755 order
       Region 1ko6 C 756-758 disorder
       Region 1ko6 C 759-880 order
 Evidence X-RAY 1ko6 B Reference
       Region 1ko6 B 881-881 disorder
       Region 1ko6 B 882-887 order
       Region 1ko6 B 888-931 disorder
       Region 1ko6 B 937-941 disorder
 Evidence X-RAY 1ko6 D Reference
       Region 1ko6 D 881-881 disorder
       Region 1ko6 D 882-887 order
       Region 1ko6 D 888-931 disorder
       Region 1ko6 D 937-941 disorder
Seq 729-880 Hetero dimer :
 Evidence X-RAY 2q5y C Reference
       Region 2q5y C 729-803 order
       Region 2q5y C 804-807 disorder
       Region 2q5y C 808-880 order
Seq 729-880 Hetero dimer :
 Evidence X-RAY 2q5y A Reference
       Region 2q5y A 729-880 order
Seq 732-880 Hetero tetramer : Q99567
 Evidence X-RAY 7mni B Reference
       Region 7mni B 732-880 order
 Evidence X-RAY 7mni D Reference
       Region 7mni D 732-880 order
Seq 733-887 Monomer :
 Evidence X-RAY 2q5x A Reference
       Region 2q5x A 733-803 order
       Region 2q5x A 804-807 disorder
       Region 2q5x A 808-887 order
Seq 881-887
 Evidence X-RAY 2q5y B Reference
       Region 2q5y B 881-882 disorder
       Region 2q5y B 883-885 order
       Region 2q5y B 886-887 disorder
Seq 881-887
 Evidence X-RAY 2q5y D Reference
       Region 2q5y D 881-882 disorder
       Region 2q5y D 883-885 order
       Region 2q5y D 886-887 disorder
Seqphosphorylation
    524-524 Phosphoserine
    608-608 Phosphoserine
    612-612 Phosphoserine
    618-618 Phosphoserine
    623-623 Phosphoserine
    625-625 Phosphoserine
    653-653 Phosphoserine
    670-670 Phosphothreonine
    673-673 Phosphoserine
    681-681 Phosphoserine
    1772-1772 Phosphothreonine
    1329-1329 Phosphoserine
    1070-1070 Phosphothreonine
    1064-1064 Phosphoserine
    1060-1060 Phosphoserine
    1043-1043 Phosphoserine
    1028-1028 Phosphoserine
    1023-1023 Phosphoserine
    1000-1000 Phosphothreonine
    934-934 Phosphoserine
    897-897 Phosphoserine
    888-888 Phosphoserine
    839-839 Phosphoserine
    683-683 Phosphoserine
Seqacetylation
    603-603 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-731,892-1115,1164-1180,1762-1775
Order 732-891,1116-1163,1181-1285,1293-1481,1487-1707,1713-1761,1776-1817
ProS 1-4,185-213,575-579,634-640,679-686,726-731,892-897,929-940,951-966,979-1018,1022-1035,1044-1052,1060-1066,1111-1115,1175-1180
AlphaFold
Disorder 1-158,213-730,732-732,757-757,887-1211,1231-1231,1257-1264,1284-1293,1367-1367,1455-1460,1472-1487,1592-1592,1677-1678,1680-1681,1684-1684,1707-1716,1759-1789,1807-1817
Order 159-212,731-731,733-756,758-886,1212-1230,1232-1256,1265-1283,1294-1366,1368-1454,1461-1471,1488-1591,1593-1676,1679-1679,1682-1683,1685-1706,1717-1758,1790-1806
SEG 5-45 ,73-87 ,115-138 ,257-272 ,330-358 ,396-417 ,427-444 ,594-610 ,926-935 ,1764-1775
Function
Function in SwissProt
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134).
(Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133).