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IID00951
 UniprotP55957
ProteinBH3-interacting domain death agonist
GeneBID
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
195
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-195 Monomer :
 Evidence NMR 2bid A Reference
       Region 2bid A 1-195 order
Seqdisorder 1-12,43-77
 Evidence NMR Loops 1-12 and 43-77 are not displayed in the figure because they are completely disordered. Reference
       Region 1-12 disorder
       Region 43-77 disorder
Seq 61-195 Monomer :
 Evidence NMR 2m5i A Reference
       Region 2m5i A 61-195 order
       Region 2m5i A 61-145 high_rmsd
       Region 2m5i A 182-195 high_rmsd
Seq 76-106 Hetero dimer : IID00970Complex
 Evidence NMR 2kbw B Reference
       Region 2kbw B 76-106 order
       Region 2kbw B 106-106 high_rmsd
Seq 76-109 Hetero dimer : IID00720Complex
 Evidence X-RAY 4qve B Reference
       Region 4qve B 76-76 disorder
       Region 4qve B 77-104 order
       Region 4qve B 105-109 disorder
Seq 76-109 Hetero decamer : P03182
 Evidence X-RAY 7p33 F Reference
       Region 7p33 F 76-78 disorder
       Region 7p33 F 79-98 order
       Region 7p33 F 99-109 disorder
 Evidence X-RAY 7p33 G Reference
       Region 7p33 G 76-106 order
       Region 7p33 G 107-109 disorder
 Evidence X-RAY 7p33 H Reference
       Region 7p33 H 76-77 disorder
       Region 7p33 H 78-107 order
       Region 7p33 H 108-109 disorder
 Evidence X-RAY 7p33 I Reference
       Region 7p33 I 76-78 disorder
       Region 7p33 I 79-101 order
       Region 7p33 I 102-109 disorder
 Evidence X-RAY 7p33 J Reference
       Region 7p33 J 76-101 order
       Region 7p33 J 102-109 disorder
Seq 76-109 Hetero dimer : Q76RI8
 Evidence X-RAY 7qtw B Reference
       Region 7qtw B 76-76 disorder
       Region 7qtw B 77-104 order
       Region 7qtw B 105-109 disorder
Seq 76-109 Hetero tetramer : Q07812
 Evidence X-RAY 4bd2 C Reference
       Region 4bd2 C 76-105 order
       Region 4bd2 C 106-109 disorder
 Evidence X-RAY 4zii C Reference
       Region 4zii C 76-99 order
       Region 4zii C 100-109 disorder
Seq 79-98 Hetero tetramer : Q07812
 Evidence X-RAY 4zig B Reference
       Region 4zig B 79-98 order
Seq 79-104 Hetero dimer : Q16548
 Evidence X-RAY 4zeq B Reference
       Region 4zeq B 79-104 order
Seq 79-112 Hetero tetramer : Q85365
 Evidence X-RAY 5ajj B Reference
       Region 5ajj B 79-80 disorder
       Region 5ajj B 81-109 order
       Region 5ajj B 110-112 disorder
Seq 80-100 Hetero tetramer : Q16611
 Evidence X-RAY 7m5b B Reference
       Region 7m5b B 80-100 order
 Evidence X-RAY 7m5b D Reference
       Region 7m5b D 80-80 disorder
       Region 7m5b D 81-100 order
Seq 80-101 Hetero dimer : Q16611
 Evidence NMR 2m5b B Reference
       Region 2m5b B 80-101 order
 Evidence X-RAY 7m5a B Reference
       Region 7m5a B 80-100 order
Seq 80-101 Hetero dimer : IID00970Complex
 Evidence X-RAY 5c3f B Reference
       Region 5c3f B 80-101 order
Seq 82-101 Hetero dimer : Q92843
 Evidence NMR 1zy3 B Reference
       Region 1zy3 B 82-101 order
Seqphosphorylation
    78-78 Phosphoserine
    54-54 Phosphotyrosine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-8
Order 9-195
ProS 1-8
AlphaFold
Disorder 1-15,27-36,38-38,40-80,97-107,109-110,112-121,123-124,134-135,137-142,159-164,190-195
Order 16-26,37-37,39-39,81-96,108-108,111-111,122-122,125-133,136-136,143-158,165-189
SEG 149-160
Function
Function in SwissProt
Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity).
Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622).
Induces ICE-like proteases and apoptosis.
Induces ICE-like proteases and apoptosis.
Does not induce apoptosis.
Induces ICE-like proteases and apoptosis.