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IID00952
 UniprotP56962
ProteinSyntaxin-17
GeneSTX17
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
302
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 142-228
 Evidence NMR¸ CD Reference
       Region 142-228 disorder
Seq 142-228 Hetero 24mer : O95721,Q9BV40
 Evidence X-RAY 7bv6 B Reference
       Region 7bv6 B 142-167 disorder
       Region 7bv6 B 168-228 order
 Evidence X-RAY 7bv6 F Reference
       Region 7bv6 F 142-167 disorder
       Region 7bv6 F 168-228 order
 Evidence X-RAY 7bv6 J Reference
       Region 7bv6 J 142-167 disorder
       Region 7bv6 J 168-226 order
       Region 7bv6 J 227-228 disorder
 Evidence X-RAY 7bv6 N Reference
       Region 7bv6 N 142-167 disorder
       Region 7bv6 N 168-227 order
       Region 7bv6 N 228-228 disorder
 Evidence X-RAY 7bv6 R Reference
       Region 7bv6 R 142-167 disorder
       Region 7bv6 R 168-222 order
       Region 7bv6 R 223-228 disorder
 Evidence X-RAY 7bv6 V Reference
       Region 7bv6 V 142-167 disorder
       Region 7bv6 V 168-227 order
       Region 7bv6 V 228-228 disorder
Seq 167-188 Hetero octamer : IID00921Complex
 Evidence X-RAY 7bv4 C Reference
       Region 7bv4 C 167-168 disorder
       Region 7bv4 C 169-183 order
       Region 7bv4 C 184-188 disorder
 Evidence X-RAY 7bv4 D Reference
       Region 7bv4 D 167-168 disorder
       Region 7bv4 D 169-183 order
       Region 7bv4 D 184-188 disorder
 Evidence X-RAY 7bv4 F Reference
       Region 7bv4 F 167-169 disorder
       Region 7bv4 F 170-184 order
       Region 7bv4 F 185-188 disorder
 Evidence X-RAY 7bv4 H Reference
       Region 7bv4 H 167-169 disorder
       Region 7bv4 H 170-184 order
       Region 7bv4 H 185-188 disorder
Seq 170-227 Hetero tetramer : O95721,Q9BV40
 Evidence X-RAY 4wy4 B Reference
       Region 4wy4 B 170-227 order
SeqProS verified 168-228 Hetero : O95721,Q9BV40
       Region 7bv6 B 168-228 order
       Region 7bv6 F 168-228 order
       Region 7bv6 J 168-226 order
       Region 7bv6 N 168-227 order
       Region 7bv6 R 168-222 order
       Region 7bv6 V 168-227 order
       Region 142-228 disorder
SeqProS verified 168-228 Hetero tetramer : O95721,Q9BV40
       Region 4wy4 B 170-227 order
       Region 142-228 disorder
SeqProS verified 169-184 Hetero octamer : IID00921Complex
       Region 7bv4 C 169-183 order
       Region 7bv4 D 169-183 order
       Region 7bv4 F 170-184 order
       Region 7bv4 H 170-184 order
       Region 142-228 disorder
Seqphosphorylation
    157-157 Phosphotyrosine; by ABL1
    289-289 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
    41-41 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-7,104-165,213-228,252-255,276-302
Order 8-103,166-212,229-251,256-275
ProS 104-127,134-140,152-165,213-228,252-255,276-296
AlphaFold
Disorder 1-5,110-158,196-302
Order 6-109,159-195
SEG 74-89 ,219-232 ,256-274
Function
Function in SwissProt
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).