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IID00955
UniprotP60520
ProteinGamma-aminobutyric acid receptor-associated protein-like 2
GeneGABARAPL2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
117
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-116 Hetero dimer : IID01016Complex
 Evidence NMR 6h8c A Reference
       Region 6h8c A 1-116 order
Seq 1-116 Hetero dimer : IID50450Complex
 Evidence X-RAY 7yo8 A Reference
       Region 7yo8 A 1-116 order
Seq 1-117 Homo dimer :
 Evidence X-RAY 7lk3 A Reference
       Region 7lk3 A 1-117 order
 Evidence X-RAY 7lk3 B Reference
       Region 7lk3 B 1-117 order
Seq 1-117 Monomer :
 Evidence X-RAY 4co7 A Reference
       Region 4co7 A 1-117 order
 Evidence X-RAY 4co7 B Reference
       Region 4co7 B 1-117 order
Seqphosphorylation
    39-39 Phosphoserine
    87-87 Phosphoserine; by TBK1
    88-88 Phosphoserine; by TBK1
Seqacetylation
    24-24 N6-acetyllysine
 
Prediction
NeProc
Order 1-85,91-117
AlphaFold
Disorder 115-117
Order 1-114
Function
Function in SwissProt
Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295).