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IID00956
 UniprotP62328
ProteinThymosin beta-4
GeneTMSB4X
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
44
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-44
 Evidence NMR NMR at 25 degree Celsius; In contrast with data obtained at 2 degree Celsius, no NOE correlation indicative of any secondary structure was found at 25 degree Celsius. Reference
       Region 1-44 disorder
Seq 2-44 Hetero trimer : IID50082Complex
 Evidence X-RAY 4pl8 H Reference
       Region 4pl8 H 2-4 disorder
       Region 4pl8 H 5-26 order
       Region 4pl8 H 27-44 disorder
Seq 2-44 Hetero dimer : Q9P4D1
 Evidence X-RAY 4pl7 B Reference
       Region 4pl7 B 2-5 disorder
       Region 4pl7 B 6-41 order
       Region 4pl7 B 42-44 disorder
Seq 2-44 Hetero dimer : Q9P4D1
 Evidence X-RAY 4pl7 A Reference
       Region 4pl7 A 2-5 disorder
       Region 4pl7 A 6-41 order
       Region 4pl7 A 42-44 disorder
Seqdisorder 21-44
 Evidence X-RAY 3tu5 B Reference
       Region 3tu5 B 21-44 disorder
SeqProS verified 5-41 Hetero dimer : Q9P4D1
       Region 4pl7 B 6-41 order
       Region 1-44 disorder
SeqProS verified 5-41 Hetero dimer : Q9P4D1
       Region 4pl7 A 6-41 order
       Region 1-44 disorder
SeqProS verified 5-41 Hetero trimer : IID50082Complex
       Region 4pl8 H 5-26 order
       Region 1-44 disorder
Seqphosphorylation
    2-2 Phosphoserine
    23-23 Phosphothreonine
    31-31 Phosphoserine
    34-34 Phosphothreonine
Seqacetylation
    2-2 N-acetylserine
    4-4 N6-acetyllysine
    12-12 N6-acetyllysine; alternate
    26-26 N6-acetyllysine
    32-32 N6-acetyllysine
    39-39 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-44
ProS 1-38
AlphaFold
Disorder 1-5,43-44
Order 6-42
Function
Function in SwissProt
Plays an important role in the organization of the cytoskeleton (PubMed:1999398, PubMed:10848969). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:1999398, PubMed:10848969).
Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).