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IID00957
 UniprotP63252
ProteinInward rectifier potassium channel 2
GeneKCNJ2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
427
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 422-427 Hetero trimer : IID00960Complex
 Evidence X-RAY 6spz P Reference
       Region 6spz P 422-427 order
 Evidence X-RAY 6spz Q Reference
       Region 6spz Q 422-427 order
SeqProS possible 422-427 PDZ domain-binding motif; this region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero trimer : IID00960Complex
       Region 6spz P 422-427 order
       Region 6spz Q 422-427 order
 
Prediction
NeProc
Disorder 1-40,365-427
Order 41-364
ProS 4-12,17-21,27-35,373-380,405-409,416-427
AlphaFold
Disorder 1-44,372-376,384-427
Order 45-371,377-383
Function
Function in SwissProt
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (PubMed:7590287, PubMed:7696590, PubMed:7840300). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:9490857, PubMed:7590287, PubMed:36149965). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:7696590, PubMed:7590287). The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:9490857). Can be blocked by extracellular barium or cesium (PubMed:7696590, PubMed:7590287).