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IID00958
 UniprotP67775
ProteinSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
GenePPP2CA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
309
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-309 Hetero trimer : P30153,P63151
 Evidence X-RAY 3dw8 C Reference
       Region 3dw8 C 1-5 disorder
       Region 3dw8 C 6-293 order
       Region 3dw8 C 294-309 disorder
 Evidence X-RAY 3dw8 F Reference
       Region 3dw8 F 1-5 disorder
       Region 3dw8 F 6-293 order
       Region 3dw8 F 294-309 disorder
Seq 1-309 Hetero trimer : P30153,Q15257
 Evidence X-RAY 4lac C Reference
       Region 4lac C 1-3 disorder
       Region 4lac C 4-293 order
       Region 4lac C 294-309 disorder
Seq 1-309 Hetero trimer : IID00975Complex,Q76MZ3
 Evidence X-RAY 2iae C Reference
       Region 2iae C 1-3 disorder
       Region 2iae C 4-309 order
 Evidence X-RAY 2iae F Reference
       Region 2iae F 1-3 disorder
       Region 2iae F 4-294 order
       Region 2iae F 295-309 disorder
Seq 1-309 Hetero dimer : P30153
 Evidence X-RAY 2ie3 C Reference
       Region 2ie3 C 1-5 disorder
       Region 2ie3 C 6-293 order
       Region 2ie3 C 294-309 disorder
 Evidence X-RAY 2ie4 C Reference
       Region 2ie4 C 1-5 disorder
       Region 2ie4 C 6-293 order
       Region 2ie4 C 294-309 disorder
 Evidence X-RAY 3k7v C Reference
       Region 3k7v C 1-5 disorder
       Region 3k7v C 6-293 order
       Region 3k7v C 294-309 disorder
 Evidence X-RAY 3k7w C Reference
       Region 3k7w C 1-5 disorder
       Region 3k7w C 6-293 order
       Region 3k7w C 294-309 disorder
Seq 1-309 Hetero trimer : P30153,Q9Y5P8
 Evidence X-RAY 4i5l C Reference
       Region 4i5l C 1-1 disorder
       Region 4i5l C 2-296 order
       Region 4i5l C 297-309 disorder
 Evidence X-RAY 4i5l F Reference
       Region 4i5l F 1-1 disorder
       Region 4i5l F 2-296 order
       Region 4i5l F 297-309 disorder
 Evidence X-RAY 4i5n C Reference
       Region 4i5n C 1-1 disorder
       Region 4i5n C 2-294 order
       Region 4i5n C 295-309 disorder
 Evidence X-RAY 4i5n F Reference
       Region 4i5n F 1-2 disorder
       Region 4i5n F 3-296 order
       Region 4i5n F 297-309 disorder
Seq 1-309 Hetero pentamer : P30153,Q9Y570
 Evidence X-RAY 3c5w C Reference
       Region 3c5w C 1-5 disorder
       Region 3c5w C 6-293 order
       Region 3c5w C 294-303 disorder
       Region 3c5w C 304-309 order
Seq 1-309 Hetero trimer : IID00975Complex,P30153
 Evidence X-RAY 2npp F Reference
       Region 2npp F 1-1 disorder
       Region 2npp F 2-309 order
 Evidence X-RAY 2npp C Reference
       Region 2npp C 1-1 disorder
       Region 2npp C 2-309 order
 Evidence X-RAY 2nyl C Reference
       Region 2nyl C 2-294 order
 Evidence X-RAY 2nyl F Reference
       Region 2nyl F 2-294 order
 Evidence X-RAY 2nym C Reference
       Region 2nym C 2-294 order
 Evidence X-RAY 2nym F Reference
       Region 2nym F 2-294 order
Seq 1-309 Hetero trimer : P30153,Q8BH58
 Evidence X-RAY 5w0w C Reference
       Region 5w0w C 1-3 disorder
       Region 5w0w C 4-295 order
       Region 5w0w C 296-303 disorder
       Region 5w0w C 304-309 order
 Evidence X-RAY 5w0w F Reference
       Region 5w0w F 1-4 disorder
       Region 5w0w F 5-294 order
       Region 5w0w F 295-303 disorder
       Region 5w0w F 304-309 order
 Evidence X-RAY 5w0w I Reference
       Region 5w0w I 1-4 disorder
       Region 5w0w I 5-294 order
       Region 5w0w I 295-303 disorder
       Region 5w0w I 304-309 order
 Evidence X-RAY 5w0w L Reference
       Region 5w0w L 1-4 disorder
       Region 5w0w L 5-293 order
       Region 5w0w L 294-302 disorder
       Region 5w0w L 303-309 order
Seq 1-292,298-309 Hetero dimer : Q9UIC8
 Evidence X-RAY 3p71 C Reference
       Region 3p71 C 1-1 disorder
       Region 3p71 C 2-292 order
       Region 3p71 C 298-309 order
Seq 1-309 Hetero tetramer : IID00975Complex,IID00983Complex,Q76MZ3
 Evidence X-RAY 3fga C Reference
       Region 3fga C 1-1 disorder
       Region 3fga C 2-295 order
       Region 3fga C 296-300 disorder
       Region 3fga C 301-309 order
Seq 6-153 Hetero dimer : P78318
 Evidence X-RAY 4iyp C Reference
       Region 4iyp C 6-42 order
       Region 4iyp C 43-54 disorder
       Region 4iyp C 55-57 order
       Region 4iyp C 58-59 disorder
       Region 4iyp C 60-69 order
       Region 4iyp C 70-76 disorder
       Region 4iyp C 77-88 order
       Region 4iyp C 89-91 disorder
       Region 4iyp C 92-117 order
       Region 4iyp C 118-122 disorder
       Region 4iyp C 123-153 order
Seq 304-309 Hetero dimer : Q15257
 Evidence X-RAY 4ny3 C Reference
       Region 4ny3 C 304-304 disorder
       Region 4ny3 C 305-309 order
 Evidence X-RAY 4ny3 D Reference
       Region 4ny3 D 304-304 disorder
       Region 4ny3 D 305-309 order
SeqProS verified 294-309 Hetero trimer : IID00975Complex,P30153
       Region 2npp C 2-309 order
       Region 2npp F 2-309 order
       Region 3k7v C 294-309 disorder
SeqProS verified 294-309 Hetero trimer : IID00975Complex,Q76MZ3
       Region 2iae C 4-309 order
       Region 3k7v C 294-309 disorder
SeqProS verified 294-309 Hetero tetramer : IID00975Complex,IID00983Complex,Q76MZ3
       Region 3fga C 301-309 order
       Region 3k7v C 294-309 disorder
SeqProS verified 298-309 Hetero dimer : Q9UIC8
       Region 3p71 C 298-309 order
       Region 3k7v C 294-309 disorder
SeqProS verified 303-309 Hetero trimer : P30153,Q8BH58
       Region 5w0w C 304-309 order
       Region 5w0w F 304-309 order
       Region 5w0w I 304-309 order
       Region 5w0w L 303-309 order
       Region 3k7v C 294-309 disorder
SeqProS verified 304-309 Hetero pentamer : P30153,Q9Y570
       Region 3c5w C 304-309 order
       Region 3k7v C 294-309 disorder
SeqProS verified 305-309 Hetero dimer : Q15257
       Region 4ny3 C 305-309 order
       Region 4ny3 D 305-309 order
       Region 3k7v C 294-309 disorder
Seqphosphorylation
    307-307 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-6,296-309
Order 7-295
ProS 303-309
AlphaFold
Disorder 1-1,295-309
Order 2-294
Function
Function in SwissProt
PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53 (PubMed:17245430). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity).
Biological Process
See also
Diagram with PDB data
FOXO3/YWHAECrystal Structure of 14-3-3 epsilon with FOXO3a peptide
FOXO1/SFN14-3-3 sigma in complex with FOXO1 pT24 peptide
Diagram without PDB data
FOXO4Stress signals in FOXO regulation