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IID00966
 UniprotQ04637
ProteinEukaryotic translation initiation factor 4 gamma 1
GeneEIF4G1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1599
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 161-216
 Evidence NMR Reference
       Region 161-216 disorder
Seq 172-199 Hetero tetramer : P03536
 Evidence X-RAY 1lj2 C Reference
       Region 1lj2 C 172-177 disorder
       Region 1lj2 C 178-199 order
 Evidence X-RAY 1lj2 D Reference
       Region 1lj2 D 172-172 disorder
       Region 1lj2 D 173-199 order
Seq 178-203 Hetero dimer : IID00193Complex
 Evidence X-RAY 4f02 C Reference
       Region 4f02 C 178-178 disorder
       Region 4f02 C 179-198 order
       Region 4f02 C 199-203 disorder
 Evidence X-RAY 4f02 F Reference
       Region 4f02 F 178-178 disorder
       Region 4f02 F 179-198 order
       Region 4f02 F 199-203 disorder
Seq 592-653 Hetero dimer : IID00341Complex
 Evidence X-RAY 5t46 B Reference
       Region 5t46 B 592-607 disorder
       Region 5t46 B 608-642 order
       Region 5t46 B 643-653 disorder
 Evidence X-RAY 5t46 D Reference
       Region 5t46 D 592-606 disorder
       Region 5t46 D 607-642 order
       Region 5t46 D 643-653 disorder
Seq 609-622 Hetero tetramer : IID00341Complex
 Evidence X-RAY 2w97 E Reference
       Region 2w97 E 609-621 order
       Region 2w97 E 622-622 disorder
 Evidence X-RAY 2w97 F Reference
       Region 2w97 F 609-609 disorder
       Region 2w97 F 610-621 order
       Region 2w97 F 622-622 disorder
Seq 609-623 Hetero dimer : IID00341Complex
 Evidence X-RAY 4aza B Reference
       Region 4aza B 609-620 order
 Evidence X-RAY 4aza D Reference
       Region 4aza D 609-620 order
 Evidence X-RAY 5ehc B Reference
       Region 5ehc B 609-622 order
 Evidence X-RAY 5eir B Reference
       Region 5eir B 609-622 order
 Evidence X-RAY 5ei3 B Reference
       Region 5ei3 B 609-622 order
 Evidence X-RAY 5zk5 B Reference
       Region 5zk5 B 609-609 disorder
       Region 5zk5 B 610-618 order
       Region 5zk5 B 619-619 disorder
       Region 5zk5 B 620-622 order
       Region 5zk5 B 623-623 disorder
Seq 1233-1571 Monomer :
 Evidence X-RAY 1ug3 A Reference
       Region 1ug3 A 1233-1426 order
       Region 1ug3 A 1427-1436 disorder
       Region 1ug3 A 1437-1565 order
       Region 1ug3 A 1566-1571 disorder
 Evidence X-RAY 1ug3 B Reference
       Region 1ug3 B 1233-1426 order
       Region 1ug3 B 1427-1436 disorder
       Region 1ug3 B 1437-1565 order
       Region 1ug3 B 1566-1571 disorder
SeqProS verified 173-199 Hetero tetramer : P03536
       Region 1lj2 D 173-199 order
       Region 1lj2 C 178-199 order
       Region 161-216 disorder
SeqProS verified 179-198 Hetero dimer : IID00193Complex
       Region 4f02 C 179-198 order
       Region 4f02 F 179-198 order
       Region 161-216 disorder
SeqProS predicted 607-642 This region is predicted to be disordered by AlphaFold (pLDDT < 68.5) and NeProc. Hetero dimer : IID00341Complex
       Region 5t46 D 607-642 order
       Region 5t46 B 608-642 order
SeqProS predicted 609-621 This region is predicted to be disordered by AlphaFold (pLDDT < 68.5) and NeProc. Hetero tetramer : IID00341Complex
       Region 2w97 E 609-621 order
       Region 2w97 F 610-621 order
SeqProS predicted 609-622 This region is predicted to be disordered by AlphaFold (pLDDT < 68.5) and NeProc. Hetero dimer : IID00341Complex
       Region 5ehc B 609-622 order
       Region 5ei3 B 609-622 order
       Region 5eir B 609-622 order
       Region 4aza B 609-620 order
       Region 4aza D 609-620 order
       Region 5zk5 B 610-618 order
       Region 5zk5 B 620-622 order
Seqphosphorylation
    705-705 Phosphoserine
    509-509 Phosphoserine
    1596-1596 Phosphoserine
    1238-1238 Phosphoserine
    1231-1231 Phosphoserine
    1211-1211 Phosphothreonine
    1209-1209 Phosphoserine
    1187-1187 Phosphoserine
    1194-1194 Phosphoserine
    1147-1147 Phosphoserine
    1185-1185 Phosphoserine; by PKC/PRKCA
    1145-1145 Phosphoserine
    1092-1092 Phosphoserine
    1077-1077 Phosphoserine
    647-647 Phosphothreonine
    1028-1028 Phosphoserine
    223-223 Phosphothreonine
    314-314 Phosphoserine
    207-207 Phosphothreonine
    15-15 Phosphoserine
Seqacetylation
    2-2 N-acetylmethionine
    1095-1095 N6-acetyllysine
    602-602 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-449,478-622,634-756,861-862,997-1239,1430-1436,1592-1599
Order 450-477,623-633,757-860,863-996,1240-1429,1437-1591
ProS 30-34,102-106,529-533,594-622,634-644,663-670,721-737,861-862,997-1016,1044-1055,1064-1071,1090-1095,1119-1130,1164-1173
AlphaFold
Disorder 1-180,198-611,621-621,625-753,787-788,826-837,854-859,993-1002,1005-1005,1022-1236,1427-1439,1593-1599
Order 181-197,612-620,622-624,754-786,789-825,838-853,860-992,1003-1004,1006-1021,1237-1426,1440-1592
Pfam Hmmer
1242->1354 761-989 1518->1599
SEG 4-27 ,53-74 ,248-274 ,366-393 ,429-452 ,454-482 ,548-569 ,674-703 ,826-837 ,848-867 ,874-888 ,1026-1046 ,1088-1110 ,1155-1176 ,1184-1199 ,1233-1252 ,1375-1383 ,1522-1535
Function
Function in SwissProt
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139).
Biological Process
See also
Diagram with PDB data
EIF4EBP2NMR structure of Phosphorylated 4E-BP2