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IID00967
 UniprotQ05209
ProteinTyrosine-protein phosphatase non-receptor type 12
GenePTPN12
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
780
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-301 Monomer :
 Evidence X-RAY 5hde A Reference
       Region 5hde A 1-1 disorder
       Region 5hde A 2-301 order
Seq 1-305 Homo tetramer :
 Evidence X-RAY 5j8r A Reference
       Region 5j8r A 1-1 disorder
       Region 5j8r A 2-201 order
       Region 5j8r A 202-203 disorder
       Region 5j8r A 204-299 order
       Region 5j8r A 300-305 disorder
 Evidence X-RAY 5j8r B Reference
       Region 5j8r B 1-1 disorder
       Region 5j8r B 2-199 order
       Region 5j8r B 200-204 disorder
       Region 5j8r B 205-299 order
       Region 5j8r B 300-305 disorder
 Evidence X-RAY 5j8r C Reference
       Region 5j8r C 1-17 order
       Region 5j8r C 18-25 disorder
       Region 5j8r C 26-200 order
       Region 5j8r C 201-205 disorder
       Region 5j8r C 206-299 order
       Region 5j8r C 300-305 disorder
 Evidence X-RAY 5j8r D Reference
       Region 5j8r D 1-17 order
       Region 5j8r D 18-25 disorder
       Region 5j8r D 26-79 order
       Region 5j8r D 80-80 disorder
       Region 5j8r D 81-83 order
       Region 5j8r D 84-84 disorder
       Region 5j8r D 85-200 order
       Region 5j8r D 201-205 disorder
       Region 5j8r D 206-299 order
       Region 5j8r D 300-305 disorder
Seq 328-344 Hetero dimer : P56945
 Evidence NMR 5o2p A Reference
       Region 5o2p A 328-344 order
       Region 5o2p A 328-330 high_rmsd
       Region 5o2p A 342-344 high_rmsd
SeqProS predicted 331-341 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. The residues with high_rmsd are excluded from the ProS. Hetero dimer : P56945
       Region 5o2p A 328-344 order
Seqphosphorylation
    19-19 Phosphoserine
    332-332 Phosphoserine
    435-435 Phosphoserine
    449-449 Phosphoserine
    468-468 Phosphoserine
    519-519 Phosphothreonine
    509-509 Phosphothreonine
    567-567 Phosphoserine
    569-569 Phosphothreonine
    693-693 Phosphothreonine
    673-673 Phosphoserine
    689-689 Phosphoserine
    613-613 Phosphoserine
    608-608 Phosphoserine
    606-606 Phosphoserine
    603-603 Phosphoserine
    598-598 Phosphothreonine
    596-596 Phosphoserine
    571-571 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 302-757,763-780
Order 1-301,758-762
ProS 308-328,339-357,363-395,403-413,428-464,495-498,519-531,536-542,556-560,599-602,638-643,663-668,677-689,722-735,763-780
AlphaFold
Disorder 200-200,307-675,677-774,777-777,779-780
Order 1-199,201-306,676-676,775-776,778-778
SEG 333-338 ,359-375 ,520-529 ,603-609 ,622-642
Function
Function in SwissProt
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).
Biological Process
See also
Diagram with PDB data
SRCCRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP