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IID00968
 UniprotQ05586
ProteinGlutamate receptor ionotropic, NMDA 1
GeneGRIN1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
938
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5i2n B Reference
       Region 5i2n B 394-490 order
       Region 5i2n B 491-493 disorder
       Region 5i2n B 494-544 order
       Region 5i2n B 663-794 order
       Region 5i2n B 795-800 disorder
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5h8f B Reference
       Region 5h8f B 394-396 disorder
       Region 5h8f B 397-490 order
       Region 5h8f B 491-493 disorder
       Region 5h8f B 494-544 order
       Region 5h8f B 663-798 order
       Region 5h8f B 799-800 disorder
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5i2k B Reference
       Region 5i2k B 394-490 order
       Region 5i2k B 491-493 disorder
       Region 5i2k B 494-544 order
       Region 5i2k B 663-798 order
       Region 5i2k B 799-800 disorder
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5h8h B Reference
       Region 5h8h B 394-490 order
       Region 5h8h B 491-493 disorder
       Region 5h8h B 494-544 order
       Region 5h8h B 663-794 order
       Region 5h8h B 795-800 disorder
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5tpa B Reference
       Region 5tpa B 394-425 order
       Region 5tpa B 426-428 disorder
       Region 5tpa B 429-490 order
       Region 5tpa B 491-494 disorder
       Region 5tpa B 495-544 order
       Region 5tpa B 663-794 order
       Region 5tpa B 795-797 disorder
       Region 5tpa B 798-798 order
       Region 5tpa B 799-800 disorder
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5kcj B Reference
       Region 5kcj B 394-395 disorder
       Region 5kcj B 396-490 order
       Region 5kcj B 491-493 disorder
       Region 5kcj B 494-544 order
       Region 5kcj B 663-794 order
       Region 5kcj B 795-800 disorder
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5h8q B Reference
       Region 5h8q B 394-395 disorder
       Region 5h8q B 396-490 order
       Region 5h8q B 491-493 disorder
       Region 5h8q B 494-544 order
       Region 5h8q B 663-795 order
       Region 5h8q B 796-800 disorder
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5h8n B Reference
       Region 5h8n B 394-395 disorder
       Region 5h8n B 396-490 order
       Region 5h8n B 491-493 disorder
       Region 5h8n B 494-544 order
       Region 5h8n B 663-796 order
       Region 5h8n B 797-800 disorder
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5kdt B Reference
       Region 5kdt B 394-490 order
       Region 5kdt B 491-493 disorder
       Region 5kdt B 494-544 order
       Region 5kdt B 663-796 order
       Region 5kdt B 797-800 disorder
Seq 394-544,663-800 Hetero tetramer : IID00664Complex
 Evidence X-RAY 5tp9 B Reference
       Region 5tp9 B 394-490 order
       Region 5tp9 B 491-493 disorder
       Region 5tp9 B 494-544 order
       Region 5tp9 B 663-796 order
       Region 5tp9 B 797-800 disorder
Seq 599-621 Monomer :
 Evidence NMR 2nr1 A Reference
       Region 2nr1 A 599-621 order
Seq 875-898 Hetero dimer : IID00706Complex
 Evidence X-RAY 3bya B Reference
       Region 3bya B 875-894 order
       Region 3bya B 895-898 disorder
Seq 875-898 Hetero dimer : P0DP29
 Evidence X-RAY 2hqw B Reference
       Region 2hqw B 875-896 order
       Region 2hqw B 897-898 disorder
SeqProS predicted 875-896 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : P0DP29
       Region 2hqw B 875-896 order
Seqphosphorylation
    897-897 Phosphoserine; by PKC
    896-896 Phosphoserine; by PKC
    890-890 Phosphoserine; by PKC
    889-889 Phosphoserine; by PKC
 
Prediction
NeProc
Disorder 1-22,839-938
Order 23-97,105-838
ProS 1-16,839-866,888-897,907-938
AlphaFold
Disorder 1-23,54-56,98-101,188-191,441-448,547-549,551-551,585-601,621-621,658-660,662-662,800-809,862-938
Order 24-53,57-97,102-187,192-440,449-546,550-550,552-584,602-620,622-657,661-661,663-799,810-861
Function
Function in SwissProt
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).