Search Keyword:


Search option:


IID00970
 UniprotQ07820
ProteinInduced myeloid leukemia cell differentiation protein Mcl-1
GeneMCL1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
350
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 73-88 Hetero dimer : Q9H2K2
 Evidence X-RAY 3twu B Reference
       Region 3twu B 73-75 disorder
       Region 3twu B 76-88 order
Seq 163-326 Hetero dimer : IID00951Complex
 Evidence NMR 2kbw A Reference
       Region 2kbw A 163-166 disorder
       Region 2kbw A 167-326 order
       Region 2kbw A 167-170 high_rmsd
       Region 2kbw A 200-200 high_rmsd
       Region 2kbw A 322-326 high_rmsd
Seq 171-323 Homo tetramer :
 Evidence X-RAY 6u63 A Reference
       Region 6u63 A 171-171 disorder
       Region 6u63 A 172-196 order
       Region 6u63 A 197-200 disorder
       Region 6u63 A 201-321 order
       Region 6u63 A 322-323 disorder
 Evidence X-RAY 6u63 B Reference
       Region 6u63 B 171-171 disorder
       Region 6u63 B 172-192 order
       Region 6u63 B 193-201 disorder
       Region 6u63 B 202-321 order
       Region 6u63 B 322-323 disorder
 Evidence X-RAY 6u63 C Reference
       Region 6u63 C 171-193 order
       Region 6u63 C 194-202 disorder
       Region 6u63 C 203-237 order
       Region 6u63 C 238-240 disorder
       Region 6u63 C 241-320 order
       Region 6u63 C 321-323 disorder
 Evidence X-RAY 6u63 D Reference
       Region 6u63 D 171-171 disorder
       Region 6u63 D 172-197 order
       Region 6u63 D 198-201 disorder
       Region 6u63 D 202-320 order
       Region 6u63 D 321-323 disorder
Seq 171-323 Homo trimer :
 Evidence X-RAY 6u6f A Reference
       Region 6u6f A 171-321 order
       Region 6u6f A 322-323 disorder
 Evidence X-RAY 6u6f B Reference
       Region 6u6f B 171-321 order
       Region 6u6f B 322-323 disorder
 Evidence X-RAY 6u6f C Reference
       Region 6u6f C 171-171 disorder
       Region 6u6f C 172-322 order
       Region 6u6f C 323-323 disorder
Seq 171-327 Monomer :
 Evidence NMR 2mhs A Reference
       Region 2mhs A 171-327 order
       Region 2mhs A 326-327 high_rmsd
 Evidence X-RAY 3wix A Reference
       Region 3wix A 172-321 order
       Region 3wix A 322-327 disorder
 Evidence X-RAY 3wix B Reference
       Region 3wix B 172-321 order
       Region 3wix B 322-327 disorder
 Evidence X-RAY 3wix C Reference
       Region 3wix C 172-196 order
       Region 3wix C 197-202 disorder
       Region 3wix C 203-321 order
       Region 3wix C 322-327 disorder
 Evidence X-RAY 3wix D Reference
       Region 3wix D 172-195 order
       Region 3wix D 196-202 disorder
       Region 3wix D 203-321 order
       Region 3wix D 322-327 disorder
 Evidence X-RAY 3wiy A Reference
       Region 3wiy A 172-323 order
       Region 3wiy A 324-327 disorder
 Evidence X-RAY 3wiy B Reference
       Region 3wiy B 172-322 order
       Region 3wiy B 323-327 disorder
 Evidence X-RAY 3wiy C Reference
       Region 3wiy C 172-321 order
       Region 3wiy C 322-327 disorder
 Evidence X-RAY 3wiy D Reference
       Region 3wiy D 172-321 order
       Region 3wiy D 322-327 disorder
 Evidence X-RAY 3wiy E Reference
       Region 3wiy E 172-323 order
       Region 3wiy E 324-327 disorder
 Evidence X-RAY 3wiy F Reference
       Region 3wiy F 172-321 order
       Region 3wiy F 322-327 disorder
 Evidence X-RAY 4hw2 A Reference
       Region 4hw2 A 172-199 order
       Region 4hw2 A 200-201 disorder
       Region 4hw2 A 202-321 order
       Region 4hw2 A 322-323 disorder
 Evidence X-RAY 4hw2 B Reference
       Region 4hw2 B 172-321 order
       Region 4hw2 B 322-323 disorder
 Evidence X-RAY 4hw2 C Reference
       Region 4hw2 C 172-320 order
       Region 4hw2 C 321-323 disorder
 Evidence X-RAY 4hw2 D Reference
       Region 4hw2 D 172-321 order
       Region 4hw2 D 322-323 disorder
 Evidence X-RAY 4hw2 E Reference
       Region 4hw2 E 172-321 order
       Region 4hw2 E 322-323 disorder
 Evidence X-RAY 4hw2 F Reference
       Region 4hw2 F 172-320 order
       Region 4hw2 F 321-323 disorder
 Evidence X-RAY 4hw3 A Reference
       Region 4hw3 A 172-320 order
       Region 4hw3 A 321-323 disorder
 Evidence X-RAY 4hw3 J Reference
       Region 4hw3 J 172-321 order
       Region 4hw3 J 322-323 disorder
 Evidence X-RAY 4hw3 K Reference
       Region 4hw3 K 172-321 order
       Region 4hw3 K 322-323 disorder
 Evidence X-RAY 4hw3 L Reference
       Region 4hw3 L 172-192 order
       Region 4hw3 L 193-196 disorder
       Region 4hw3 L 197-323 order
 Evidence X-RAY 4hw3 B Reference
       Region 4hw3 B 172-321 order
       Region 4hw3 B 322-323 disorder
 Evidence X-RAY 4hw3 C Reference
       Region 4hw3 C 172-320 order
       Region 4hw3 C 321-323 disorder
 Evidence X-RAY 4hw3 D Reference
       Region 4hw3 D 172-323 order
 Evidence X-RAY 4hw3 E Reference
       Region 4hw3 E 172-321 order
       Region 4hw3 E 322-323 disorder
 Evidence X-RAY 4hw3 F Reference
       Region 4hw3 F 172-321 order
       Region 4hw3 F 322-323 disorder
 Evidence X-RAY 4hw3 G Reference
       Region 4hw3 G 172-321 order
       Region 4hw3 G 322-323 disorder
 Evidence X-RAY 4hw3 H Reference
       Region 4hw3 H 172-320 order
       Region 4hw3 H 321-323 disorder
 Evidence X-RAY 4hw3 I Reference
       Region 4hw3 I 172-198 order
       Region 4hw3 I 199-201 disorder
       Region 4hw3 I 202-320 order
       Region 4hw3 I 321-323 disorder
 Evidence X-RAY 4oq5 A Reference
       Region 4oq5 A 174-263 order
       Region 4oq5 A 264-264 disorder
       Region 4oq5 A 265-322 order
       Region 4oq5 A 323-326 disorder
 Evidence X-RAY 4oq5 B Reference
       Region 4oq5 B 174-322 order
       Region 4oq5 B 323-326 disorder
 Evidence X-RAY 4oq5 C Reference
       Region 4oq5 C 174-320 order
       Region 4oq5 C 321-326 disorder
 Evidence X-RAY 4oq5 D Reference
       Region 4oq5 D 174-320 order
       Region 4oq5 D 321-326 disorder
 Evidence X-RAY 4oq5 E Reference
       Region 4oq5 E 174-322 order
       Region 4oq5 E 323-326 disorder
 Evidence X-RAY 4oq5 F Reference
       Region 4oq5 F 174-320 order
       Region 4oq5 F 321-326 disorder
 Evidence X-RAY 4oq6 A Reference
       Region 4oq6 A 174-194 order
       Region 4oq6 A 195-201 disorder
       Region 4oq6 A 202-320 order
       Region 4oq6 A 321-326 disorder
 Evidence X-RAY 4oq6 B Reference
       Region 4oq6 B 174-194 order
       Region 4oq6 B 195-202 disorder
       Region 4oq6 B 203-321 order
       Region 4oq6 B 322-326 disorder
 Evidence X-RAY 4wmr A Reference
       Region 4wmr A 173-321 order
 Evidence X-RAY 4zbf A Reference
       Region 4zbf A 172-323 order
       Region 4zbf A 324-327 disorder
 Evidence X-RAY 4zbf I Reference
       Region 4zbf I 172-321 order
       Region 4zbf I 322-327 disorder
 Evidence X-RAY 4zbf J Reference
       Region 4zbf J 172-321 order
       Region 4zbf J 322-327 disorder
 Evidence X-RAY 4zbf K Reference
       Region 4zbf K 172-321 order
       Region 4zbf K 322-327 disorder
 Evidence X-RAY 4zbf L Reference
       Region 4zbf L 172-321 order
       Region 4zbf L 322-327 disorder
 Evidence X-RAY 4zbf B Reference
       Region 4zbf B 172-321 order
       Region 4zbf B 322-327 disorder
 Evidence X-RAY 4zbf C Reference
       Region 4zbf C 172-199 order
       Region 4zbf C 200-202 disorder
       Region 4zbf C 203-322 order
       Region 4zbf C 323-327 disorder
 Evidence X-RAY 4zbf D Reference
       Region 4zbf D 172-199 order
       Region 4zbf D 200-202 disorder
       Region 4zbf D 203-321 order
       Region 4zbf D 322-327 disorder
 Evidence X-RAY 4zbf E Reference
       Region 4zbf E 172-321 order
       Region 4zbf E 322-327 disorder
 Evidence X-RAY 4zbf F Reference
       Region 4zbf F 172-199 order
       Region 4zbf F 200-202 disorder
       Region 4zbf F 203-321 order
       Region 4zbf F 322-327 disorder
 Evidence X-RAY 4zbf G Reference
       Region 4zbf G 172-321 order
       Region 4zbf G 322-327 disorder
 Evidence X-RAY 4zbf H Reference
       Region 4zbf H 172-321 order
       Region 4zbf H 322-327 disorder
 Evidence X-RAY 4zbi A Reference
       Region 4zbi A 172-322 order
       Region 4zbi A 323-327 disorder
 Evidence X-RAY 4zbi J Reference
       Region 4zbi J 172-322 order
       Region 4zbi J 323-327 disorder
 Evidence X-RAY 4zbi K Reference
       Region 4zbi K 172-320 order
       Region 4zbi K 321-327 disorder
 Evidence X-RAY 4zbi L Reference
       Region 4zbi L 172-321 order
       Region 4zbi L 322-327 disorder
 Evidence X-RAY 4zbi B Reference
       Region 4zbi B 172-323 order
       Region 4zbi B 324-327 disorder
 Evidence X-RAY 4zbi C Reference
       Region 4zbi C 172-321 order
       Region 4zbi C 322-327 disorder
 Evidence X-RAY 4zbi D Reference
       Region 4zbi D 172-322 order
       Region 4zbi D 323-327 disorder
 Evidence X-RAY 4zbi E Reference
       Region 4zbi E 172-322 order
       Region 4zbi E 323-327 disorder
 Evidence X-RAY 4zbi F Reference
       Region 4zbi F 172-321 order
       Region 4zbi F 322-327 disorder
 Evidence X-RAY 4zbi G Reference
       Region 4zbi G 172-322 order
       Region 4zbi G 323-327 disorder
 Evidence X-RAY 4zbi H Reference
       Region 4zbi H 172-321 order
       Region 4zbi H 322-327 disorder
 Evidence X-RAY 4zbi I Reference
       Region 4zbi I 172-321 order
       Region 4zbi I 322-327 disorder
 Evidence X-RAY 5fc4 A Reference
       Region 5fc4 A 172-191 order
       Region 5fc4 A 192-201 disorder
       Region 5fc4 A 202-320 order
 Evidence X-RAY 5fdo A Reference
       Region 5fdo A 172-194 order
       Region 5fdo A 195-202 disorder
       Region 5fdo A 203-320 order
 Evidence X-RAY 5fdo B Reference
       Region 5fdo B 172-320 order
 Evidence X-RAY 5fdo C Reference
       Region 5fdo C 172-195 order
       Region 5fdo C 196-202 disorder
       Region 5fdo C 203-320 order
 Evidence X-RAY 5fdo D Reference
       Region 5fdo D 172-191 order
       Region 5fdo D 192-202 disorder
       Region 5fdo D 203-255 order
       Region 5fdo D 256-257 disorder
       Region 5fdo D 258-320 order
 Evidence X-RAY 5fdr A Reference
       Region 5fdr A 172-325 order
       Region 5fdr A 326-327 disorder
 Evidence X-RAY 5fdr B Reference
       Region 5fdr B 172-196 order
       Region 5fdr B 197-198 disorder
       Region 5fdr B 199-321 order
       Region 5fdr B 322-327 disorder
 Evidence X-RAY 5fdr C Reference
       Region 5fdr C 172-192 order
       Region 5fdr C 193-202 disorder
       Region 5fdr C 203-324 order
       Region 5fdr C 325-327 disorder
 Evidence X-RAY 5fdr D Reference
       Region 5fdr D 172-196 order
       Region 5fdr D 197-198 disorder
       Region 5fdr D 199-321 order
       Region 5fdr D 322-327 disorder
 Evidence X-RAY 5iez A Reference
       Region 5iez A 172-321 order
       Region 5iez A 322-327 disorder
 Evidence X-RAY 5iez B Reference
       Region 5iez B 172-323 order
       Region 5iez B 324-327 disorder
 Evidence X-RAY 5iez C Reference
       Region 5iez C 172-323 order
       Region 5iez C 324-327 disorder
 Evidence X-RAY 5iez D Reference
       Region 5iez D 172-195 order
       Region 5iez D 196-202 disorder
       Region 5iez D 203-323 order
       Region 5iez D 324-327 disorder
 Evidence X-RAY 5if4 A Reference
       Region 5if4 A 172-322 order
       Region 5if4 A 323-327 disorder
 Evidence X-RAY 5if4 B Reference
       Region 5if4 B 172-324 order
       Region 5if4 B 325-327 disorder
 Evidence X-RAY 5w89 A Reference
       Region 5w89 A 172-191 order
       Region 5w89 A 192-201 disorder
       Region 5w89 A 202-321 order
 Evidence X-RAY 6b4l A Reference
       Region 6b4l A 174-320 order
       Region 6b4l A 321-326 disorder
 Evidence X-RAY 6b4l B Reference
       Region 6b4l B 174-320 order
       Region 6b4l B 321-326 disorder
 Evidence X-RAY 6b4u A Reference
       Region 6b4u A 174-325 order
       Region 6b4u A 326-326 disorder
 Evidence X-RAY 6bw2 A Reference
       Region 6bw2 A 172-321 order
       Region 6bw2 A 322-327 disorder
 Evidence X-RAY 6bw2 B Reference
       Region 6bw2 B 172-172 disorder
       Region 6bw2 B 173-320 order
       Region 6bw2 B 321-327 disorder
 Evidence X-RAY 6bw2 C Reference
       Region 6bw2 C 172-320 order
       Region 6bw2 C 321-327 disorder
 Evidence X-RAY 6bw2 D Reference
       Region 6bw2 D 172-172 disorder
       Region 6bw2 D 173-320 order
       Region 6bw2 D 321-327 disorder
 Evidence X-RAY 6bw8 A Reference
       Region 6bw8 A 172-320 order
       Region 6bw8 A 321-327 disorder
 Evidence X-RAY 6bw8 B Reference
       Region 6bw8 B 172-195 order
       Region 6bw8 B 196-197 disorder
       Region 6bw8 B 198-321 order
       Region 6bw8 B 322-327 disorder
 Evidence X-RAY 6bw8 C Reference
       Region 6bw8 C 172-194 order
       Region 6bw8 C 195-196 disorder
       Region 6bw8 C 197-201 order
       Region 6bw8 C 202-203 disorder
       Region 6bw8 C 204-275 order
       Region 6bw8 C 276-276 disorder
       Region 6bw8 C 277-320 order
       Region 6bw8 C 321-327 disorder
 Evidence X-RAY 6bw8 D Reference
       Region 6bw8 D 172-320 order
       Region 6bw8 D 321-327 disorder
 Evidence X-RAY 6o6g A Reference
       Region 6o6g A 172-195 order
       Region 6o6g A 196-200 disorder
       Region 6o6g A 201-321 order
       Region 6o6g A 322-327 disorder
 Evidence X-RAY 6oqb A Reference
       Region 6oqb A 171-171 disorder
       Region 6oqb A 172-326 order
       Region 6oqb A 327-327 disorder
 Evidence X-RAY 6oqd A Reference
       Region 6oqd A 171-326 order
       Region 6oqd A 327-327 disorder
 Evidence NMR 6ovc A Reference
       Region 6ovc A 171-327 order
 Evidence X-RAY 6p3p A Reference
       Region 6p3p A 172-320 order
       Region 6p3p A 321-327 disorder
 Evidence X-RAY 6qfq A Reference
       Region 6qfq A 171-171 disorder
       Region 6qfq A 172-321 order
       Region 6qfq A 322-327 disorder
 Evidence X-RAY 6qyp A Reference
       Region 6qyp A 171-320 order
       Region 6qyp A 321-327 disorder
 Evidence X-RAY 6qz5 A Reference
       Region 6qz5 A 171-320 order
       Region 6qz5 A 321-327 disorder
 Evidence X-RAY 6qz6 A Reference
       Region 6qz6 A 171-320 order
       Region 6qz6 A 321-327 disorder
 Evidence X-RAY 6qz8 A Reference
       Region 6qz8 A 171-322 order
       Region 6qz8 A 323-327 disorder
 Evidence X-RAY 6qzb A Reference
       Region 6qzb A 171-320 order
       Region 6qzb A 321-327 disorder
 Evidence X-RAY 6u64 A Reference
       Region 6u64 A 171-171 disorder
       Region 6u64 A 172-196 order
       Region 6u64 A 197-202 disorder
       Region 6u64 A 203-320 order
 Evidence X-RAY 6ud2 A Reference
       Region 6ud2 A 171-171 disorder
       Region 6ud2 A 172-326 order
       Region 6ud2 A 327-327 disorder
 Evidence X-RAY 6udi A Reference
       Region 6udi A 171-171 disorder
       Region 6udi A 172-326 order
       Region 6udi A 327-327 disorder
 Evidence X-RAY 6udt A Reference
       Region 6udt A 171-171 disorder
       Region 6udt A 172-326 order
       Region 6udt A 327-327 disorder
 Evidence X-RAY 6udu A Reference
       Region 6udu A 171-326 order
       Region 6udu A 327-327 disorder
 Evidence X-RAY 6udv A Reference
       Region 6udv A 171-171 disorder
       Region 6udv A 172-326 order
       Region 6udv A 327-327 disorder
 Evidence X-RAY 7nb4 A Reference
       Region 7nb4 A 171-320 order
       Region 7nb4 A 321-327 disorder
 Evidence X-RAY 8g3s A Reference
       Region 8g3s A 173-321 order
 Evidence X-RAY 8g3t A Reference
       Region 8g3t A 173-321 order
 Evidence X-RAY 8g3u A Reference
       Region 8g3u A 173-321 order
 Evidence X-RAY 8g3w A Reference
       Region 8g3w A 173-321 order
 Evidence X-RAY 8g3x A Reference
       Region 8g3x A 173-321 order
 Evidence X-RAY 8g3y A Reference
       Region 8g3y A 173-321 order
 Evidence X-RAY 8svy A Reference
       Region 8svy A 173-321 order
Seq 171-327 Hetero 24mer : Q7Z6Z7
 Evidence X-RAY 5c6h A Reference
       Region 5c6h A 171-325 order
       Region 5c6h A 326-327 disorder
 Evidence X-RAY 5c6h C Reference
       Region 5c6h C 171-325 order
       Region 5c6h C 326-327 disorder
 Evidence X-RAY 5c6h E Reference
       Region 5c6h E 171-324 order
       Region 5c6h E 325-327 disorder
 Evidence X-RAY 5c6h G Reference
       Region 5c6h G 171-324 order
       Region 5c6h G 325-327 disorder
 Evidence X-RAY 5c6h I Reference
       Region 5c6h I 171-325 order
       Region 5c6h I 326-327 disorder
 Evidence X-RAY 5c6h K Reference
       Region 5c6h K 171-323 order
       Region 5c6h K 324-327 disorder
 Evidence X-RAY 5c6h M Reference
       Region 5c6h M 171-325 order
       Region 5c6h M 326-327 disorder
 Evidence X-RAY 5c6h O Reference
       Region 5c6h O 171-325 order
       Region 5c6h O 326-327 disorder
 Evidence X-RAY 5c6h Q Reference
       Region 5c6h Q 171-324 order
       Region 5c6h Q 325-327 disorder
 Evidence X-RAY 5c6h S Reference
       Region 5c6h S 171-324 order
       Region 5c6h S 325-327 disorder
 Evidence X-RAY 5c6h U Reference
       Region 5c6h U 171-321 order
       Region 5c6h U 322-327 disorder
 Evidence X-RAY 5c6h W Reference
       Region 5c6h W 171-323 order
       Region 5c6h W 324-327 disorder
Seq 171-327 Hetero dimer : H0WYH6
 Evidence X-RAY 8iqm A Reference
       Region 8iqm A 171-197 order
       Region 8iqm A 198-201 disorder
       Region 8iqm A 202-321 order
       Region 8iqm A 322-327 disorder
Seq 171-327 Hetero dimer : IID00746Complex
 Evidence X-RAY 3kj0 A Reference
       Region 3kj0 A 172-326 order
       Region 3kj0 A 327-327 disorder
 Evidence X-RAY 3kj1 A Reference
       Region 3kj1 A 172-322 order
       Region 3kj1 A 323-327 disorder
 Evidence X-RAY 3kj2 A Reference
       Region 3kj2 A 172-322 order
       Region 3kj2 A 323-327 disorder
 Evidence X-RAY 6qfi A Reference
       Region 6qfi A 171-171 disorder
       Region 6qfi A 172-197 order
       Region 6qfi A 198-201 disorder
       Region 6qfi A 202-322 order
       Region 6qfi A 323-327 disorder
 Evidence X-RAY 6ua3 A Reference
       Region 6ua3 A 172-325 order
 Evidence X-RAY 6uab A Reference
       Region 6uab A 172-325 order
Seq 171-327 Homo dimer :
 Evidence X-RAY 5vkc A Reference
       Region 5vkc A 174-194 order
       Region 5vkc A 195-201 disorder
       Region 5vkc A 202-322 order
       Region 5vkc A 323-326 disorder
 Evidence X-RAY 5vkc B Reference
       Region 5vkc B 174-194 order
       Region 5vkc B 195-201 disorder
       Region 5vkc B 202-322 order
       Region 5vkc B 323-326 disorder
 Evidence X-RAY 6fs1 A Reference
       Region 6fs1 A 174-321 order
 Evidence X-RAY 6fs1 B Reference
       Region 6fs1 B 174-321 order
 Evidence X-RAY 6fs2 A Reference
       Region 6fs2 A 174-195 order
       Region 6fs2 A 196-197 disorder
       Region 6fs2 A 198-325 order
 Evidence X-RAY 6fs2 B Reference
       Region 6fs2 B 174-195 order
       Region 6fs2 B 196-197 disorder
       Region 6fs2 B 198-324 order
 Evidence X-RAY 6o4u A Reference
       Region 6o4u A 172-195 order
       Region 6o4u A 196-199 disorder
       Region 6o4u A 200-321 order
       Region 6o4u A 322-327 disorder
 Evidence X-RAY 6o4u B Reference
       Region 6o4u B 172-321 order
       Region 6o4u B 322-327 disorder
 Evidence X-RAY 6o6f A Reference
       Region 6o6f A 172-321 order
       Region 6o6f A 322-327 disorder
 Evidence X-RAY 6o6f B Reference
       Region 6o6f B 172-200 order
       Region 6o6f B 201-201 disorder
       Region 6o6f B 202-321 order
       Region 6o6f B 322-327 disorder
 Evidence X-RAY 6oqc A Reference
       Region 6oqc A 171-322 order
       Region 6oqc A 323-327 disorder
 Evidence X-RAY 6oqc B Reference
       Region 6oqc B 171-171 disorder
       Region 6oqc B 172-322 order
       Region 6oqc B 323-327 disorder
 Evidence X-RAY 6oqn A Reference
       Region 6oqn A 171-321 order
       Region 6oqn A 322-327 disorder
 Evidence X-RAY 6oqn B Reference
       Region 6oqn B 171-321 order
       Region 6oqn B 322-327 disorder
 Evidence X-RAY 6u67 A Reference
       Region 6u67 A 171-171 disorder
       Region 6u67 A 172-321 order
       Region 6u67 A 322-323 disorder
 Evidence X-RAY 6u67 B Reference
       Region 6u67 B 171-321 order
       Region 6u67 B 322-323 disorder
 Evidence X-RAY 6udx A Reference
       Region 6udx A 171-321 order
       Region 6udx A 322-327 disorder
 Evidence X-RAY 6udx B Reference
       Region 6udx B 171-200 order
       Region 6udx B 201-202 disorder
       Region 6udx B 203-321 order
       Region 6udx B 322-327 disorder
 Evidence X-RAY 6udy A Reference
       Region 6udy A 171-321 order
       Region 6udy A 322-327 disorder
 Evidence X-RAY 6udy B Reference
       Region 6udy B 171-200 order
       Region 6udy B 201-201 disorder
       Region 6udy B 202-321 order
       Region 6udy B 322-327 disorder
 Evidence X-RAY 6ybg A Reference
       Region 6ybg A 171-171 disorder
       Region 6ybg A 172-195 order
       Region 6ybg A 196-201 disorder
       Region 6ybg A 202-320 order
       Region 6ybg A 321-327 disorder
 Evidence X-RAY 6ybg B Reference
       Region 6ybg B 171-171 disorder
       Region 6ybg B 172-195 order
       Region 6ybg B 196-202 disorder
       Region 6ybg B 203-322 order
       Region 6ybg B 323-327 disorder
 Evidence X-RAY 8h7b A Reference
       Region 8h7b A 172-201 order
       Region 8h7b A 202-202 disorder
       Region 8h7b A 203-321 order
       Region 8h7b A 322-322 disorder
 Evidence X-RAY 8h7b B Reference
       Region 8h7b B 172-195 order
       Region 8h7b B 196-202 disorder
       Region 8h7b B 203-321 order
       Region 8h7b B 322-322 disorder
Seq 171-327 Hetero dimer : IID01012Complex
 Evidence X-RAY 6qfm A Reference
       Region 6qfm A 171-193 order
       Region 6qfm A 194-203 disorder
       Region 6qfm A 204-320 order
       Region 6qfm A 321-327 disorder
Seq 171-328 Homo tetramer :
 Evidence X-RAY 6ne5 A Reference
       Region 6ne5 A 172-322 order
       Region 6ne5 A 323-328 disorder
 Evidence X-RAY 6ne5 B Reference
       Region 6ne5 B 172-322 order
       Region 6ne5 B 323-328 disorder
 Evidence X-RAY 6ne5 C Reference
       Region 6ne5 C 172-321 order
       Region 6ne5 C 322-328 disorder
 Evidence X-RAY 6ne5 D Reference
       Region 6ne5 D 172-199 order
       Region 6ne5 D 200-201 disorder
       Region 6ne5 D 202-321 order
       Region 6ne5 D 322-328 disorder
 Evidence X-RAY 6u65 A Reference
       Region 6u65 A 171-171 disorder
       Region 6u65 A 172-321 order
       Region 6u65 A 322-323 disorder
 Evidence X-RAY 6u65 B Reference
       Region 6u65 B 171-171 disorder
       Region 6u65 B 172-321 order
       Region 6u65 B 322-323 disorder
 Evidence X-RAY 6u65 C Reference
       Region 6u65 C 171-322 order
       Region 6u65 C 323-323 disorder
 Evidence X-RAY 6u65 D Reference
       Region 6u65 D 171-171 disorder
       Region 6u65 D 172-321 order
       Region 6u65 D 322-323 disorder
 Evidence X-RAY 7nb7 A Reference
       Region 7nb7 A 171-320 order
       Region 7nb7 A 321-327 disorder
 Evidence X-RAY 7nb7 B Reference
       Region 7nb7 B 171-320 order
       Region 7nb7 B 321-327 disorder
 Evidence X-RAY 7nb7 C Reference
       Region 7nb7 C 171-320 order
       Region 7nb7 C 321-327 disorder
 Evidence X-RAY 7nb7 D Reference
       Region 7nb7 D 171-320 order
       Region 7nb7 D 321-327 disorder
Seq 172-320 Hetero dimer :
 Evidence X-RAY 5w8f A Reference
       Region 5w8f A 172-320 order
Seq 172-321 Hetero octamer :
 Evidence X-RAY 7xge B Reference
       Region 7xge B 172-321 order
 Evidence X-RAY 7xge D Reference
       Region 7xge D 172-195 order
       Region 7xge D 196-202 disorder
       Region 7xge D 203-321 order
 Evidence X-RAY 7xge F Reference
       Region 7xge F 172-193 order
       Region 7xge F 194-202 disorder
       Region 7xge F 203-321 order
 Evidence X-RAY 7xge H Reference
       Region 7xge H 172-193 order
       Region 7xge H 194-203 disorder
       Region 7xge H 204-320 order
       Region 7xge H 321-321 disorder
Seq 172-323 Hetero dimer : IID00746Complex
 Evidence X-RAY 6vbx A Reference
       Region 6vbx A 172-172 disorder
       Region 6vbx A 173-193 order
       Region 6vbx A 194-202 disorder
       Region 6vbx A 203-321 order
       Region 6vbx A 322-323 disorder
Seq 172-323 Hetero dimer :
 Evidence X-RAY 6mbe A Reference
       Region 6mbe A 172-323 order
Seq 172-324 Hetero tetramer :
 Evidence X-RAY 6mbd A Reference
       Region 6mbd A 172-324 order
 Evidence X-RAY 6mbd B Reference
       Region 6mbd B 172-323 order
       Region 6mbd B 324-324 disorder
Seq 172-325 Hetero tetramer :
 Evidence X-RAY 5uum A Reference
       Region 5uum A 172-325 order
 Evidence X-RAY 5uum B Reference
       Region 5uum B 172-325 order
Seq 172-327 Hetero dimer :
 Evidence X-RAY 3mk8 A Reference
       Region 3mk8 A 172-193 order
       Region 3mk8 A 194-201 disorder
       Region 3mk8 A 202-320 order
       Region 3mk8 A 321-327 disorder
 Evidence X-RAY 3mk8 B Reference
       Region 3mk8 B 208-208 disorder
       Region 3mk8 B 209-227 order
       Region 3mk8 B 228-228 disorder
Seq 172-327 Hetero dimer :
 Evidence X-RAY 3kz0 B Reference
       Region 3kz0 B 172-195 order
       Region 3kz0 B 196-200 disorder
       Region 3kz0 B 201-321 order
       Region 3kz0 B 322-327 disorder
Seq 172-327 Hetero dimer :
 Evidence X-RAY 4hw4 A Reference
       Region 4hw4 A 172-324 order
       Region 4hw4 A 325-327 disorder
Seq 172-327 Hetero dimer :
 Evidence X-RAY 4hw4 B Reference
       Region 4hw4 B 172-192 order
       Region 4hw4 B 193-202 disorder
       Region 4hw4 B 203-321 order
       Region 4hw4 B 322-327 disorder
Seq 172-327 Hetero dimer :
 Evidence X-RAY 2pqk A Reference
       Region 2pqk A 172-197 order
       Region 2pqk A 198-202 disorder
       Region 2pqk A 203-321 order
       Region 2pqk A 322-327 disorder
Seq 172-327 Hetero dimer :
 Evidence X-RAY 3kz0 A Reference
       Region 3kz0 A 172-195 order
       Region 3kz0 A 196-202 disorder
       Region 3kz0 A 203-321 order
       Region 3kz0 A 322-327 disorder
Seq 172-327 Hetero dimer :
 Evidence X-RAY 6zie B Reference
       Region 6zie B 172-199 order
       Region 6zie B 200-201 disorder
       Region 6zie B 202-322 order
       Region 6zie B 323-327 disorder
Seq 172-350 Hetero dimer :
 Evidence X-RAY 5jsb G Reference
       Region 5jsb G 172-322 order
       Region 5jsb G 323-350 disorder
Seq 172-350 Hetero dimer :
 Evidence X-RAY 5jsb K Reference
       Region 5jsb K 172-322 order
       Region 5jsb K 323-350 disorder
Seq 172-350 Hetero dimer :
 Evidence X-RAY 5jsb A Reference
       Region 5jsb A 172-322 order
       Region 5jsb A 323-350 disorder
Seq 172-350 Hetero dimer :
 Evidence X-RAY 5jsb C Reference
       Region 5jsb C 172-322 order
       Region 5jsb C 323-350 disorder
Seq 172-350 Hetero dimer :
 Evidence X-RAY 5jsb I Reference
       Region 5jsb I 172-322 order
       Region 5jsb I 323-350 disorder
Seq 172-350 Hetero dimer :
 Evidence X-RAY 5jsb E Reference
       Region 5jsb E 172-322 order
       Region 5jsb E 323-350 disorder
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6ybj A Reference
       Region 6ybj A 173-321 order
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6qxj A Reference
       Region 6qxj A 173-320 order
       Region 6qxj A 321-321 disorder
Seq 173-321 Hetero dimer : P0AEY0
 Evidence X-RAY 4wgi A Reference
       Region 4wgi A 173-201 order
       Region 4wgi A 202-202 disorder
       Region 4wgi A 203-321 order
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 8ekx A Reference
       Region 8ekx A 173-320 order
       Region 8ekx A 321-321 disorder
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6qyk A Reference
       Region 6qyk A 173-320 order
       Region 6qyk A 321-321 disorder
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6qz7 A Reference
       Region 6qz7 A 173-321 order
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6qyn A Reference
       Region 6qyn A 173-321 order
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6qyo A Reference
       Region 6qyo A 173-199 order
       Region 6qyo A 200-201 disorder
       Region 6qyo A 202-321 order
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6qgd A Reference
       Region 6qgd A 173-200 order
       Region 6qgd A 201-202 disorder
       Region 6qgd A 203-321 order
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6qyl A Reference
       Region 6qyl A 173-321 order
Seq 173-321 Hetero dimer : P0AEY0
 Evidence X-RAY 5lof A Reference
       Region 5lof A 173-321 order
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 8el0 A Reference
       Region 8el0 A 173-320 order
       Region 8el0 A 321-321 disorder
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6ybk A Reference
       Region 6ybk A 173-321 order
Seq 173-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 6ybl A Reference
       Region 6ybl A 173-321 order
Seq 173-321 Hetero octamer : IID90020Complex
 Evidence X-RAY 8el1 A Reference
       Region 8el1 A 173-320 order
       Region 8el1 A 321-321 disorder
 Evidence X-RAY 8el1 B Reference
       Region 8el1 B 173-320 order
       Region 8el1 B 321-321 disorder
 Evidence X-RAY 8el1 C Reference
       Region 8el1 C 173-320 order
       Region 8el1 C 321-321 disorder
 Evidence X-RAY 8el1 D Reference
       Region 8el1 D 173-320 order
       Region 8el1 D 321-321 disorder
Seq 173-327 Hetero octamer :
 Evidence X-RAY 6stj A Reference
       Region 6stj A 173-193 order
       Region 6stj A 194-203 disorder
       Region 6stj A 204-322 order
       Region 6stj A 323-327 disorder
 Evidence X-RAY 6stj B Reference
       Region 6stj B 173-194 order
       Region 6stj B 195-203 disorder
       Region 6stj B 204-322 order
       Region 6stj B 323-327 disorder
 Evidence X-RAY 6stj C Reference
       Region 6stj C 173-175 disorder
       Region 6stj C 176-192 order
       Region 6stj C 193-208 disorder
       Region 6stj C 209-232 order
       Region 6stj C 233-258 disorder
       Region 6stj C 259-320 order
       Region 6stj C 321-327 disorder
 Evidence X-RAY 6stj D Reference
       Region 6stj D 173-192 order
       Region 6stj D 193-204 disorder
       Region 6stj D 205-254 order
       Region 6stj D 255-257 disorder
       Region 6stj D 258-320 order
       Region 6stj D 321-327 disorder
Seq 173-327 Hetero dimer : IID00951Complex
 Evidence X-RAY 5c3f A Reference
       Region 5c3f A 173-322 order
       Region 5c3f A 323-327 disorder
Seq 174-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 4wmu A Reference
       Region 4wmu A 174-320 order
       Region 4wmu A 321-321 disorder
Seq 174-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 4wmv A Reference
       Region 4wmv A 174-321 order
Seq 174-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 4wmw A Reference
       Region 4wmw A 174-321 order
Seq 174-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 4wmx A Reference
       Region 4wmx A 174-321 order
Seq 174-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 4wms A Reference
       Region 4wms A 174-253 order
       Region 4wms A 254-256 disorder
       Region 4wms A 257-320 order
       Region 4wms A 321-321 disorder
Seq 174-321 Hetero dimer : IID90020Complex
 Evidence X-RAY 4wmt A Reference
       Region 4wmt A 174-320 order
       Region 4wmt A 321-321 disorder
Seq 174-324 Hetero trimer :
 Evidence X-RAY 6fs0 A Reference
       Region 6fs0 A 174-321 order
       Region 6fs0 A 322-324 disorder
Seq 174-326 Hetero dimer : Q07812
 Evidence X-RAY 3pk1 A Reference
       Region 3pk1 A 174-194 order
       Region 3pk1 A 195-203 disorder
       Region 3pk1 A 204-321 order
       Region 3pk1 A 322-326 disorder
 Evidence X-RAY 3pk1 C Reference
       Region 3pk1 C 174-192 order
       Region 3pk1 C 193-204 disorder
       Region 3pk1 C 205-321 order
       Region 3pk1 C 322-326 disorder
Seq 174-327 Hetero trimer :
 Evidence X-RAY 8av9 A Reference
       Region 8av9 A 174-322 order
       Region 8av9 A 323-327 disorder
Seq 174-327 Hetero dimer :
 Evidence X-RAY 6qfc A Reference
       Region 6qfc A 174-195 order
       Region 6qfc A 196-203 disorder
       Region 6qfc A 204-321 order
       Region 6qfc A 322-327 disorder
Seq 174-327 Hetero dimer :
 Evidence X-RAY 6qb3 A Reference
       Region 6qb3 A 174-195 order
       Region 6qb3 A 196-203 disorder
       Region 6qb3 A 204-321 order
       Region 6qb3 A 322-327 disorder
Seq 174-327 Hetero dimer :
 Evidence X-RAY 6qb4 A Reference
       Region 6qb4 A 174-195 order
       Region 6qb4 A 196-203 disorder
       Region 6qb4 A 204-321 order
       Region 6qb4 A 322-327 disorder
Seq 174-327 Hetero trimer :
 Evidence X-RAY 6qb6 A Reference
       Region 6qb6 A 174-324 order
       Region 6qb6 A 325-327 disorder
Seq 209-327 Hetero tetramer : P97287
 Evidence X-RAY 5mev A Reference
       Region 5mev A 209-322 order
       Region 5mev A 323-327 disorder
Seq 209-327 Hetero trimer : IID00746Complex,P97287
 Evidence X-RAY 3d7v A Reference
       Region 3d7v A 209-322 order
       Region 3d7v A 323-327 disorder
Seq 209-327 Hetero hexamer : IID01012Complex,P97287
 Evidence X-RAY 4bpj A Reference
       Region 4bpj A 209-322 order
       Region 4bpj A 323-327 disorder
Seq 209-327 Hetero trimer : IID00746Complex,P97287
 Evidence X-RAY 2nl9 A Reference
       Region 2nl9 A 209-322 order
       Region 2nl9 A 323-327 disorder
Seq 209-327 Hetero trimer : P97287
 Evidence X-RAY 5ku9 B Reference
       Region 5ku9 B 209-322 order
       Region 5ku9 B 323-327 disorder
Seq 209-327 Hetero hexamer : IID01012Complex,P97287
 Evidence X-RAY 4bpi A Reference
       Region 4bpi A 209-322 order
       Region 4bpi A 323-327 disorder
Seq 209-327 Hetero tetramer : P97287
 Evidence X-RAY 5mes A Reference
       Region 5mes A 209-322 order
       Region 5mes A 323-327 disorder
Seq 209-327 Hetero trimer : IID00746Complex,P97287
 Evidence X-RAY 3io9 A Reference
       Region 3io9 A 209-322 order
       Region 3io9 A 323-327 disorder
Seq 209-327 Hetero hexamer : IID00746Complex,P97287
 Evidence X-RAY 5vx2 A Reference
       Region 5vx2 A 209-322 order
       Region 5vx2 A 323-327 disorder
 Evidence X-RAY 5vx2 C Reference
       Region 5vx2 C 209-321 order
       Region 5vx2 C 322-327 disorder
Seq 209-327 Hetero trimer : P97287
 Evidence X-RAY 5ku9 A Reference
       Region 5ku9 A 209-322 order
       Region 5ku9 A 323-327 disorder
Seq 209-327 Hetero trimer : P97287,Q9JM54
 Evidence X-RAY 2nla A Reference
       Region 2nla A 209-321 order
       Region 2nla A 322-327 disorder
SeqProS possible 76-88 The conformation of the MCL1 peptide in the complex is similar to that of the Arpin peptide in complex with the ARD (PDB: 4Z68); Tankyrases recruit specific motifs; This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : Q9H2K2
       Region 3twu B 76-88 order
Seqphosphorylation
    121-121 Phosphoserine
    159-159 Phosphoserine; by GSK3-alpha and GSK3-beta
    162-162 Phosphoserine
    163-163 Phosphothreonine; by MAPK
 
Prediction
NeProc
Disorder 1-172,197-206,350-350
Order 173-196,207-349
ProS 1-19,66-72,83-90,97-104,116-133,169-172,350-350
AlphaFold
Disorder 1-170,321-350
Order 171-320
SEG 11-33 ,41-64 ,105-118 ,331-346
Function
Function in SwissProt
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.