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IID00971
 UniprotQ13009
ProteinRho guanine nucleotide exchange factor TIAM1
GeneTIAM1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1591
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 429-702 Monomer :
 Evidence X-RAY 4k2o A Reference
       Region 4k2o A 429-431 disorder
       Region 4k2o A 432-481 order
       Region 4k2o A 482-489 disorder
       Region 4k2o A 490-671 order
       Region 4k2o A 672-702 disorder
 Evidence X-RAY 4k2p A Reference
       Region 4k2p A 429-432 disorder
       Region 4k2p A 433-670 order
       Region 4k2p A 671-702 disorder
 Evidence X-RAY 4k2p B Reference
       Region 4k2p B 429-432 disorder
       Region 4k2p B 433-670 order
       Region 4k2p B 671-702 disorder
 Evidence X-RAY 4k2p C Reference
       Region 4k2p C 429-432 disorder
       Region 4k2p C 433-457 order
       Region 4k2p C 458-459 disorder
       Region 4k2p C 460-479 order
       Region 4k2p C 480-481 disorder
       Region 4k2p C 482-485 order
       Region 4k2p C 486-486 disorder
       Region 4k2p C 487-670 order
       Region 4k2p C 671-702 disorder
 Evidence X-RAY 4k2p D Reference
       Region 4k2p D 429-433 disorder
       Region 4k2p D 434-449 order
       Region 4k2p D 450-452 disorder
       Region 4k2p D 453-457 order
       Region 4k2p D 458-459 disorder
       Region 4k2p D 460-670 order
       Region 4k2p D 671-702 disorder
Seq 835-935 Monomer :
 Evidence NMR 2d8i A Reference
       Region 2d8i A 835-935 order
       Region 2d8i A 835-839 high_rmsd
       Region 2d8i A 931-935 high_rmsd
 Evidence X-RAY 3kzd A Reference
       Region 3kzd A 841-850 order
       Region 3kzd A 851-856 disorder
       Region 3kzd A 857-930 order
 Evidence X-RAY 4nxp A Reference
       Region 4nxp A 841-850 order
       Region 4nxp A 851-855 disorder
       Region 4nxp A 856-930 order
Seq 841-930 Hetero dimer : IID00953Complex
 Evidence X-RAY 4nxr A Reference
       Region 4nxr A 841-930 order
Seq 841-930 Hetero pentamer :
 Evidence X-RAY 3kze A Reference
       Region 3kze A 841-930 order
 Evidence X-RAY 3kze B Reference
       Region 3kze B 841-930 order
 Evidence X-RAY 3kze C Reference
       Region 3kze C 841-852 order
       Region 3kze C 853-854 disorder
       Region 3kze C 855-866 order
       Region 3kze C 867-868 disorder
       Region 3kze C 869-929 order
       Region 3kze C 930-930 disorder
Seq 841-930 Hetero dimer : IID00929Complex
 Evidence X-RAY 4gvc A Reference
       Region 4gvc A 841-930 order
 Evidence X-RAY 4gvd A Reference
       Region 4gvd A 841-850 order
       Region 4gvd A 851-854 disorder
       Region 4gvd A 855-867 order
       Region 4gvd A 868-869 disorder
       Region 4gvd A 870-929 order
       Region 4gvd A 930-930 disorder
 Evidence X-RAY 4gvd B Reference
       Region 4gvd B 841-928 order
       Region 4gvd B 929-930 disorder
Seq 841-930 Hetero dimer : IID01015Complex
 Evidence X-RAY 4nxq A Reference
       Region 4nxq A 841-929 order
       Region 4nxq A 930-930 disorder
 Evidence X-RAY 4nxq B Reference
       Region 4nxq B 841-930 order
 Evidence X-RAY 4nxq C Reference
       Region 4nxq C 841-930 order
Seqphosphorylation
    231-231 Phosphoserine
    356-356 Phosphoserine
    358-358 Phosphoserine
    829-829 Phosphotyrosine; by NTRK2
    695-695 Phosphoserine
    1323-1323 Phosphotyrosine
    1519-1519 Phosphoserine
 
Prediction
NeProc
Disorder 1-94,108-424,660-756,925-1035,1308-1323,1400-1591
Order 95-107,425-659,757-924,1036-1307,1324-1399
ProS 1-40,46-53,61-94,108-112,131-157,176-195,208-237,250-269,275-359,374-408,419-424,660-677,694-702,729-735,749-756,925-970,990-1016,1410-1424,1454-1461,1500-1512,1521-1535,1571-1591
AlphaFold
Disorder 1-432,450-451,459-459,479-489,671-765,815-815,851-856,867-868,929-939,943-1034,1253-1255,1283-1283,1285-1285,1307-1326,1344-1351,1403-1591
Order 433-449,452-458,460-478,490-670,766-814,816-850,857-866,869-928,940-942,1035-1252,1256-1282,1284-1284,1286-1306,1327-1343,1352-1402
Pfam Hmmer
765->832 434-547 845->925
SEG 52-67 ,100-115 ,178-189 ,367-377 ,573-586 ,683-695 ,1014-1024 ,1445-1454
Function
Function in SwissProt
Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.