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IID00972
 UniprotQ13137
ProteinCalcium-binding and coiled-coil domain-containing protein 2
GeneCALCOCO2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
446
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-141 Homo dimer :
 Evidence X-RAY 3vvv A Reference
       Region 3vvv A 21-80 order
       Region 3vvv A 81-86 disorder
       Region 3vvv A 87-132 order
       Region 3vvv A 133-141 disorder
 Evidence X-RAY 5z7a A Reference
       Region 5z7a A 1-17 disorder
       Region 5z7a A 18-81 order
       Region 5z7a A 82-85 disorder
       Region 5z7a A 86-126 order
 Evidence X-RAY 5z7a B Reference
       Region 5z7a B 1-17 disorder
       Region 5z7a B 18-83 order
       Region 5z7a B 84-88 disorder
       Region 5z7a B 89-126 order
Seq 10-126 Hetero tetramer : IID01021Complex
 Evidence X-RAY 5z7l A Reference
       Region 5z7l A 10-17 disorder
       Region 5z7l A 18-126 order
 Evidence X-RAY 5z7l B Reference
       Region 5z7l B 10-16 disorder
       Region 5z7l B 17-126 order
Seq 10-141 Hetero tetramer : IID00998Complex
 Evidence X-RAY 7eaa A Reference
       Region 7eaa A 10-11 order
       Region 7eaa A 12-20 disorder
       Region 7eaa A 21-78 order
       Region 7eaa A 79-85 disorder
       Region 7eaa A 86-126 order
       Region 7eaa A 127-141 disorder
 Evidence X-RAY 7eaa B Reference
       Region 7eaa B 10-78 order
       Region 7eaa B 79-85 disorder
       Region 7eaa B 86-125 order
       Region 7eaa B 126-141 disorder
Seq 21-141 Hetero dimer : IID01013Complex
 Evidence X-RAY 3vvw A Reference
       Region 3vvw A 21-80 order
       Region 3vvw A 81-87 disorder
       Region 3vvw A 88-137 order
       Region 3vvw A 138-141 disorder
Seqdisorder 365-391
 Evidence NMR The solution structure of the C-terminal region of CALCOCO2 (residues 365-446) was determined. In the final structure, the extreme C-terminal region, including the second CPXC motif of CALCOCO2 (ZF1 domain, residues 414-446) was well defined, and a short alpha-helix in the ZF1 domain (residues 392-413), whereas the remaining region was too flexible to be well defined (Fig. S2C and D). Reference
       Region 365-391 disorder
Seq 368-381 Hetero dimer : O00214
 Evidence X-RAY 4gxl B Reference
       Region 4gxl B 368-370 disorder
       Region 4gxl B 371-381 order
Seq 372-385 Hetero hexamer : O00214
 Evidence X-RAY 4han C Reference
       Region 4han C 372-380 order
       Region 4han C 381-385 disorder
 Evidence X-RAY 4han D Reference
       Region 4han D 372-380 order
       Region 4han D 381-385 disorder
Seq 388-446 Monomer :
 Evidence NMR 5aaq A Reference
       Region 5aaq A 388-389 disorder
       Region 5aaq A 390-446 order
       Region 5aaq A 390-414 high_rmsd
Seq 414-446 Monomer :
 Evidence NMR 2mxp A Reference
       Region 2mxp A 414-446 order
       Region 2mxp A 414-415 high_rmsd
Seq 414-446 Hetero dimer : P62987
 Evidence X-RAY 4xkl B Reference
       Region 4xkl B 414-416 disorder
       Region 4xkl B 417-446 order
 Evidence X-RAY 4xkl D Reference
       Region 4xkl D 414-415 disorder
       Region 4xkl D 416-446 order
SeqProS verified 133-137 CLIR (LC3C-interacting region), a noncanonical LIR Hetero dimer : IID01013Complex
       Region 3vvw A 88-137 order
       Region 3vvv A 133-141 disorder
SeqProS verified 371-381 Hetero dimer : O00214
       Region 4gxl B 371-381 order
       Region 365-391 disorder
SeqProS verified 371-381 Hetero hexamer : O00214
       Region 4han C 372-380 order
       Region 4han D 372-380 order
       Region 365-391 disorder
Seqphosphorylation
    445-445 Phosphoserine
 
Prediction
NeProc
Disorder 1-15,123-134,205-208,349-415
Order 16-122,135-204,209-348,416-446
ProS 123-134,205-208,349-352,372-385,393-410
AlphaFold
Disorder 1-20,79-87,128-137,345-418
Order 21-78,88-127,138-344,419-446
SEG 176-185
Function
Function in SwissProt
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).