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IID00973
 UniprotQ13148
ProteinTAR DNA-binding protein 43
GeneTARDBP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
414
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-80 Homo pentamer :
 Evidence X-RAY 6t4b A Reference
       Region 6t4b A 1-1 disorder
       Region 6t4b A 2-79 order
       Region 6t4b A 80-80 disorder
 Evidence X-RAY 6t4b C Reference
       Region 6t4b C 1-79 order
       Region 6t4b C 80-80 disorder
 Evidence X-RAY 6t4b E Reference
       Region 6t4b E 1-1 disorder
       Region 6t4b E 2-79 order
       Region 6t4b E 80-80 disorder
 Evidence X-RAY 6t4b G Reference
       Region 6t4b G 1-2 disorder
       Region 6t4b G 3-79 order
       Region 6t4b G 80-80 disorder
 Evidence X-RAY 6t4b I Reference
       Region 6t4b I 1-1 disorder
       Region 6t4b I 2-79 order
       Region 6t4b I 80-80 disorder
Seq 1-80 Homo dimer :
 Evidence NMR 6b1g A Reference
       Region 6b1g A 1-80 order
 Evidence NMR 6b1g B Reference
       Region 6b1g B 1-80 order
Seq 1-102 Monomer :
 Evidence NMR 2n4p A Reference
       Region 2n4p A 1-77 order
 Evidence X-RAY 5mdi A Reference
       Region 5mdi A 2-79 order
       Region 5mdi A 80-80 disorder
 Evidence X-RAY 5mdi B Reference
       Region 5mdi B 2-79 order
       Region 5mdi B 80-80 disorder
 Evidence NMR 5mrg A Reference
       Region 5mrg A 1-102 order
 Evidence NMR 5x4f A Reference
       Region 5x4f A 1-77 order
Seq 79-102 Hetero dimer : IID00153Complex
 Evidence X-RAY 7n9h A Reference
       Region 7n9h A 79-79 disorder
       Region 7n9h A 80-102 order
Seq 96-191 Monomer :
 Evidence NMR 2cqg A Reference
       Region 2cqg A 96-185 order
       Region 2cqg A 96-101 high_rmsd
       Region 2cqg A 184-185 high_rmsd
 Evidence X-RAY 4iuf A Reference
       Region 4iuf A 103-179 order
 Evidence X-RAY 4y00 A Reference
       Region 4y00 A 101-102 disorder
       Region 4y00 A 103-180 order
       Region 4y00 A 181-191 disorder
 Evidence X-RAY 4y00 B Reference
       Region 4y00 B 101-102 disorder
       Region 4y00 B 103-180 order
       Region 4y00 B 181-191 disorder
 Evidence X-RAY 4y00 C Reference
       Region 4y00 C 101-102 disorder
       Region 4y00 C 103-179 order
       Region 4y00 C 180-191 disorder
 Evidence X-RAY 4y00 D Reference
       Region 4y00 D 101-102 disorder
       Region 4y00 D 103-179 order
       Region 4y00 D 180-191 disorder
 Evidence X-RAY 4y0f A Reference
       Region 4y0f A 101-102 disorder
       Region 4y0f A 103-180 order
       Region 4y0f A 181-191 disorder
 Evidence X-RAY 4y0f B Reference
       Region 4y0f B 101-102 disorder
       Region 4y0f B 103-179 order
       Region 4y0f B 180-191 disorder
Seq 102-269 Monomer :
 Evidence NMR 4bs2 A Reference
       Region 4bs2 A 102-269 order
Seq 193-267 Monomer :
 Evidence NMR 1wf0 A Reference
       Region 1wf0 A 193-267 order
       Region 1wf0 A 266-267 high_rmsd
Seq 248-253 Homo dodecamer :
 Evidence X-RAY 5w50 A Reference
       Region 5w50 A 248-253 order
 Evidence X-RAY 5w50 B Reference
       Region 5w50 B 248-253 order
Seqdisorder 263-414
 Evidence CD¸ NMR Reference
       Region 263-414 disorder
Seq 300-306 Homo decamer :
 Evidence X-RAY 5wkd A Reference
       Region 5wkd A 300-306 order
Seq 307-360 Monomer :
 Evidence NMR 2n2c A Reference
       Region 2n2c A 307-349 order
       Region 2n2c A 307-308 high_rmsd
       Region 2n2c A 348-349 high_rmsd
 Evidence NMR 2n3x A Reference
       Region 2n3x A 311-360 order
       Region 2n3x A 311-319 high_rmsd
       Region 2n3x A 346-360 high_rmsd
 Evidence NMR 2n4g A Reference
       Region 2n4g A 311-360 order
       Region 2n4g A 311-317 high_rmsd
       Region 2n4g A 332-360 high_rmsd
 Evidence NMR 2n4h A Reference
       Region 2n4h A 311-360 order
       Region 2n4h A 311-319 high_rmsd
       Region 2n4h A 337-360 high_rmsd
 Evidence NMR 8a6i A Reference
       Region 8a6i A 309-348 order
       Region 8a6i A 349-350 disorder
Seq 312-317 Homo pentadecamer :
 Evidence X-RAY 5whn A Reference
       Region 5whn A 312-317 order
Seq 312-317 Monomer :
 Evidence X-RAY 5whp A Reference
       Region 5whp A 312-317 order
Seq 370-375 Homo decamer :
 Evidence X-RAY 5wia A Reference
       Region 5wia A 370-375 order
Seq 396-402 Homo decamer :
 Evidence X-RAY 5wiq A Reference
       Region 5wiq A 396-402 order
 Evidence X-RAY 5wiq B Reference
       Region 5wiq B 396-402 order
SeqProS possible 80-102 Nuclear Localization Signal (NLS) Hetero dimer : IID00153Complex
       Region 7n9h A 80-102 order
SeqProS verified 300-402 prion-like domains Homo pentadecamer :
       Region 5whn A 312-317 order
       Region 263-414 disorder
SeqProS verified 300-402 prion-like domains Homo decamer :
       Region 5wiq A 396-402 order
       Region 5wiq B 396-402 order
       Region 263-414 disorder
SeqProS verified 300-402 prion-like domains Homo decamer :
       Region 5wia A 370-375 order
       Region 263-414 disorder
SeqProS verified 300-402 prion-like domains :
       Region 2n4g A 311-360 order
       Region 2n3x A 311-360 order
       Region 2n2c A 307-349 order
       Region 2n4h A 311-360 order
       Region 8a6i A 309-348 order
       Region 263-414 disorder
SeqProS verified 300-402 prion-like domains :
       Region 5whp A 312-317 order
       Region 263-414 disorder
SeqProS verified 300-402 prion-like domains Homo decamer :
       Region 5wkd A 300-306 order
       Region 263-414 disorder
Seqphosphorylation
    292-292 Phosphoserine
    183-183 Phosphoserine
 
Prediction
NeProc
Disorder 80-101,181-189,264-414
Order 1-79,102-180,190-263
ProS 80-96,181-184,274-337,368-372,382-386,395-414
AlphaFold
Disorder 1-2,79-103,179-190,261-414
Order 3-78,104-178,191-260
SEG 272-314 ,321-329 ,342-358 ,368-404
Function
Function in SwissProt
RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:23398327, PubMed:19765185). Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563).