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IID00975
 UniprotQ13362
ProteinSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
GenePPP2R5C
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
524
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-442 Hetero trimer : IID00958Complex,P30153
 Evidence X-RAY 2npp E Reference
       Region 2npp E 1-37 disorder
       Region 2npp E 38-425 order
       Region 2npp E 426-442 disorder
 Evidence X-RAY 2npp B Reference
       Region 2npp B 1-37 disorder
       Region 2npp B 38-425 order
       Region 2npp B 426-442 disorder
 Evidence X-RAY 2nyl B Reference
       Region 2nyl B 38-425 order
 Evidence X-RAY 2nyl E Reference
       Region 2nyl E 38-425 order
 Evidence X-RAY 2nym B Reference
       Region 2nym B 38-425 order
 Evidence X-RAY 2nym E Reference
       Region 2nym E 38-425 order
Seq 11-380 Monomer :
 Evidence X-RAY 2jak A Reference
       Region 2jak A 11-29 disorder
       Region 2jak A 30-33 order
       Region 2jak A 34-34 disorder
       Region 2jak A 35-109 order
       Region 2jak A 110-124 disorder
       Region 2jak A 125-372 order
       Region 2jak A 373-380 disorder
Seq 30-380 Hetero dimer : IID00407Complex
 Evidence X-RAY 5jja A Reference
       Region 5jja A 30-109 order
       Region 5jja A 110-123 disorder
       Region 5jja A 124-375 order
       Region 5jja A 376-380 disorder
 Evidence X-RAY 5jja B Reference
       Region 5jja B 30-109 order
       Region 5jja B 110-123 disorder
       Region 5jja B 124-376 order
       Region 5jja B 377-380 disorder
 Evidence X-RAY 5k6s A Reference
       Region 5k6s A 31-36 disorder
       Region 5k6s A 37-109 order
       Region 5k6s A 110-127 disorder
       Region 5k6s A 128-377 order
       Region 5k6s A 378-380 disorder
 Evidence X-RAY 5swf A Reference
       Region 5swf A 31-35 disorder
       Region 5swf A 36-108 order
       Region 5swf A 109-127 disorder
       Region 5swf A 128-377 order
       Region 5swf A 378-380 disorder
Seq 30-436 Hetero trimer : IID00958Complex,Q76MZ3
 Evidence X-RAY 2iae B Reference
       Region 2iae B 30-30 disorder
       Region 2iae B 31-406 order
       Region 2iae B 407-436 disorder
 Evidence X-RAY 2iae E Reference
       Region 2iae E 30-406 order
       Region 2iae E 407-436 disorder
Seq 31-380 Hetero dimer : IID00984Complex
 Evidence X-RAY 5sw9 A Reference
       Region 5sw9 A 31-35 disorder
       Region 5sw9 A 36-109 order
       Region 5sw9 A 110-127 disorder
       Region 5sw9 A 128-377 order
       Region 5sw9 A 378-380 disorder
Seq 31-380 Hetero dimer : IID00923Complex
 Evidence X-RAY 6oyl A Reference
       Region 6oyl A 31-36 disorder
       Region 6oyl A 37-109 order
       Region 6oyl A 110-127 disorder
       Region 6oyl A 128-377 order
       Region 6oyl A 378-380 disorder
Seq 31-380 Hetero dimer : IID01035Complex
 Evidence X-RAY 6vro A Reference
       Region 6vro A 31-32 disorder
       Region 6vro A 33-53 order
       Region 6vro A 54-60 disorder
       Region 6vro A 61-107 order
       Region 6vro A 108-125 disorder
       Region 6vro A 126-376 order
       Region 6vro A 377-380 disorder
Seq 34-436 Hetero tetramer : IID00958Complex,IID00983Complex,Q76MZ3
 Evidence X-RAY 3fga B Reference
       Region 3fga B 34-436 order
SeqProS verified 110-124 Hetero tetramer : IID00958Complex,IID00983Complex,Q76MZ3
       Region 3fga B 34-436 order
       Region 2jak A 110-124 disorder
SeqProS verified 110-124 Hetero trimer : IID00958Complex,P30153
       Region 2npp B 38-425 order
       Region 2npp E 38-425 order
       Region 2nym B 38-425 order
       Region 2nym E 38-425 order
       Region 2nyl B 38-425 order
       Region 2nyl E 38-425 order
       Region 2jak A 110-124 disorder
SeqProS verified 110-124 Hetero trimer : IID00958Complex,Q76MZ3
       Region 2iae B 31-406 order
       Region 2iae E 30-406 order
       Region 2jak A 110-124 disorder
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-23,116-121,446-524
Order 24-115,122-445
ProS 15-23,116-121,468-482,492-524
AlphaFold
Disorder 1-24,444-524
Order 25-443
SEG 247-262 ,413-429
Function
Function in SwissProt
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.