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IID00979
 UniprotQ15059
ProteinBromodomain-containing protein 3
GeneBRD3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
726
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 24-144 Hetero tetramer : P61978
 Evidence X-RAY 7rjk A Reference
       Region 7rjk A 24-144 order
 Evidence X-RAY 7rjk B Reference
       Region 7rjk B 24-143 order
       Region 7rjk B 144-144 disorder
Seq 24-144 Hetero tetramer : Q9NYF8
 Evidence X-RAY 7rjn A Reference
       Region 7rjn A 24-143 order
       Region 7rjn A 144-144 disorder
 Evidence X-RAY 7rjn B Reference
       Region 7rjn B 24-142 order
       Region 7rjn B 143-144 disorder
Seq 24-144 Hetero trimer : Q12906
 Evidence X-RAY 7rjm A Reference
       Region 7rjm A 24-34 disorder
       Region 7rjm A 35-144 order
 Evidence X-RAY 7rjm B Reference
       Region 7rjm B 24-142 order
       Region 7rjm B 143-144 disorder
Seq 24-144 Hetero trimer : P34896
 Evidence X-RAY 7rjl A Reference
       Region 7rjl A 24-143 order
       Region 7rjl A 144-144 disorder
 Evidence X-RAY 7rjl B Reference
       Region 7rjl B 24-31 disorder
       Region 7rjl B 32-144 order
Seq 24-147 Homo dimer :
 Evidence X-RAY 3s91 A Reference
       Region 3s91 A 24-35 disorder
       Region 3s91 A 36-142 order
       Region 3s91 A 143-144 disorder
 Evidence X-RAY 7lay A Reference
       Region 7lay A 24-142 order
       Region 7lay A 143-144 disorder
 Evidence X-RAY 7lay B Reference
       Region 7lay B 24-32 disorder
       Region 7lay B 33-144 order
 Evidence X-RAY 7laz A Reference
       Region 7laz A 24-24 disorder
       Region 7laz A 25-142 order
       Region 7laz A 143-144 disorder
 Evidence X-RAY 7laz B Reference
       Region 7laz B 24-24 disorder
       Region 7laz B 25-142 order
       Region 7laz B 143-144 disorder
 Evidence X-RAY 6qju A Reference
       Region 6qju A 24-33 disorder
       Region 6qju A 34-144 order
 Evidence X-RAY 6qju B Reference
       Region 6qju B 24-143 order
       Region 6qju B 144-144 disorder
 Evidence X-RAY 7toa A Reference
       Region 7toa A 32-147 order
 Evidence X-RAY 7toa B Reference
       Region 7toa B 32-147 order
 Evidence X-RAY 6u4a A Reference
       Region 6u4a A 25-27 disorder
       Region 6u4a A 28-147 order
 Evidence X-RAY 6u4a B Reference
       Region 6u4a B 25-147 order
Seq 24-155 Monomer :
 Evidence X-RAY 2nxb A Reference
       Region 2nxb A 24-33 disorder
       Region 2nxb A 34-144 order
 Evidence X-RAY 2nxb B Reference
       Region 2nxb B 24-143 order
       Region 2nxb B 144-144 disorder
 Evidence X-RAY 7r8r A Reference
       Region 7r8r A 24-30 disorder
       Region 7r8r A 31-144 order
 Evidence NMR 2yw5 A Reference
       Region 2yw5 A 25-155 order
       Region 2yw5 A 152-155 high_rmsd
Seq 25-147 Hetero trimer :
 Evidence X-RAY 7to9 A Reference
       Region 7to9 A 25-31 disorder
       Region 7to9 A 32-147 order
 Evidence X-RAY 7to9 B Reference
       Region 7to9 B 25-31 disorder
       Region 7to9 B 32-147 order
Seq 25-147 Hetero hexamer :
 Evidence X-RAY 7to7 A Reference
       Region 7to7 A 25-32 disorder
       Region 7to7 A 33-147 order
 Evidence X-RAY 7to7 B Reference
       Region 7to7 B 25-25 disorder
       Region 7to7 B 26-141 order
       Region 7to7 B 142-147 disorder
 Evidence X-RAY 7to7 D Reference
       Region 7to7 D 25-27 order
       Region 7to7 D 28-31 disorder
       Region 7to7 D 32-147 order
 Evidence X-RAY 7to7 E Reference
       Region 7to7 E 25-33 disorder
       Region 7to7 E 34-147 order
Seq 25-147 Hetero trimer :
 Evidence X-RAY 7to8 A Reference
       Region 7to8 A 25-31 disorder
       Region 7to8 A 32-147 order
 Evidence X-RAY 7to8 B Reference
       Region 7to8 B 25-31 disorder
       Region 7to8 B 32-147 order
Seq 245-253 Hetero octamer : IID00529Complex
 Evidence X-RAY 6i68 B Reference
       Region 6i68 B 245-251 order
       Region 6i68 B 252-253 disorder
 Evidence X-RAY 6i68 D Reference
       Region 6i68 D 245-250 order
       Region 6i68 D 251-253 disorder
 Evidence X-RAY 6i68 F Reference
       Region 6i68 F 245-253 order
 Evidence X-RAY 6i68 H Reference
       Region 6i68 H 245-251 order
       Region 6i68 H 252-253 disorder
Seq 245-253 Hetero dimer : IID00529Complex
 Evidence X-RAY 6i41 B Reference
       Region 6i41 B 245-251 order
       Region 6i41 B 252-253 disorder
Seq 245-253 Hetero octamer : IID00529Complex
 Evidence X-RAY 6i7a B Reference
       Region 6i7a B 245-251 order
       Region 6i7a B 252-253 disorder
 Evidence X-RAY 6i7a D Reference
       Region 6i7a D 245-251 order
       Region 6i7a D 252-253 disorder
 Evidence X-RAY 6i7a F Reference
       Region 6i7a F 245-251 order
       Region 6i7a F 252-253 disorder
 Evidence X-RAY 6i7a H Reference
       Region 6i7a H 245-251 order
       Region 6i7a H 252-253 disorder
Seq 245-253 Hetero octamer : IID00529Complex
 Evidence X-RAY 6i5p B Reference
       Region 6i5p B 245-251 order
       Region 6i5p B 252-253 disorder
 Evidence X-RAY 6i5p D Reference
       Region 6i5p D 245-250 order
       Region 6i5p D 251-253 disorder
 Evidence X-RAY 6i5p F Reference
       Region 6i5p F 245-251 order
       Region 6i5p F 252-253 disorder
 Evidence X-RAY 6i5p H Reference
       Region 6i5p H 245-251 order
       Region 6i5p H 252-253 disorder
Seq 306-416 Homo dimer :
 Evidence X-RAY 7lb4 A Reference
       Region 7lb4 A 306-308 disorder
       Region 7lb4 A 309-416 order
 Evidence X-RAY 7lb4 B Reference
       Region 7lb4 B 306-308 disorder
       Region 7lb4 B 309-416 order
Seq 306-416 Homo tetramer :
 Evidence X-RAY 7ug5 A Reference
       Region 7ug5 A 306-306 disorder
       Region 7ug5 A 307-416 order
 Evidence X-RAY 7ug5 B Reference
       Region 7ug5 B 306-416 order
 Evidence X-RAY 7ug5 C Reference
       Region 7ug5 C 306-306 disorder
       Region 7ug5 C 307-416 order
 Evidence X-RAY 7ug5 D Reference
       Region 7ug5 D 306-416 order
Seq 306-416 Homo tetramer :
 Evidence X-RAY 7lbt A Reference
       Region 7lbt A 306-416 order
 Evidence X-RAY 7lbt B Reference
       Region 7lbt B 306-307 disorder
       Region 7lbt B 308-416 order
 Evidence X-RAY 7lbt C Reference
       Region 7lbt C 306-306 disorder
       Region 7lbt C 307-416 order
 Evidence X-RAY 7lbt D Reference
       Region 7lbt D 306-416 order
Seq 306-416 Monomer :
 Evidence X-RAY 5a7c A Reference
       Region 5a7c A 306-416 order
 Evidence X-RAY 5a7c B Reference
       Region 5a7c B 306-416 order
 Evidence X-RAY 5a7c C Reference
       Region 5a7c C 306-307 disorder
       Region 5a7c C 308-416 order
 Evidence X-RAY 5a7c D Reference
       Region 5a7c D 306-307 disorder
       Region 5a7c D 308-416 order
 Evidence X-RAY 5hfr A Reference
       Region 5hfr A 306-306 disorder
       Region 5hfr A 307-416 order
 Evidence X-RAY 5hfr B Reference
       Region 5hfr B 306-306 disorder
       Region 5hfr B 307-416 order
 Evidence X-RAY 5hfr C Reference
       Region 5hfr C 306-307 disorder
       Region 5hfr C 308-416 order
 Evidence X-RAY 5hfr D Reference
       Region 5hfr D 306-307 disorder
       Region 5hfr D 308-416 order
 Evidence X-RAY 2oo1 A Reference
       Region 2oo1 A 307-416 order
 Evidence X-RAY 2oo1 B Reference
       Region 2oo1 B 307-416 order
 Evidence X-RAY 2oo1 C Reference
       Region 2oo1 C 307-416 order
 Evidence X-RAY 2oo1 D Reference
       Region 2oo1 D 307-416 order
 Evidence X-RAY 3s92 A Reference
       Region 3s92 A 306-306 disorder
       Region 3s92 A 307-416 order
 Evidence NMR 2e7n A Reference
       Region 2e7n A 306-415 order
       Region 2e7n A 306-306 high_rmsd
 Evidence X-RAY 7l72 A Reference
       Region 7l72 A 306-416 order
 Evidence X-RAY 7l9l A Reference
       Region 7l9l A 306-416 order
Seq 306-416 Homo undecamer :
 Evidence X-RAY 7s3p A Reference
       Region 7s3p A 306-308 disorder
       Region 7s3p A 309-416 order
 Evidence X-RAY 7s3p B Reference
       Region 7s3p B 306-308 disorder
       Region 7s3p B 309-416 order
 Evidence X-RAY 7s3p C Reference
       Region 7s3p C 306-308 disorder
       Region 7s3p C 309-416 order
 Evidence X-RAY 7s3p D Reference
       Region 7s3p D 306-308 disorder
       Region 7s3p D 309-416 order
 Evidence X-RAY 7s3p E Reference
       Region 7s3p E 306-307 disorder
       Region 7s3p E 308-416 order
 Evidence X-RAY 7s3p F Reference
       Region 7s3p F 306-308 disorder
       Region 7s3p F 309-416 order
 Evidence X-RAY 7s3p G Reference
       Region 7s3p G 306-308 disorder
       Region 7s3p G 309-416 order
 Evidence X-RAY 7s3p H Reference
       Region 7s3p H 306-308 disorder
       Region 7s3p H 309-416 order
 Evidence X-RAY 7s3p I Reference
       Region 7s3p I 306-308 disorder
       Region 7s3p I 309-416 order
 Evidence X-RAY 7s3p J Reference
       Region 7s3p J 306-308 disorder
       Region 7s3p J 309-416 order
 Evidence X-RAY 7s3p K Reference
       Region 7s3p K 306-308 disorder
       Region 7s3p K 309-416 order
Seq 307-416 Hetero dimer : IID00058Complex
 Evidence X-RAY 8b5a A Reference
       Region 8b5a A 307-416 order
Seq 307-416 Hetero dimer : IID00062Complex
 Evidence X-RAY 5hjc A Reference
       Region 5hjc A 307-416 order
Seq 307-419 Hetero dimer :
 Evidence X-RAY 8cv5 A Reference
       Region 8cv5 A 307-418 order
       Region 8cv5 A 419-419 disorder
Seq 307-419 Homo dimer :
 Evidence X-RAY 6ulp A Reference
       Region 6ulp A 307-416 order
       Region 6ulp A 417-419 disorder
 Evidence X-RAY 6ulp B Reference
       Region 6ulp B 307-307 disorder
       Region 6ulp B 308-416 order
       Region 6ulp B 417-419 disorder
Seq 554-640 Hetero dimer : IID00496Complex
 Evidence NMR 7jyn A Reference
       Region 7jyn A 554-640 order
       Region 7jyn A 554-567 high_rmsd
       Region 7jyn A 639-640 high_rmsd
Seq 554-640 Hetero dimer : Q8UN00
 Evidence NMR 7jyz B Reference
       Region 7jyz B 554-640 order
       Region 7jyz B 554-564 high_rmsd
Seq 554-640 Hetero dimer : P03355
 Evidence NMR 7jq8 A Reference
       Region 7jq8 A 554-640 order
       Region 7jq8 A 554-567 high_rmsd
       Region 7jq8 A 640-640 high_rmsd
Seq 554-640 Monomer :
 Evidence NMR 7jmy A Reference
       Region 7jmy A 554-640 order
       Region 7jmy A 554-566 high_rmsd
Seq 557-643 Hetero dimer : IID00945Complex
 Evidence NMR 6bgh A Reference
       Region 6bgh A 557-643 order
       Region 6bgh A 557-569 high_rmsd
       Region 6bgh A 640-643 high_rmsd
Seq 557-644 Hetero dimer : IID00322Complex
 Evidence NMR 6bgg B Reference
       Region 6bgg B 557-644 order
       Region 6bgg B 557-566 high_rmsd
       Region 6bgg B 640-644 high_rmsd
SeqProS predicted 245-253 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : IID00529Complex
       Region 6i7a B 245-251 order
       Region 6i7a D 245-251 order
       Region 6i7a F 245-251 order
       Region 6i7a H 245-251 order
SeqProS predicted 245-253 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : IID00529Complex
       Region 6i68 B 245-251 order
       Region 6i68 D 245-250 order
       Region 6i68 F 245-253 order
       Region 6i68 H 245-251 order
SeqProS predicted 245-253 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00529Complex
       Region 6i41 B 245-251 order
SeqProS predicted 245-253 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : IID00529Complex
       Region 6i5p B 245-251 order
       Region 6i5p D 245-250 order
       Region 6i5p F 245-251 order
       Region 6i5p H 245-251 order
Seqphosphorylation
    263-263 Phosphoserine
    281-281 Phosphoserine
    563-563 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-34,143-308,416-455,484-486,522-569,614-650,679-726
Order 35-142,309-415,456-483,487-521,570-613,651-678
ProS 18-28,161-165,195-202,225-230,287-295,484-486,614-637
AlphaFold
Disorder 1-17,150-306,418-455,482-568,639-655,675-726
Order 18-149,307-417,456-481,569-638,656-674
SEG 16-33 ,149-163 ,208-261 ,419-431 ,436-460 ,483-540 ,564-568 ,646-673 ,692-725
Function
Function in SwissProt
Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:32895492, PubMed:22464331, PubMed:27105114). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:32895492, PubMed:29567837). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).