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IID00980
 UniprotQ15154
ProteinPericentriolar material 1 protein
GenePCM1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2024
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1737-1751 Hetero hexamer : O95714
 Evidence X-RAY 7q46 B Reference
       Region 7q46 B 1737-1745 order
       Region 7q46 B 1746-1751 disorder
 Evidence X-RAY 7q46 D Reference
       Region 7q46 D 1737-1744 order
       Region 7q46 D 1745-1751 disorder
 Evidence X-RAY 7q46 F Reference
       Region 7q46 F 1737-1742 order
       Region 7q46 F 1743-1751 disorder
Seq 1959-1972 Hetero tetramer : IID00921Complex
 Evidence X-RAY 6hyl A Reference
       Region 6hyl A 1959-1961 disorder
       Region 6hyl A 1962-1972 order
 Evidence X-RAY 6hyl B Reference
       Region 6hyl B 1959-1961 disorder
       Region 6hyl B 1962-1972 order
Seq 1959-1972 Hetero tetramer : IID00921Complex
 Evidence X-RAY 6hym A Reference
       Region 6hym A 1959-1960 disorder
       Region 6hym A 1961-1972 order
 Evidence X-RAY 6hym B Reference
       Region 6hym B 1959-1972 order
SeqProS predicted 1959-1972 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00921Complex
       Region 6hyl A 1962-1972 order
       Region 6hyl B 1962-1972 order
SeqProS predicted 1959-1972 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00921Complex
       Region 6hym A 1961-1972 order
       Region 6hym B 1959-1972 order
Seqphosphorylation
    1977-1977 Phosphoserine
    1958-1958 Phosphoserine
    1782-1782 Phosphoserine
    1776-1776 Phosphoserine
    1768-1768 Phosphoserine
    1765-1765 Phosphoserine
    1730-1730 Phosphoserine
    1697-1697 Phosphoserine
    1573-1573 Phosphoserine
    1468-1468 Phosphothreonine
    1320-1320 Phosphoserine
    1318-1318 Phosphoserine
    1263-1263 Phosphoserine
    1262-1262 Phosphoserine
    1260-1260 Phosphoserine
    1257-1257 Phosphoserine
    1231-1231 Phosphoserine
    1229-1229 Phosphoserine
    1188-1188 Phosphoserine
    1185-1185 Phosphoserine
    991-991 Phosphoserine
    988-988 Phosphoserine
    977-977 Phosphoserine
    960-960 Phosphoserine
    877-877 Phosphothreonine
    872-872 Phosphoserine
    869-869 Phosphoserine
    866-866 Phosphoserine
    861-861 Phosphoserine
    859-859 Phosphothreonine
    643-643 Phosphoserine
    588-588 Phosphoserine
    384-384 Phosphoserine
    372-372 Phosphoserine; by PLK4
    370-370 Phosphoserine
    159-159 Phosphoserine; in variant Ser-159
    119-119 Phosphoserine
    116-116 Phosphoserine
    110-110 Phosphoserine
    93-93 Phosphoserine
    69-69 Phosphoserine
    68-68 Phosphoserine
    65-65 Phosphoserine
Seqacetylation
    399-399 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-265,301-654,683-724,777-821,861-995,1024-1057,1086-1376,1433-1589,1697-1982,1985-2024
Order 266-300,655-682,725-776,822-860,996-1023,1058-1085,1377-1432,1590-1696,1983-1984
ProS 4-37,51-66,74-90,97-114,127-132,141-154,195-218,234-265,301-318,340-354,361-375,395-424,453-457,482-511,519-523,546-549,556-561,568-573,581-595,601-618,650-654,693-697,709-715,819-821,870-873,880-896,905-912,926-965,981-988,1024-1031,1039-1046,1051-1057,1109-1116,1122-1148,1166-1183,1209-1216,1249-1276,1288-1302,1308-1316,1324-1330,1355-1362,1433-1433,1449-1487,1503-1536,1543-1547,1581-1589,1697-1704,1734-1738,1754-1760,1778-1800,1870-1877,1961-1982,1990-2024
AlphaFold
Disorder 1-94,103-104,106-200,263-270,318-337,351-393,424-486,521-653,655-655,678-678,680-728,770-820,853-978,988-988,1037-1049,1086-1376,1435-1516,1534-1588,1634-1641,1693-1978,1989-2024
Order 95-102,105-105,201-262,271-317,338-350,394-423,487-520,654-654,656-677,679-679,729-769,821-852,979-987,989-1036,1050-1085,1377-1434,1517-1533,1589-1633,1642-1692,1979-1988
SEG 287-307 ,528-543 ,619-631 ,634-644 ,738-756 ,825-844 ,917-922 ,1024-1036 ,1105-1117 ,1266-1279 ,1290-1304 ,1736-1747 ,1765-1777 ,1800-1813 ,1901-1917
Function
Function in SwissProt
Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (PubMed:34782749).