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IID00981
 UniprotQ15468
ProteinSCL-interrupting locus protein
GeneSTIL
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1287
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 718-749 Monomer :
 Evidence X-RAY 8oyl A Reference
       Region 8oyl A 718-749 order
Seq 718-749 Hetero hexamer :
 Evidence X-RAY 8oyk A Reference
       Region 8oyk A 718-749 order
Seq 720-751 Hetero dimer : IID00908Complex
 Evidence X-RAY 4yyp B Reference
       Region 4yyp B 720-751 order
Seq 726-750 Homo dimer :
 Evidence X-RAY 5lhw A Reference
       Region 5lhw A 726-750 order
Seq 726-750 Hetero dimer : IID00908Complex
 Evidence X-RAY 5lhz D Reference
       Region 5lhz D 726-728 disorder
       Region 5lhz D 729-750 order
 Evidence X-RAY 5lhz E Reference
       Region 5lhz E 726-729 disorder
       Region 5lhz E 730-750 order
 Evidence X-RAY 5lhz F Reference
       Region 5lhz F 726-728 disorder
       Region 5lhz F 729-750 order
Seqphosphorylation
    395-395 Phosphoserine
    753-753 Phosphoserine
    779-779 Phosphoserine
    1135-1135 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-19,359-989,1069-1287
Order 20-358,990-1052,1057-1068
ProS 1-13,359-376,392-404,419-434,468-472,488-493,601-608,616-621,650-656,662-667,696-700,721-745,770-773,795-803,824-829,876-884,893-898,935-952,963-968,975-978,1069-1080,1106-1131,1153-1167,1174-1203,1215-1226,1233-1255,1270-1287
AlphaFold
Disorder 1-22,109-109,132-137,321-324,346-348,359-359,375-718,747-938,945-992,1007-1007,1009-1063,1065-1065,1077-1114,1130-1287
Order 23-108,110-131,138-320,325-345,349-358,360-374,719-746,939-944,993-1006,1008-1008,1064-1064,1066-1076,1115-1129
SEG 729-744 ,1131-1147
Function
Function in SwissProt
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:32107292, PubMed:29712910).