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IID00984
 UniprotQ69YH5
ProteinCell division cycle-associated protein 2
GeneCDCA2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1023
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 383-423 Hetero dimer : P36873
 Evidence X-RAY 5inb B Reference
       Region 5inb B 383-389 disorder
       Region 5inb B 390-422 order
       Region 5inb B 423-423 disorder
Seq 383-441 Hetero dimer : IID00311Complex
 Evidence X-RAY 5ioh B Reference
       Region 5ioh B 383-390 disorder
       Region 5ioh B 391-423 order
       Region 5ioh B 424-441 disorder
 Evidence X-RAY 5ioh D Reference
       Region 5ioh D 383-391 disorder
       Region 5ioh D 392-421 order
       Region 5ioh D 422-441 disorder
Seqdisorder 390-422
 Evidence NMR Reference
       Region 390-422 disorder
Seq 581-601 Hetero dimer : IID00975Complex
 Evidence X-RAY 5sw9 B Reference
       Region 5sw9 B 581-587 disorder
       Region 5sw9 B 588-598 order
       Region 5sw9 B 599-601 disorder
SeqProS verified 390-422 Hetero dimer : P36873
       Region 5inb B 390-422 order
       Region 390-422 disorder
SeqProS verified 390-422 Hetero dimer : IID00311Complex
       Region 5ioh B 391-423 order
       Region 5ioh D 392-421 order
       Region 390-422 disorder
SeqProS predicted 588-598 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00975Complex
       Region 5sw9 B 588-598 order
Seqphosphorylation
    710-710 Phosphoserine
    98-98 Phosphoserine
    1000-1000 Phosphoserine
    977-977 Phosphoserine
    936-936 Phosphoserine
    756-756 Phosphoserine
    120-120 Phosphoserine
    614-614 Phosphoserine
    591-591 Phosphoserine
    437-437 Phosphoserine
    412-412 Phosphothreonine
    407-407 Phosphoserine
    400-400 Phosphoserine
    312-312 Phosphothreonine
    309-309 Phosphoserine
    291-291 Phosphoserine
    210-210 Phosphoserine
    131-131 Phosphoserine
    126-126 Phosphoserine
 
Prediction
NeProc
Disorder 1-110,113-1023
Order 111-112
ProS 1-47,53-74,87-110,129-166,176-187,200-220,256-259,276-283,290-296,393-406,414-423,448-452,614-634,642-662,682-696,720-735,747-761,767-801,831-851,860-882,888-910,922-1020
AlphaFold
Disorder 1-52,72-72,74-96,118-139,154-392,395-396,398-404,410-448,450-596,598-867,881-1023
Order 53-71,73-73,97-117,140-153,393-394,397-397,405-409,449-449,597-597,868-880
SEG 258-272 ,366-381 ,564-571 ,679-691 ,853-863
Function
Function in SwissProt
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.