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IID00986
 UniprotQ6UVJ0
ProteinSpindle assembly abnormal protein 6 homolog
GeneSASS6
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
657
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-152 Monomer :
 Evidence X-RAY 6z4a A Reference
       Region 6z4a A 1-149 order
       Region 6z4a A 150-152 disorder
Seq 211-312 Homo hexamer :
 Evidence X-RAY 6ys4 A Reference
       Region 6ys4 A 211-311 order
       Region 6ys4 A 312-312 disorder
 Evidence X-RAY 6ys4 B Reference
       Region 6ys4 B 211-311 order
       Region 6ys4 B 312-312 disorder
 Evidence X-RAY 6ys4 C Reference
       Region 6ys4 C 211-216 disorder
       Region 6ys4 C 217-311 order
       Region 6ys4 C 312-312 disorder
 Evidence X-RAY 6ys4 D Reference
       Region 6ys4 D 211-224 disorder
       Region 6ys4 D 225-311 order
       Region 6ys4 D 312-312 disorder
 Evidence X-RAY 6ys4 E Reference
       Region 6ys4 E 211-311 order
       Region 6ys4 E 312-312 disorder
 Evidence X-RAY 6ys4 F Reference
       Region 6ys4 F 211-309 order
       Region 6ys4 F 310-312 disorder
Seqphosphorylation
    657-657 Phosphoserine
    615-615 Phosphoserine
    510-510 Phosphoserine
 
Prediction
NeProc
Disorder 112-117,482-657
Order 1-35,41-111,118-481
ProS 482-484,559-562,591-615,646-653
AlphaFold
Disorder 1-1,19-19,37-40,115-116,383-383,446-446,449-449,463-467,469-657
Order 2-18,20-36,41-114,117-382,384-445,447-448,450-462,468-468
SEG 223-235 ,410-430
Function
Function in SwissProt
Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124).