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IID00993
 UniprotQ8IXH6
ProteinTumor protein p53-inducible nuclear protein 2
GeneTP53INP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
220
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 26-40 Hetero dimer : IID00921Complex
 Evidence X-RAY 7yo9 A Reference
       Region 7yo9 A 26-40 order
 
Prediction
NeProc
Disorder 1-171,200-220
Order 172-199
ProS 1-13,32-43,67-112,150-165,171-171,206-220
AlphaFold
Disorder 1-32,42-72,77-94,98-98,100-162,199-210,220-220
Order 33-41,73-76,95-97,99-99,163-198,211-219
SEG 5-16 ,45-65 ,139-183
Function
Function in SwissProt
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.