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IID00995
 UniprotQ8NC44
ProteinReticulophagy regulator 2
GeneRETREG2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
543
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 400-408 Hetero octamer : P04439
 Evidence X-RAY 6ewc C Reference
       Region 6ewc C 400-408 order
 Evidence X-RAY 6ewc G Reference
       Region 6ewc G 400-408 order
Seqphosphorylation
    385-385 Phosphoserine
    347-347 Phosphoserine
    344-344 Phosphoserine
    337-337 Phosphoserine
    334-334 Phosphothreonine
    311-311 Phosphoserine
    291-291 Phosphoserine
    283-283 Phosphoserine
    281-281 Phosphoserine
    279-279 Phosphothreonine
 
Prediction
NeProc
Disorder 1-48,105-110,133-139,257-543
Order 49-104,111-132,140-256
ProS 9-22,105-110,133-139,257-262,288-302,317-325,346-378,404-412,488-511,532-533
AlphaFold
Disorder 1-36,101-101,121-152,225-226,229-229,262-295,307-501,503-507,509-543
Order 37-100,102-120,153-224,227-228,230-261,296-306,502-502,508-508
SEG 3-31 ,33-48 ,89-119 ,274-288 ,356-373 ,386-390 ,458-496 ,506-525
Function
Function in SwissProt
Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity).