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IID00996
 UniprotQ8NEB9
ProteinPhosphatidylinositol 3-kinase catalytic subunit type 3
GenePIK3C3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
887
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 244-258 Hetero dimer : IID00921Complex
 Evidence X-RAY 6hog A Reference
       Region 6hog A 244-246 disorder
       Region 6hog A 247-255 order
       Region 6hog A 256-258 disorder
Seq 244-258 Hetero octamer : IID00921Complex
 Evidence X-RAY 6hoh A Reference
       Region 6hoh A 244-246 disorder
       Region 6hoh A 247-258 order
 Evidence X-RAY 6hoh B Reference
       Region 6hoh B 244-258 order
 Evidence X-RAY 6hoh C Reference
       Region 6hoh C 244-245 disorder
       Region 6hoh C 246-258 order
 Evidence X-RAY 6hoh D Reference
       Region 6hoh D 244-246 disorder
       Region 6hoh D 247-257 order
       Region 6hoh D 258-258 disorder
Seq 268-887 Monomer :
 Evidence X-RAY 3ihy A Reference
       Region 3ihy A 282-415 order
       Region 3ihy A 416-470 disorder
       Region 3ihy A 471-871 order
       Region 3ihy A 872-879 disorder
 Evidence X-RAY 3ihy B Reference
       Region 3ihy B 282-415 order
       Region 3ihy B 416-471 disorder
       Region 3ihy B 472-871 order
       Region 3ihy B 872-879 disorder
 Evidence X-RAY 3ihy C Reference
       Region 3ihy C 282-417 order
       Region 3ihy C 418-472 disorder
       Region 3ihy C 473-871 order
       Region 3ihy C 872-879 disorder
 Evidence X-RAY 3ihy D Reference
       Region 3ihy D 282-285 disorder
       Region 3ihy D 286-415 order
       Region 3ihy D 416-470 disorder
       Region 3ihy D 471-871 order
       Region 3ihy D 872-879 disorder
 Evidence X-RAY 3ihy E Reference
       Region 3ihy E 282-415 order
       Region 3ihy E 416-472 disorder
       Region 3ihy E 473-871 order
       Region 3ihy E 872-879 disorder
 Evidence X-RAY 3ls8 A Reference
       Region 3ls8 A 268-281 disorder
       Region 3ls8 A 282-415 order
       Region 3ls8 A 416-439 disorder
       Region 3ls8 A 440-452 order
       Region 3ls8 A 453-471 disorder
       Region 3ls8 A 472-871 order
       Region 3ls8 A 872-879 disorder
 Evidence X-RAY 3ls8 B Reference
       Region 3ls8 B 268-295 disorder
       Region 3ls8 B 296-416 order
       Region 3ls8 B 417-470 disorder
       Region 3ls8 B 471-871 order
       Region 3ls8 B 872-879 disorder
 Evidence X-RAY 4oys A Reference
       Region 4oys A 282-285 disorder
       Region 4oys A 286-417 order
       Region 4oys A 418-434 disorder
       Region 4oys A 435-451 order
       Region 4oys A 452-469 disorder
       Region 4oys A 470-873 order
       Region 4oys A 874-879 disorder
 Evidence X-RAY 4ph4 B Reference
       Region 4ph4 B 293-417 order
       Region 4ph4 B 418-470 disorder
       Region 4ph4 B 471-871 order
       Region 4ph4 B 872-887 disorder
 Evidence X-RAY 4uwf A Reference
       Region 4uwf A 282-285 disorder
       Region 4uwf A 286-416 order
       Region 4uwf A 417-434 disorder
       Region 4uwf A 435-450 order
       Region 4uwf A 451-470 disorder
       Region 4uwf A 471-873 order
       Region 4uwf A 874-879 disorder
 Evidence X-RAY 4uwg A Reference
       Region 4uwg A 282-285 disorder
       Region 4uwg A 286-416 order
       Region 4uwg A 417-437 disorder
       Region 4uwg A 438-451 order
       Region 4uwg A 452-470 disorder
       Region 4uwg A 471-869 order
       Region 4uwg A 870-879 disorder
 Evidence X-RAY 4uwh A Reference
       Region 4uwh A 282-284 disorder
       Region 4uwh A 285-417 order
       Region 4uwh A 418-434 disorder
       Region 4uwh A 435-451 order
       Region 4uwh A 452-469 disorder
       Region 4uwh A 470-873 order
       Region 4uwh A 874-879 disorder
 Evidence X-RAY 4uwk A Reference
       Region 4uwk A 282-286 disorder
       Region 4uwk A 287-416 order
       Region 4uwk A 417-437 disorder
       Region 4uwk A 438-451 order
       Region 4uwk A 452-469 disorder
       Region 4uwk A 470-869 order
       Region 4uwk A 870-879 disorder
 Evidence X-RAY 4uwl A Reference
       Region 4uwl A 282-285 disorder
       Region 4uwl A 286-416 order
       Region 4uwl A 417-438 disorder
       Region 4uwl A 439-451 order
       Region 4uwl A 452-470 disorder
       Region 4uwl A 471-869 order
       Region 4uwl A 870-879 disorder
 Evidence X-RAY 5anl A Reference
       Region 5anl A 282-285 disorder
       Region 5anl A 286-416 order
       Region 5anl A 417-438 disorder
       Region 5anl A 439-451 order
       Region 5anl A 452-470 disorder
       Region 5anl A 471-869 order
       Region 5anl A 870-879 disorder
 Evidence X-RAY 5enn A Reference
       Region 5enn A 293-416 order
       Region 5enn A 417-470 disorder
       Region 5enn A 471-872 order
       Region 5enn A 873-887 disorder
 Evidence X-RAY 5enn B Reference
       Region 5enn B 293-417 order
       Region 5enn B 418-470 disorder
       Region 5enn B 471-871 order
       Region 5enn B 872-887 disorder
 Evidence X-RAY 6i3u A Reference
       Region 6i3u A 268-271 disorder
       Region 6i3u A 272-415 order
       Region 6i3u A 416-439 disorder
       Region 6i3u A 440-451 order
       Region 6i3u A 452-471 disorder
       Region 6i3u A 472-871 order
       Region 6i3u A 872-879 disorder
 Evidence X-RAY 7rsj A Reference
       Region 7rsj A 282-286 disorder
       Region 7rsj A 287-417 order
       Region 7rsj A 418-438 disorder
       Region 7rsj A 439-451 order
       Region 7rsj A 452-471 disorder
       Region 7rsj A 472-872 order
       Region 7rsj A 873-879 disorder
Seq 282-879 Homo dimer :
 Evidence X-RAY 7rsp A Reference
       Region 7rsp A 282-285 disorder
       Region 7rsp A 286-415 order
       Region 7rsp A 416-472 disorder
       Region 7rsp A 473-870 order
       Region 7rsp A 871-879 disorder
 Evidence X-RAY 7rsp B Reference
       Region 7rsp B 282-415 order
       Region 7rsp B 416-471 disorder
       Region 7rsp B 472-871 order
       Region 7rsp B 872-879 disorder
 Evidence X-RAY 7rsv A Reference
       Region 7rsv A 282-286 disorder
       Region 7rsv A 287-415 order
       Region 7rsv A 416-471 disorder
       Region 7rsv A 472-871 order
       Region 7rsv A 872-879 disorder
 Evidence X-RAY 7rsv B Reference
       Region 7rsv B 282-415 order
       Region 7rsv B 416-471 disorder
       Region 7rsv B 472-871 order
       Region 7rsv B 872-879 disorder
Seqphosphorylation
    163-163 Phosphothreonine; by AMPK
    165-165 Phosphoserine; by AMPK
    244-244 Phosphoserine
    261-261 Phosphoserine
    282-282 Phosphoserine
 
Prediction
NeProc
Disorder 1-4,161-172,423-468
Order 5-160,173-422,469-887
ProS 161-172,423-450
AlphaFold
Disorder 1-6,46-46,48-49,51-53,163-170,239-263,276-283,415-472,870-883,885-887
Order 7-45,47-47,50-50,54-162,171-238,264-275,284-414,473-869,884-884
Pfam Hmmer
284->530 53-198 630->833
SEG 392-403 ,422-437 ,448-460 ,770-779
Function
Function in SwissProt
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:7628435, PubMed:33637724). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity).
(Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication.