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IID00997
 UniprotQ8NET8
ProteinTransient receptor potential cation channel subfamily V member 3
GeneTRPV3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
790
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 220-246 Hetero dimer : IID00396Complex
 Evidence X-RAY 6ha6 D Reference
       Region 6ha6 D 220-230 disorder
       Region 6ha6 D 231-244 order
       Region 6ha6 D 245-246 disorder
Seq 229-250 Hetero dimer : IID00396Complex
 Evidence X-RAY 6h9j D Reference
       Region 6h9j D 229-250 order
Seq 781-790 Hetero hexamer : IID00700Complex,Q9NSN8
 Evidence X-RAY 7qqn B Reference
       Region 7qqn B 781-785 disorder
       Region 7qqn B 786-790 order
 Evidence X-RAY 7qqn D Reference
       Region 7qqn D 781-784 disorder
       Region 7qqn D 785-790 order
SeqProS predicted 785-790 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero hexamer : IID00700Complex,Q9NSN8
       Region 7qqn B 786-790 order
       Region 7qqn D 785-790 order
 
Prediction
NeProc
Disorder 1-115,754-790
Order 116-753
ProS 1-10,25-56,64-108,754-759,773-790
AlphaFold
Disorder 1-117,149-152,312-313,463-478,509-518,613-618,644-644,646-646,741-790
Order 118-148,153-311,314-462,479-508,519-612,619-643,645-645,647-740
Pfam Hmmer
261->294 214-246 488->677
SEG 81-92 ,106-122 ,132-145 ,228-240 ,441-450
Function
Function in SwissProt
Non-selective calcium permeant cation channel (PubMed:12077604, PubMed:12077606, PubMed:26818531, PubMed:37648856, PubMed:38691614). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius (PubMed:12077604, PubMed:12077606). Activation exhibits an outward rectification (PubMed:12077604). The channel pore can dilate to provide permeability to larger cations (PubMed:37648856). May associate with TRPV1 and may modulate its activity (PubMed:12077606). Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (PubMed:21593771).