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IID01000
 UniprotQ92806
ProteinG protein-activated inward rectifier potassium channel 3
GeneKCNJ9
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
393
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 384-393 Hetero dimer : A9V7E4
 Evidence X-RAY 6x23 B Reference
       Region 6x23 B 384-386 disorder
       Region 6x23 B 387-393 order
SeqProS possible 387-393 PDZ domain-binding motif; this region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : A9V7E4
       Region 6x23 B 387-393 order
 
Prediction
NeProc
Disorder 1-19,341-393
Order 20-340
ProS 5-12,349-354,379-386
AlphaFold
Disorder 1-20,349-393
Order 21-348
SEG 10-23 ,335-345 ,362-376
Function
Function in SwissProt
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).