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IID01001
 UniprotQ92934
ProteinBcl2-associated agonist of cell death
GeneBAD
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
168
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 71-81 Hetero dimer : IID00061Complex
 Evidence X-RAY 7q16 A Reference
       Region 7q16 A 71-78 order
       Region 7q16 A 79-81 disorder
Seq 103-127 Hetero dimer : IID00720Complex
 Evidence NMR 1g5j B Reference
       Region 1g5j B 103-127 order
SeqProS possible 71-78 The corresponding region of mouse Bad (Q61337) is reported to be disordered (PMID: 16645638) . Hetero dimer : IID00061Complex
       Region 7q16 A 71-78 order
SeqProS possible 103-127 The corresponding region of mouse Bad (Q61337) is reported to be disordered (PMID: 16645638) . Hetero dimer : IID00720Complex
       Region 1g5j B 103-127 order
Seqphosphorylation
    99-99 Phosphoserine; by PKB/AKT1
    134-134 Phosphoserine
    118-118 Phosphoserine
    99-99 Phosphoserine; by PKA
    97-97 Phosphoserine
    91-91 Phosphoserine
    75-75 Phosphoserine
    25-25 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-113,129-168
Order 114-128
ProS 1-9,20-32,42-48,90-96,101-113,129-133,144-160
AlphaFold
Disorder 2-2,9-101,124-129,132-145,159-168
Order 1-1,3-8,102-123,130-131,146-158
SEG 21-35
Function
Function in SwissProt
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.