Search Keyword:


Search option:


IID01002
 UniprotQ92968
ProteinPeroxisomal membrane protein PEX13
GenePEX13
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
403
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 261-346 Monomer :
 Evidence X-RAY 7z0i A Reference
       Region 7z0i A 261-263 disorder
       Region 7z0i A 264-341 order
       Region 7z0i A 342-346 disorder
Seq 261-346 Hetero tetramer : IID00944Complex
 Evidence X-RAY 7z0k A Reference
       Region 7z0k A 261-264 disorder
       Region 7z0k A 265-341 order
       Region 7z0k A 342-346 disorder
 Evidence X-RAY 7z0k B Reference
       Region 7z0k B 261-264 disorder
       Region 7z0k B 265-346 order
Seq 261-346,371-383 homo dimer :
 Evidence X-RAY 7z0j A Reference
       Region 7z0j A 261-264 disorder
       Region 7z0j A 265-340 order
       Region 7z0j A 341-346 disorder
       Region 7z0j A 371-382 order
       Region 7z0j A 383-383 disorder
 Evidence X-RAY 7z0j B Reference
       Region 7z0j B 261-263 disorder
       Region 7z0j B 264-345 order
       Region 7z0j B 346-346 disorder
       Region 7z0j B 371-383 disorder
SeqProS verified 371-382 The intramolecular interaction of the PEX13 FxxxF motif regulates binding of PEX5 WxxxF/Y motifs to the PEX13 SH3 domain (PMID: 38632234). homo dimer :
       Region 7z0j A 371-382 order
       Region 7z0j B 371-383 disorder
 
Prediction
NeProc
Disorder 1-127,190-238,337-403
Order 128-189,239-336
ProS 5-16,68-69,73-119,190-202,208-215,233-238,380-390,395-403
AlphaFold
Disorder 1-5,13-50,60-115,177-177,199-232,255-264,341-403
Order 6-12,51-59,116-176,178-198,233-254,265-340
SEG 5-11 ,18-28 ,74-106 ,189-204 ,345-354
Function
Function in SwissProt
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:8858165, PubMed:28765278). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:9653144, PubMed:8858165, PubMed:28765278). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:9653144, PubMed:8858165).