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IID01004
 UniprotQ96BN8
ProteinUbiquitin thioesterase otulin
GeneOTULIN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
352
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 49-67 Hetero tetramer : IID00576Complex
 Evidence X-RAY 4oyk C Reference
       Region 4oyk C 49-52 disorder
       Region 4oyk C 53-65 order
       Region 4oyk C 66-67 disorder
 Evidence X-RAY 4oyk D Reference
       Region 4oyk D 49-52 disorder
       Region 4oyk D 53-67 order
Seq 52-61 Hetero dimer : IID00576Complex
 Evidence X-RAY 4p0b B Reference
       Region 4p0b B 52-53 disorder
       Region 4p0b B 54-57 order
       Region 4p0b B 58-61 disorder
 Evidence X-RAY 4p0b D Reference
       Region 4p0b D 52-53 disorder
       Region 4p0b D 54-57 order
       Region 4p0b D 58-61 disorder
Seq 55-352 Hetero tetramer : P0CG48
 Evidence X-RAY 4ksk A Reference
       Region 4ksk A 55-77 disorder
       Region 4ksk A 78-173 order
       Region 4ksk A 174-182 disorder
       Region 4ksk A 183-346 order
       Region 4ksk A 347-352 disorder
 Evidence X-RAY 4ksk B Reference
       Region 4ksk B 55-77 disorder
       Region 4ksk B 78-173 order
       Region 4ksk B 174-182 disorder
       Region 4ksk B 183-346 order
       Region 4ksk B 347-352 disorder
Seq 79-352 Hetero 24mer : P0CG48
 Evidence X-RAY 4ksl A Reference
       Region 4ksl A 79-173 order
       Region 4ksl A 174-180 disorder
       Region 4ksl A 181-348 order
       Region 4ksl A 349-352 disorder
 Evidence X-RAY 4ksl B Reference
       Region 4ksl B 79-173 order
       Region 4ksl B 174-180 disorder
       Region 4ksl B 181-348 order
       Region 4ksl B 349-352 disorder
 Evidence X-RAY 4ksl E Reference
       Region 4ksl E 79-173 order
       Region 4ksl E 174-181 disorder
       Region 4ksl E 182-348 order
       Region 4ksl E 349-352 disorder
 Evidence X-RAY 4ksl G Reference
       Region 4ksl G 79-173 order
       Region 4ksl G 174-182 disorder
       Region 4ksl G 183-348 order
       Region 4ksl G 349-352 disorder
 Evidence X-RAY 4ksl I Reference
       Region 4ksl I 79-173 order
       Region 4ksl I 174-181 disorder
       Region 4ksl I 182-348 order
       Region 4ksl I 349-352 disorder
 Evidence X-RAY 4ksl K Reference
       Region 4ksl K 79-348 order
       Region 4ksl K 349-352 disorder
 Evidence X-RAY 4ksl M Reference
       Region 4ksl M 79-174 order
       Region 4ksl M 175-184 disorder
       Region 4ksl M 185-348 order
       Region 4ksl M 349-352 disorder
 Evidence X-RAY 4ksl O Reference
       Region 4ksl O 79-348 order
       Region 4ksl O 349-352 disorder
 Evidence X-RAY 4ksl Q Reference
       Region 4ksl Q 79-173 order
       Region 4ksl Q 174-182 disorder
       Region 4ksl Q 183-348 order
       Region 4ksl Q 349-352 disorder
 Evidence X-RAY 4ksl S Reference
       Region 4ksl S 79-174 order
       Region 4ksl S 175-181 disorder
       Region 4ksl S 182-348 order
       Region 4ksl S 349-352 disorder
 Evidence X-RAY 4ksl U Reference
       Region 4ksl U 79-173 order
       Region 4ksl U 174-182 disorder
       Region 4ksl U 183-348 order
       Region 4ksl U 349-352 disorder
 Evidence X-RAY 4ksl W Reference
       Region 4ksl W 79-173 order
       Region 4ksl W 174-183 disorder
       Region 4ksl W 184-348 order
       Region 4ksl W 349-352 disorder
Seq 79-352 Monomer :
 Evidence X-RAY 3znv A Reference
       Region 3znv A 80-346 order
       Region 3znv A 347-352 disorder
 Evidence X-RAY 3znx A Reference
       Region 3znx A 80-174 order
       Region 3znx A 175-182 disorder
       Region 3znx A 183-345 order
       Region 3znx A 346-352 disorder
 Evidence X-RAY 4ksj A Reference
       Region 4ksj A 79-173 order
       Region 4ksj A 174-182 disorder
       Region 4ksj A 183-345 order
       Region 4ksj A 346-352 disorder
 Evidence X-RAY 6i9c A Reference
       Region 6i9c A 80-174 order
       Region 6i9c A 175-182 disorder
       Region 6i9c A 183-345 order
Seq 80-352 Hetero dimer : P0CG48
 Evidence X-RAY 3znz A Reference
       Region 3znz A 80-174 order
       Region 3znz A 175-182 disorder
       Region 3znz A 183-351 order
       Region 3znz A 352-352 disorder
 Evidence X-RAY 5oe7 A Reference
       Region 5oe7 A 80-175 order
       Region 5oe7 A 176-182 disorder
       Region 5oe7 A 183-350 order
Seq 80-352 Hetero tetramer : Q96L92
 Evidence X-RAY 6sak A Reference
       Region 6sak A 80-352 order
 Evidence X-RAY 6sak B Reference
       Region 6sak B 80-173 order
       Region 6sak B 174-182 disorder
       Region 6sak B 183-352 order
SeqProS verified 53-67 PUB interacting motif (PIM) Hetero tetramer : IID00576Complex
       Region 4oyk C 53-65 order
       Region 4oyk D 53-67 order
       Region 4ksk A 55-77 disorder
SeqProS verified 53-67 PUB interacting motif (PIM) Hetero dimer : IID00576Complex
       Region 4p0b B 54-57 order
       Region 4p0b D 54-57 order
       Region 4ksk A 55-77 disorder
SeqProS verified 347-352 PDZ domain-binding motif Class I Hetero tetramer : Q96L92
       Region 6sak A 80-352 order
       Region 6sak B 183-352 order
       Region 3znv A 347-352 disorder
Seqphosphorylation
    56-56 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-78
Order 79-352
ProS 4-14,52-62,68-72
AlphaFold
Disorder 1-78,178-182,348-352
Order 79-177,183-347
SEG 18-37 ,61-70
Function
Function in SwissProt
Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039, PubMed:35170849, PubMed:35587511). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334).