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IID01005
 UniprotQ96DR7
ProteinRho guanine nucleotide exchange factor 26
GeneARHGEF26
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
871
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 42-52 Hetero dimer : Q14160
 Evidence X-RAY 6mye B Reference
       Region 6mye B 42-52 order
Seq 311-322 Hetero tetramer : Q9WVQ1
 Evidence X-RAY 7ykg B Reference
       Region 7ykg B 311-322 order
 Evidence X-RAY 7ykg D Reference
       Region 7ykg D 311-322 order
SeqProS predicted 42-52 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : Q14160
       Region 6mye B 42-52 order
SeqProS predicted 311-322 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : Q9WVQ1
       Region 7ykg B 311-322 order
       Region 7ykg D 311-322 order
Seqphosphorylation
    392-392 Phosphoserine
    22-22 Phosphoserine
 
Prediction
NeProc
Disorder 1-422,668-675,720-740
Order 423-667,676-719,741-778,783-871
ProS 1-26,37-59,82-87,243-256,280-284,304-310,344-349,357-363,369-395,415-422
AlphaFold
Disorder 1-377,383-416,430-431,667-676,718-742,779-787,860-871
Order 378-382,417-429,432-666,677-717,743-778,788-859
Pfam Hmmer
656->782 443-622 793->848
SEG 102-119 ,132-150
Function
Function in SwissProt
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.