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IID01007
 UniprotQ96GN5
ProteinCell division cycle-associated 7-like protein
GeneCDCA7L
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
454
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-32 Hetero dimer : IID00408Complex
 Evidence NMR 6emo A Reference
       Region 6emo A 1-32 order
       Region 6emo A 1-4 high_rmsd
       Region 6emo A 32-32 high_rmsd
Seqdisorder 1-130
 Evidence NMR¸ CD Circular dichroism (CD) spectra obtained for the fragment revealed the absence of regular secondary structure elements. 1D 1H and two-dimensional (2D) 15N/1H HSQC NMR spectra of JPO2 1-130 showed poor dispersion of groups of signals that are usually well-dispersed in structured globular proteins. Reference
       Region 1-130 disorder
Seq 56-91 Hetero dimer : IID00408Complex
 Evidence NMR 5yi9 A Reference
       Region 5yi9 A 56-91 order
       Region 5yi9 A 56-59 high_rmsd
SeqProS verified 5-31 The residues with high_rmsd are excluded from the ProS; IBD (Integrase-binding domain) binding Hetero dimer : IID00408Complex
       Region 6emo A 1-32 order
       Region 1-130 disorder
SeqProS verified 60-91 The residues with high_rmsd are excluded from the ProS; IBD (Integrase-binding domain) binding Hetero dimer : IID00408Complex
       Region 5yi9 A 56-91 order
       Region 1-130 disorder
Seqphosphorylation
    21-21 Phosphoserine
    77-77 Phosphothreonine
    88-88 Phosphothreonine
    79-79 Phosphoserine
    81-81 Phosphothreonine
    261-261 Phosphoserine
    197-197 Phosphoserine
    195-195 Phosphoserine
    162-162 Phosphoserine
    139-139 Phosphoserine
    138-138 Phosphoserine
    117-117 Phosphoserine
    108-108 Phosphoserine
    105-105 Phosphoserine
 
Prediction
NeProc
Disorder 1-13,30-344,449-454
Order 14-29,345-448
ProS 1-13,30-35,43-93,139-149,211-244,294-312,322-344,449-449
AlphaFold
Disorder 1-8,20-62,73-73,75-210,239-270,272-275,277-277,280-288,290-290,293-293,296-322,454-454
Order 9-19,63-72,74-74,211-238,271-271,276-276,278-279,289-289,291-292,294-295,323-453
SEG 118-126 ,131-139 ,191-212
Function
Function in SwissProt
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.