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IID01008
 UniprotQ96NW7
ProteinLeucine-rich repeat-containing protein 7
GeneLRRC7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1537
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 797-818 Hetero dimer : Q9UQM7
 Evidence X-RAY 6x5g B Reference
       Region 6x5g B 797-803 disorder
       Region 6x5g B 804-817 order
       Region 6x5g B 818-818 disorder
Seq 1445-1536 Hetero dimer : IID00700Complex
 Evidence X-RAY 7qqm A Reference
       Region 7qqm A 1445-1536 order
SeqProS predicted 804-817 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : Q9UQM7
       Region 6x5g B 804-817 order
Seqphosphorylation
    439-439 Phosphoserine
    441-441 Phosphoserine
    443-443 Phosphoserine
    831-831 Phosphothreonine
    850-850 Phosphoserine
    865-865 Phosphothreonine
    869-869 Phosphoserine
    947-947 Phosphoserine
    949-949 Phosphoserine
    1118-1118 Phosphoserine
    1439-1439 Phosphoserine
    1335-1335 Phosphoserine
    1233-1233 Phosphoserine
 
Prediction
NeProc
Disorder 1-8,431-958,970-1443
Order 9-430,959-969,1444-1537
ProS 5-8,447-465,474-509,516-521,601-605,614-619,633-665,672-680,685-689,701-706,719-728,735-747,758-782,791-795,807-833,840-898,908-911,923-958,979-982,990-1012,1026-1035,1051-1060,1068-1074,1083-1086,1102-1148,1167-1182,1197-1239,1311-1318,1329-1346,1353-1359,1370-1376,1403-1407
AlphaFold
Disorder 1-22,401-401,431-1268,1271-1271,1279-1443,1455-1455,1467-1469,1536-1537
Order 23-400,402-430,1269-1270,1272-1278,1444-1454,1456-1466,1470-1535
SEG 135-146 ,274-282 ,461-471 ,790-804 ,859-873 ,1456-1469
Function
Function in SwissProt
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.